Electrochemical Allylic Hydrodefluorination Reaction Using Gaseous Ammonia as Hydrogen Source

Sheng Jie ^a, ,
Wu Na ^a, ,
Liu Xu ^a, ,
Liu Feng ^a, ,
Liu Shuai ^a, ,
Ding Weijie ^a, ,
Liu Chang ^a, ,
Cheng Xu ^{a,b,
,}

a.
Institute of Chemical and Biomedical Science, Jiangsu Advanced Organic Material Laboratory, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023
b.
State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071

Corresponding author: Cheng Xu, chengxu@nju.edu.cn

Received Date: 29 June 2020
Revised Date: 23 July 2020
Available Online: 25 November 2020
Fund Project:

Project supported by the National Natural Science Foundation of China (Nos.22071105, 22031008), the QingLan Project of Jiangsu Education Department and the National Key Research and Development Program of China (No.2019YFC0408303)

Abstract: gem-Difluoroalkenes have wide applications in the drug designs and act as the synthon of molecules containing fluoride. The current researches on the electrochemical syntheses of gem-difluoroalkenes are limited to the silylation of enolated trifluoromethyl ketones. Herein, by using graphite felt as electrodes, the electrochemical allylic hydrodefluorination of α-trifluoromethyl cinnamates is realized using gaseous ammonia as hydrogen source, giving gem-difluorostyrenes in moderate to good yields. The usage of ammonia and graphite felt cathode is important to inhibit the cathodic hydrogen evolution, keeping the electron transfer from cathode to substrate with high selectivity. The cyclic voltammetry (CV) and square wave voltammetry (SWV) analyses support a stepwise electron transfer process to achieve the C—H bond formation and C—F bond cleavage.

Key words:

1. Introduction

gem-Difluoroalkene was an important fluoro synthon in a variety of transformations and applications (Scheme 1, a). For example, α-aminometheneyl gem-difluorostyrene was the inhibitor of monoamine oxidase (MAO)^[1] and pesticide building block.^[2] gem-Difluoroalkenes are reactive substrate in a variety of transformation to build complicated molecules.^[3] For example, Hu et al.^[4] achieved the AgF-mediated fluorinative cross-coupling of gem-difluoroalkenes. Feng and Loh et al.^[5] utilized the gem-difluoroalkenes as starting material in a series of transitionalmetal-catalyzed and photoredox catalysis transformations. The gem-difluorostyrenes were also applied in the thiolation by Dilman group^[6] and fluorohalogenation by Jiang group.^[7] With these divergent applications, the syntheses of gem-difluoroalkenes were extensively studied using a variety of protocols.^[8] For example, by using bromodifluoroacetate as starting material, the gem-difluoroalkene ester was prepared in 4 steps by Matsuda and Kitazume (Scheme 1b).^[9] With the same starting material, the preparation was realized via Julia-Kochienski olefination in 3 steps by the Liu group (Scheme 1b).^[10] König group^[11] reported an photoredox cross-coupling reaction between ketone-derived hydrazone and sodium trifluoromethane-sulfonate catalyzed by Ir complex (Scheme 1b). Xiao et al.^[12] achieved the ZnO-promoted Wittig reaction. There has been one substrate reported by Zhou et al.^[13] as an unexpected reaction in the Ni-catalyzed transfer hydrogenation reaction in which the gem-difluoror styrene 2a was obtained (Scheme 1b). Despite no further investigation, this example suggested a potential allylic-hydrodefluorination protocol to prepare the gem-difluoroalkenes.

