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Synthesis, antibacterial and anti-inflammatory activity of bis(indolyl)methanes

Santhisudha Sarva ,  Jayaprakash Soora Harinath ,  Siva Prasad Sthanikam ,  Selvarajan Ethiraj ,  Mohanasrinivasan Vaithiyalingam ,  Suresh Reddy Cirandur

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Citation:  Santhisudha Sarva, Jayaprakash Soora Harinath, Siva Prasad Sthanikam, Selvarajan Ethiraj, Mohanasrinivasan Vaithiyalingam, Suresh Reddy Cirandur. Synthesis, antibacterial and anti-inflammatory activity of bis(indolyl)methanes[J]. Chinese Chemical Letters, 2016, 27(01): 16-20. doi: 10.1016/j.cclet.2015.08.012 shu

Synthesis, antibacterial and anti-inflammatory activity of bis(indolyl)methanes

  • 1.

    a Department of Chemistry, Sri Venkateswara University, Tirupati 517 502, India;

  • 2.

    b School of Biosciences and Technology, VIT University, Vellore 632014, India

    • 通讯作者: Suresh Reddy Cirandur,
摘要: A series of bioactive bis(indolyl)methanes are synthesized by one-pot green reaction of indole with various substituted aldehydes by microwave irradiation under solvent free conditions. The antibacterial activity against Staphylococcus aureus and anti-inflammatory activity of the synthesized bis(indolyl)-methanes are evaluated in vitro and compared to standard drugs tetracycline and diclofenac, respectively. The majority of the compounds showed good antibacterial and anti-inflammatory activity. Interestingly, compounds 3j, 3i, 3k and 3g exhibited much higher anti-inflammatory activity than the standard diclofenac drug and thus qualify for clinical trials to be used as an anti-inflammatory compound.

English

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  • 发布日期:  2015-08-24
  • 收稿日期:  2015-01-15
  • 网络出版日期:  2015-05-21
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