引用本文:
刘金, 韦琨, 蔡乐, 曹秋娥, 刘世熙. 苯佐卡因的改进合成——推荐一个环保的多步合成实验[J]. 大学化学,
2016, 31(3): 64-67.
doi:
10.3866/PKU.DXHX20160364
Citation: LIU Jin, WEI Kun, CAI Le, CAO Qiu-E, LIU Shi-Xi. Improved Synthesis of Benzocaine: A Proposal for an Environmentally Friendly Oxidation Method as the Key Step[J]. University Chemistry, 2016, 31(3): 64-67. doi: 10.3866/PKU.DXHX20160364
Citation: LIU Jin, WEI Kun, CAI Le, CAO Qiu-E, LIU Shi-Xi. Improved Synthesis of Benzocaine: A Proposal for an Environmentally Friendly Oxidation Method as the Key Step[J]. University Chemistry, 2016, 31(3): 64-67. doi: 10.3866/PKU.DXHX20160364
苯佐卡因的改进合成——推荐一个环保的多步合成实验
English
Improved Synthesis of Benzocaine: A Proposal for an Environmentally Friendly Oxidation Method as the Key Step
Abstract:
An improved synthesis of benzocaine is described. The synthetic route developed involves trichloroisocyanuric acid and 2, 2, 6, 6-tetramethylpiperidine-1-oxyl (TEMPO) co-oxidation system as the key step. The method could avoid high toxicity, pollution, post-processing difficulties and other unfavorable environmental factors. The reactions were carried out under room temperature for short time with high yield and safe, easy, and environment-friendly operation.
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Key words:
- Green chemistry
- / Benzocaine
- / Oxidation
- / Trichloroisocyanuric acid
- / TEMPO
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