Scheme 1

Scheme 1. Applications and syntheses of gem-difluoroalkenes

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Electrochemical synthesis recently emerged as a powerful strategy to prepare molecules with innovative pathways.^[14] The electrochemical dechlorination and debromination reactions have been well-established.^[15] However, the direct cleavage of C—F remains a challenging task due to strong bond energy. For example, activation of the Ar—F requires the synergistic catalysis involving photocatalyst and electrolysis in an oxidation process.^[16] So far, the cathodic reduction of C—F bonds focused on the conversion of trifluoromethyl ketones to silyl gem-difluoroenol ether.^[17] We reasoned that the cathodic reductive hydrodefluorination is hard to achieve due to the choice of hydrogen source. As the C—F activation on cathode requires the high reduction potential, the cathodic hydrogen evolution might be predominant at such conditions. Recently, we^[18] reported the electrochemical hydrogenation reaction using gaseous ammonia as the hydrogen source. With the combination of graphite felt cathode and ammonia, the cathodic hydrogen evolution could be inhibited at -2.0 V (vs. SCE). Herein, we reported the electrochemical allylic hydrodefluorination reaction with gaseous ammonia as hydrogen source.

2. Results and discussion

At onset of the study, compound 1a was used as the model substrate to screen various parameters of the allylic hydrodefluorination reaction (Table 1). With graphite felt as both anode and cathode, using gaseous NH₃ at balloon pressure, the desired transformation took place readily at room temperature in MeCN with ⁿBu₄NBF₄ as supporting electrolyte, giving product 2a in 78% NMR yield and 66% isolated yield (Entry 1). As expected, in the absence either electricity (Entry 2) or gaseous ammonia (Entry 3), no conversion was observed. Other supporting electrolytes instead of ⁿBu₄NBF₄ were evaluated, and the NMR yield were inferior to that obtained in standard conditions (Entries 4~7). When the reaction was carried out in other solvents than MeCN, for example dimethyl sulfoxide (DMSO) and MeOH, the yields dropped dramatically. On the other hand, N, N-dimethylformamide (DMF) gave almost the identical yield to MeCN (Entry 10). Next, the constant current method was applied instead of controlled cell potential, and found constant current at a density of 15 mA/cm³ could offer 66% yield (Entry 11). It was noted as the graphite felt was porous material, the planar surface did not make sense. The volume of graphite felt was used in the expression of current density. Varied cell potentials were examined as well, the yield increased from 49% to 78% when the cell potential moved up from 2.8 to 3.2 V. Further elevation of cell potential resulted in the decrease of yields (Entry 12). This observation was in accord with the results from constant current experiments in Entry 11. Finally, the cathode material was comparaed. By changing the graphite felt to graphite rod or platinum, the reaction was inhibited (Entries 13, 14).

Table 1

Table 1. Reaction optimization of electrochemical hydrodefluorination reaction^a

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Entry	Variation from standard condition	Yield^b/%
1	None	78 (66^c)
2	No voltage	0
3	No NH₃	0
4	LiClO₄ instead of ⁿBu₄NBF₄	62
5	LiBF₄ instead of ⁿBu₄NBF₄	54
6	nBu₄NPF₆ instead of ⁿBu₄NBF₄	67
7	nBu₄NClO₄ instead of ⁿBu₄NBF₄	71
8	DMSO as solvent	48
9	MeOH as solvent	32
10	DMF as solvent	76
11	Constant current is 55, 111, 167, 222 mA/g^d	23, 47, 66, 42
12	Constant voltage is 2.8, 3.0, 3.4, 3.6 V	49, 59, 68, 28
13	Graphite rod instead of graphite felt	14
14	Platinum sheet as cathode graphite felt as anode trace	Trace
^a Standard condition: 1a (0.2 mmol), ⁿBu₄NBF₄ (0.3 equiv.), CH₃CN (5 mL), graphite felt anode and cathode, undivided cell, 3.2 V cell voltage, r.t., NH₃ atmosphere, 5 h. ^b Yields determined by ¹H NMR with dichloromethane as the internal standard. ^c Isolated yield. ^d As graphite felt is the complex of fibre, the mA/g is more suitable to describe the constant current condition.

