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键合型手性固定相的研究进展

陈娇 ,  石浩

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引用本文: 陈娇,  石浩. 键合型手性固定相的研究进展[J]. 色谱, 2017, 35(12): 1229-1239. doi: 10.3724/SP.J.1123.2017.09017 shu
Citation:  CHEN Jiao,  SHI Hao. Research progress of bonded chiral stationary phases[J]. Chinese Journal of Chromatography, 2017, 35(12): 1229-1239. doi: 10.3724/SP.J.1123.2017.09017 shu

键合型手性固定相的研究进展

  • 浙江工业大学药学院, 浙江 杭州 310014

  • 基金项目:

    浙江省自然科学基金项目（LY13B020013）.

摘要: 手性分离在生物医药等领域具有重要意义。高效液相色谱（HPLC）因其经济、快速、高效等特点被广泛应用于手性化合物的分离分析中。手性固定相（CSP）是HPLC实现手性分离的核心，而制备有效CSP的关键在于手性选择剂的筛选。近年来，大量文献报道了新型CSPs的制备，其中键合型CSPs因具有溶剂耐受性和较高稳定性等优点受到了广泛关注。该文对近年来以手性单分子、多糖、环糊精、大环抗生素、冠醚、杯芳烃及生物碱等为手性选择剂制备的新型键合型CSPs进行了归纳整理，并对其发展前景进行了展望。

English

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