引用本文:
肖如亭, 李乃, 董庆洁, 吴志东, 葛明. 改进的Perkin法催化合成香豆素[J]. 应用化学,
2000, 17(3): 288-291.
Citation: XIAO Ru-Ting, LI Nai-Xuan, DONG Qing-Jie, WU Zhi-Dong, GE Ming. Catalytic Synthesis of Coumarin by Modified Perkin Method[J]. Chinese Journal of Applied Chemistry, 2000, 17(3): 288-291.
Citation: XIAO Ru-Ting, LI Nai-Xuan, DONG Qing-Jie, WU Zhi-Dong, GE Ming. Catalytic Synthesis of Coumarin by Modified Perkin Method[J]. Chinese Journal of Applied Chemistry, 2000, 17(3): 288-291.
改进的Perkin法催化合成香豆素
English
Catalytic Synthesis of Coumarin by Modified Perkin Method
Abstract:
The Perkin method for coumarin synthesis from salicylaldehyde and acetic anhydride has been improved by using calcium acetate as catalyst and polyethylene glycol as activator. The influences of the catalyst, activator, acetic anhydride and thermostatic reaction temperature and time on the yield of coumarin were studied. The yield of coumarin could be reached up to 86.6% with lower consumption of acetic anhydride in case the total molar ratio of acetic anhydride to salicylaldehyde=1.9:1 and the reaction was kept 0.5 h at 212~216℃ when the reaction was close to the end.
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Key words:
- coumarin
- / Perkin synthesis
- / polyethylene glycol
- / calcium acetate
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