With the optimal conditions in hand (Table 1, Entry 1), the substrate scope of electrochemical hydrodefluorination reaction was explored (Table 2). The methyl substitution in substrates 1b and 1c unexpectedly sabotaged the reaction yield substantially, due to overdefluorination reaction. It is gratifying to isolate the product 2d with p-methoxy substitution in 89% yield. Electron-withdrawing group, for example, CF₃ group, impact the yield with a 59% yield. The product 2f with para-^tBu group was obtained in moderate yield. It was glad to observe that the vinyl group in product 2g was intact and the corresponding yield was 70%. The good yield of 2h was also realized in 5 h. Next, a series of substrates 1i~1n bearing halogen atom were subject to the standard hydrodefluorination reaction. The yields were around 60%, except the products 2k and 2l containing Cl atom. The low yields of both products were majorly caused by the extensive purification. Especially, the para-bromo atom in product 2m survived the electrochemical process, demonstrating the functional group compatibility of this protocol. Products 2o~2q bearing fused rings were achieved in good yields. Gladly, product 2r containing thiophenyl group could be prepared in 84% isolated yield. Subsequently, the substrates other than ethyl ester were prepared and evaluated. Several esters 1s~1u, bearing n-butyl, t-butyl or allyl group, underwent the transformation readily, and the desired products 2s~2u were generated in yields from 52% to 87%. When trifluoroethyl ester 1v was employed as starting material, the desired product 2v was obtained in only 42% yield partially due to the in situ transamidation reaction. Finally, by using an amide as starting material, product 2w was obtained in good yield (81%).

Table 2

Table 2. Scope of substrates^a

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Next, the electrochemistry analyses were conducted to gain further information of this transformation. The cyclic voltammetry experiments were performed to study the cathodic reduction process (Figure 1, a). At first, the ammonia solution showed totally inert during the whole scan. By deducting the signals of blank sample, the first reduction peak of 1a was observed at -2.0 V (vs. SCE). When the cyclic voltammetry (CV) analysis was carried out under gaseous ammonia, a second weak peak was detected at -2.2 V (vs. SCE). In order to separate these two peaks, square wave voltammetry (SWV) experiment was carried out (Figure 1, b). With the significant separation at a frequency of 10 Hz, a two-step electron transfer was supported.

Figure 1

Figure 1. Electrochemistry analyses of 1a

(a) CV condition: glassy carbon working electrode, Pt wire counter electrode, SCE reference electrode, 50 mV/S. (b) 1a (0.04 mmol), ⁿBu₄BF₄ (0.012 mol/L), MeCN (5 mL), pulse height 25 mV, step height 4 mV, frequency 10 Hz

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With the data achieved, a plausible reaction pathway was proposed in Scheme 2. At first the cathodic electron transfer converts substrate, for example 1a, to its' corresponding radical anion A, in which C(2) was supposed to hold more negative charge because of the carbonyl group. The protonation takes place at this position at first with ammonium cation generated via anodic oxidation of ammonia. A neutral radical B was produced. Consequently, a second anodic electron transfer gives rise to the benzylic anion C that undergoes an elimination to desired product 2a.

Scheme 2

Scheme 2. Plausible reaction pathway of electrochemical defluorinative hydrogenation

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3. Conclusions

In summary, an electrochemical hydrodefluorination reaction with gem-difiluoroalkene esters as products was developed. The catalyst-free reaction employs inexpensive graphite felt as both anode and cathode, ammonia as a safe and environment-friendly hydrogen source. With this protocol, a series of α-trifluoromethyl cinnmates were converted to the gem-difluoro styrenes in moderate to good yields. The CV and SWV analyses supported a two-step electron transfer pathway. Especially, the reaction showed that the combination of ammonia and graphite felt cathode was a highly efficient approach to perform cathodic reduction with substrates requiring high reduction potential.

4. Experimental section

4.1 Instruments and reagents

Column chromatography was generally performed on silica gel (300~400 mesh) and reactions were monitored by thin-layer chromatography (TLC) using 254 nm UV light to visualize the course of the reactions. NMR spectra were recorded on a Bruker Avance 400 MHz spectrometer. High resolution mass spectra were recorded on Agilent G6500 Q-TOF instrument. Electrochemical analyses were carried out on CHI 730E electrochemistry workstation. ¹H NMR (400 MHz), ¹³C NMR (101 MHz) and ¹⁹F (376 MHz) were recorded on Bruker Avance III 400 (400 MHz and 100 MHz). All ¹H NMR and ¹³C NMR spectra are reported in parts per million (ppm) downfield of TMS. High-resolution mass spectra (HRMS) were equipped with an ESI source and a TOF detector mass spectrometer. The melting points were measured with digital melting point detector.

All reactions that required anhydrous conditions were carried by standard procedures under nitrogen atmosphere. Unless otherwise noted, materials (AR grade) were purchased from commercial suppliers, such as J & K, Innochem, and Energy chemicals, and used without further purification. The solvents were dried by distillation over the appropriate drying reagents.

4.2 General procedure of the electrochemical allylic hydrodefluorination reaction

A 10 mL two-necked heart-shaped flask was charged with the substrate 1a (0.2 mmol, 1.0 equiv.), ⁿBu₄NBF₄ (0.06 mmol, 0.3 equiv.) and a magnetic stir bar. The flask was equipped with a rubber stopper. And graphite felt (2 cm×1 cm×0.5 cm) was used as anode and cathode. Two electrodes were separated with a Teflon film. The graphite felt anode was attached to a platinum wire and cathode was attached to a silver wire. A Teflon wire was tied around two electrodes. The flask was evacuated and backfilled with NH₃, and then CH₃CN (5 mL) was added by syringe. The mixture was stirred under room temperature and controlled cell potential electrolysis. After the reaction was completed by monitoring with TLC or GC-MS analysis, the mixture was diluted with water and extracted with EtOAc twice. The combined organic layers were washed with brine, dried over Na₂SO₄, filtered and concentrated. The residue was purified by chromatography on silica gel to afford the desire product 2a. Copounds 2b~2w were synthesized using the same method.

Ethyl 4, 4-difluoro-3-phenylbut-3-enoate (2a): 29 mg, yield 66%, chromatography on silica gel [V(petroleum ether):V(EtOAc)＝98:2], colorless oil. ¹H NMR (400 MHz, Chloroform-d) δ: 7.35 (d, J＝6.1 Hz, 4H), 7.31~7.27 (m, 1H), 4.12 (q, J＝7.1 Hz, 2H), 3.40 (t, J＝2.2 Hz, 2H), 1.20 (t, J＝7.1 Hz, 3H); ¹³C NMR (101 MHz, CDCl₃) δ: 170.20~170.10 (m), 154.79 (dd, J＝292.3, 289.0 Hz), 133.03 (t, J＝3.8 Hz), 128.49, 127.84 (t, J＝3.5 Hz), 87.16 (dd, J＝21.6, 17.9 Hz), 127.53, 61.10, 33.89 (d, J＝2.6 Hz), 14.05; ¹⁹F NMR (376 MHz, Chloroform-d) δ: －86.38 (d, J＝34.8 Hz), －89.22 (d, J＝34.8 Hz); HRMS (ESI) calcd for C₁₂H₁₃F₂O₂ [M+H]⁺ 227.0803, found 227.0873.

Ethyl 4, 4-difluoro-3-(p-tolyl)but-3-enoate (2b): 24 mg, yield 49%, chromatography on silica gel [V(petroleum ether):V(EtOAc)＝98:2], colorless oil. ¹H NMR (400 MHz, Chloroform-d) δ: 7.23 (d, J＝7.9 Hz, 2H), 7.16 (d, J＝8.0 Hz, 2H), 4.12 (q, J＝7.2 Hz, 2H), 3.38 (s, 2H), 2.34 (s, 3H), 1.20 (t, J＝7.1 Hz, 3H); ¹³C NMR (101 MHz, Chloroform-d) δ: 170.19 (dd, J＝4.2, 2.9 Hz), 154.72 (dd, J＝291.8, 288.7 Hz), 137.32, 130.03 (t, J＝3.8 Hz), 129.19, 127.70 (t, J＝3.5 Hz), 87.01 (dd, J＝21.3, 18.0 Hz), 61.03, 33.92 (d, J＝2.6 Hz), 21.09, 14.06; ¹⁹F NMR (376 MHz, Methanol-d₄) δ: －91.09 (d, J＝40.1 Hz), －92.25 (d, J＝39.6 Hz); HRMS (ESI) calcd for C₁₃H₁₅F₂O₂ [M+H]⁺ 241.1040, found 241.1033.

Ethyl 3-(3, 5-dimethylphenyl)-4, 4-difluorobut-3-enoate (2c): 23 mg, yield: 46%, chromatography on silica gel [V(petroleum ether):V(EtOAc)＝98:2], colorless oil. ¹H NMR (400 MHz, Chloroform-d) δ: 6.95 (s, 2H), 6.92 (s, 1H), 4.13 (q, J＝7.1 Hz, 2H), 3.36 (s, 2H), 2.31 (s, 6H), 1.21 (t, J＝7.1 Hz, 3H); ¹³C NMR (101 MHz, Chloroform-d) δ: 170.22 (dd, J＝4.2, 2.9 Hz), 154.77 (dd, J＝291.9, 288.7 Hz), 137.96, 132.91 (t, J＝3.8 Hz), 130.14, 129.27, 126.67, 125.68 (t, J＝3.4 Hz), 87.19 (dd, J＝21.0, 18.1 Hz), 61.01, 34.02 (d, J＝2.7 Hz), 21.30, 14.08; ¹⁹F NMR (376 MHz, Methanol-d₄) δ: －90.46 (d, J＝39.1 Hz), －91.46 (d, J＝39.1 Hz); HRMS (ESI) calcd for C₁₄H₁₇F₂O₂ [M+H]⁺ 255.1196, found 255.1187.

Ethyl 4, 4-difluoro-3-(4-methoxyphenyl)but-3-enoate (2d): 46 mg, yield: 89%, chromatography on silica gel [V(petroleum ether):V(EtOAc)＝98:2], colorless oil. ¹H NMR (400 MHz, Chloroform-d) δ: 7.26 (d, J＝8.6 Hz, 2H), 6.88 (d, J＝8.4 Hz, 2H), 4.12 (q, J＝7.1 Hz, 2H), 3.80 (s, 3H), 3.36 (s, 2H), 1.20 (t, J＝7.1 Hz, 3H); ¹³C NMR (101 MHz, CDCl₃) δ: 170.22 (dd, J＝4.2, 2.9 Hz), 158.89, 154.63 (dd, J＝291.0, 288.5 Hz), 129.05 (t, J＝3.5 Hz), 125.21 (t, J＝3.8 Hz), 113.96, 86.69 (dd, J＝21.6, 18.1 Hz), 61.03, 55.22, 34.03 (d, J＝2.6 Hz), 14.07; ¹⁹F NMR (376 MHz, Methanol-d₄) δ: －91.74 (d, J＝41.5 Hz), －92.87 (d, J＝41.9 Hz); HRMS (ESI) calcd for C₁₃H₁₅F₂O₃ [M+H]⁺ 257.0909, found 257.0981.

Ethyl 4, 4-difluoro-3-(4-(trifluoromethyl)phenyl)but- 3-enoate (2e): 35 mg, yield 59%, chromatography on silica gel [V(petroleum ether):V(EtOAc)＝98:2], colorless oil. ¹H NMR (400 MHz, Chloroform-d) δ: 7.61 (d, J＝8.1 Hz, 2H), 7.47 (d, J＝8.1 Hz, 2H), 4.13 (q, J＝7.1 Hz, 2H), 3.42 (s, 2H), 1.20 (t, J＝6.9 Hz, 3H); ¹³C NMR (101 MHz, Chloroform-d) δ: 169.75 (dd, J＝4.1, 2.7 Hz), 155.13 (dd, J＝294.1, 290.8 Hz), 128.20 (t, J＝3.7 Hz), 125.68 (q, J＝3.7 Hz), 125.46 (q, J＝3.8 Hz), 123.96 (q, J＝272.1 Hz), 86.72 (dd, J＝22.5, 17.1 Hz), 61.29, 33.55 (d, J＝2.5 Hz), 14.01; ¹⁹F NMR (376 MHz, Methanol-d₄) δ: －63.81, －88.29 (d, J＝34.0 Hz), －89.85 (d, J＝34.2 Hz); HRMS (ESI) calcd for C₁₃H₁₂F₅O₂ [M+H]⁺ 295.0757, found 295.0747.

Ethyl 3-(4-(tert-butyl)phenyl)-4, 4-difluorobut-3-enoate (2f): 25 mg, yield 44%, chromatography on silica gel [V(petroleum ether):V(EtOAc)＝98:2], colorless oil. ¹H NMR (400 MHz, Chloroform-d) δ: 7.30 (d, J＝8.6 Hz, 2H), 7.20 (d, J＝8.9 Hz, 2H), 4.06 (q, J＝7.1 Hz, 2H), 3.30 (s, 2H), 1.24 (s, 9H), 1.13 (t, J＝7.1 Hz, 3H); ¹³C NMR (101 MHz, CDCl₃) δ: 170.27 (d, J＝7.0 Hz), 154.83 (dd, J＝292.3, 288.8 Hz), 150.47, 130.02 (t, J＝3.9 Hz), 127.42 (t, J＝3.6 Hz), 125.43, 86.91 (dd, J＝21.3, 17.6 Hz), 61.05, 34.52, 33.88, 33.85, 31.22, 14.06; ¹⁹F NMR (376 MHz, Chloroform-d) δ: －87.15 (d, J＝39.9 Hz), －88.31 (d, J＝40.0 Hz); HRMS (ESI) calcd for C₁₆H₂₁F₂O₂ [M+H]⁺ 283.1509, found 283.1502.

Ethyl 4, 4-difluoro-3-(4-vinylphenyl) but-3-enoate (2g): 36 mg, yield 70%, chromatography on silica gel [V(petroleum ether):V(EtOAc)＝98:2], colorless oil. ¹H NMR (400 MHz, Chloroform-d) δ: 7.40 (d, J＝8.2 Hz, 2H), 7.31 (d, J＝7.8 Hz, 2H), 6.70 (dd, J＝17.6, 10.9 Hz, 1H), 5.76 (d, J＝17.6 Hz, 1H), 5.26 (d, J＝10.8 Hz, 1H), 4.13 (q, J＝7.1 Hz, 2H), 3.39 (s, 2H), 1.21 (t, J＝7.1 Hz, 3H); ¹³C NMR (101 MHz, Chloroform-d) δ: 170.08 (dd, J＝4.1, 2.8 Hz), 154.85 (dd, J＝292.9, 289.4 Hz), 136.19, 132.40 (t, J＝4.0 Hz), 127.92 (t, J＝3.8 Hz), 126.29, 114.26, 87.04 (dd, J＝21.7, 17.5 Hz), 61.09, 33.73 (d, J＝2.8 Hz), 14.09; ¹⁹F NMR (376 MHz, Methanol-d₄) δ: －90.63 (d, J＝38.3 Hz), －91.76 (d, J＝38.5 Hz); HRMS (ESI) calcd for C₁₄H₁₅F₂O₂ [M+H]⁺ 253.1040, found 253.1032.

Ethyl 3-([1, 1'-biphenyl]-4-yl)-4, 4-difluorobut-3-enoate (2h): 49mg, yield 81%, chromatography on silica gel [V(petroleum ether):V(EtOAc)＝95:5], colorless solid. ¹H NMR (400 MHz, Chloroform-d) δ: 7.59 (d, J＝7.8 Hz, 4H), 7.48~7.40 (m, 4H), 7.36 (t, J＝7.4 Hz, 1H), 4.15 (q, J＝7.1 Hz, 2H), 3.44 (s, 2H), 1.22 (t, J＝7.1 Hz, 3H); ¹³C NMR (101 MHz, CDCl₃) δ: 170.20 (d, J＝2.9 Hz), 140.36 (d, J＝11.7 Hz), 132.02~131.87 (m), 128.79, 128.15 (t, J＝3.7 Hz), 127.44, 127.18, 127.00, 86.92 (dd, J＝21.6, 17.3 Hz), 61.16, 33.77 (d, J＝2.5 Hz), 14.08; ¹⁹F NMR (376 MHz, Chloroform-d) δ: －86.06 (d, J＝38.1 Hz), －87.32 (d, J＝37.5 Hz); HRMS (ESI) calcd for C₁₈H₁₇F₂O₂ [M+H]⁺ 303.1196, found 303.1188.

Ethyl 4, 4-difluoro-3-(4-fluorophenyl) but-3-enoate (2i): 30 mg, yield 62%, chromatography on silica gel [V(petroleum ether):V(EtOAc)＝98:2], colorless oil. ¹H NMR (400 MHz, Chloroform-d) δ: 7.33~7.28 (m, 2H), 7.08~7.01 (m, 2H), 4.12 (q, J＝7.1 Hz, 2H), 3.36 (t, J＝2.2 Hz, 2H), 1.20 (t, J＝7.1 Hz, 3H); ¹³C NMR (101 MHz, Chloroform-d) δ: 169.97 (dd, J＝4.1, 2.7 Hz), 162.01 (d, J＝247.5 Hz), 158.06~151.53 (m), 129.69 (dt, J＝7.8, 3.5 Hz), 128.96 (q, J＝3.6 Hz), 115.60, 115.38, 86.48 (dd, J＝22.2, 18.2 Hz), 61.13, 33.98 (d, J＝2.6 Hz), 14.03; ¹⁹F NMR (376 MHz, Methanol-d₄) δ: －90.13 (d, J＝38.6 Hz), －91.39 (d, J＝38.1 Hz), －115.41; HRMS (ESI) calcd for C₁₂H₁₂F₃O₂ [M+H]⁺ 245.0789, found 245.0782.

Ethyl 4, 4-difluoro-3-(3-fluorophenyl) but-3-enoate (2j): 30 mg, yield 62%, chromatography on silica gel [V(petroleum ether):V(EtOAc)＝98:2], colorless oil. ¹H NMR (400 MHz, Chloroform-d) δ: 7.32 (td, J＝8.1, 6.0 Hz, 1H), 7.12 (d, J＝7.8 Hz, 1H), 7.07 (d, J＝8.8 Hz, 1H), 7.03~6.93 (m, 1H), 4.14 (q, J＝7.1 Hz, 2H), 3.38 (t, J＝2.2 Hz, 2H), 1.21 (t, J＝7.1 Hz, 3H); ¹³C NMR (101 MHz, Chloroform-d) δ: 169.86 (dd, J＝4.1, 2.8 Hz), 162.73 (d, J＝245.8 Hz), 154.99 (dd, J＝293.5, 289.9 Hz), 135.18 (dd, J＝8.3, 4.2 Hz), 129.99 (d, J＝8.5 Hz), 123.48 (q, J＝3.2 Hz), 115.10 (dd, J＝4.4, 3.3 Hz), 114.87 (dd, J＝4.4, 3.3 Hz), 114.52 (d, J＝21.0 Hz), 86.98~86.36 (m), 61.22, 33.68 (d, J＝2.6 Hz), 14.05; ¹⁹F NMR (376 MHz, Chloroform-d) δ: －86.59 (d, J＝32.6 Hz), －87.60 (d, J＝32.0 Hz), －112.81; HRMS (ESI) calcd for C₁₂H₁₂F₃O₂ [M+H]⁺ 245.0789, found 245.0792.

Ethyl 3-(4-chlorophenyl)-4, 4-difluorobut-3-enoate (2k): 27 mg, yield 52%, chromatography on silica gel [V(petroleum ether):V(EtOAc)＝98:2], colorless oil. ¹H NMR (400 MHz, Chloroform-d) δ: 7.33 (d, J＝8.6 Hz, 2H), 7.27 (d, J＝8.8 Hz, 2H), 4.12 (q, J＝7.1 Hz, 2H), 3.37 (s, 2H), 1.21 (t, J＝7.1 Hz, 3H); ¹³C NMR (101 MHz, CDCl₃) δ: 169.99~169.86 (m), 154.79 (dd, J＝292.7, 289.9 Hz), 133.45, 131.48 (t, J＝4.0 Hz), 130.25, 129.19 (t, J＝3.7 Hz), 128.94, 128.73, 86.49 (dd, J＝22.1, 17.6 Hz), 61.22, 33.71 (d, J＝2.3 Hz), 14.06; ¹⁹F NMR (376 MHz, Chloroform-d) δ: －87.20 (d, J＝33.8 Hz), －88.36 (d, J＝33.8 Hz); HRMS (ESI) calcd for C₁₂H₁₁ClF₂O₂Na [M+Na]⁺ 283.0314, found 283.0306.

Ethyl 3-(3-chlorophenyl)-4, 4-difluorobut-3-enoate (2l): 21 mg, yield 41%, chromatography on silica gel [V(petroleum ether):V(EtOAc)＝98:2], colorless oil. ¹H NMR (400 MHz, Chloroform-d) δ: 7.26 (s, 1H), 7.23~7.12 (m, 3H), 4.06 (q, J＝7.0 Hz, 2H), 3.30 (s, 2H), 1.14 (t, J＝7.1 Hz, 3H); ¹³C NMR (101 MHz, Chloroform-d) δ: 169.79 (dd, J＝4.2, 2.8 Hz), 154.97 (dd, J＝293.4, 290.1 Hz), 134.90 (t, J＝4.0 Hz), 134.43, 129.72, 128.05 (t, J＝3.8 Hz), 127.74, 126.07 (t, J＝3.5 Hz), 86.55 (dd, J＝22.4, 17.5 Hz), 61.23, 33.68 (d, J＝2.2 Hz), 14.05; ¹⁹F NMR (376 MHz, Chloroform-d) δ: －86.74 (d, J＝32.6 Hz), －87.81 (d, J＝32.5 Hz); HRMS (ESI) calcd for C₁₂H₁₁ClF₂O₂Na [M+Na]⁺ 283.0314, found 283.0310.

Ethyl 3-(4-bromophenyl)-4, 4-difluorobut-3-enoate (2m): 40 mg, yield 66%, chromatography on silica gel [V(petroleum ether):V(EtOAc)＝98:2], colorless oil. ¹H NMR (400 MHz, Chloroform-d) δ: 7.48 (d, J＝8.5 Hz, 2H), 7.21 (d, J＝8.4 Hz, 2H), 4.12 (q, J＝7.1 Hz, 2H), 3.37 (s, 2H), 1.20 (t, J＝7.1 Hz, 3H); ¹³C NMR (101 MHz, Chloroform-d) δ: 169.87 (dd, J＝4.1, 2.8 Hz), 154.74 (dd, J＝292.8, 289.9 Hz), 131.99 (t, J＝4.0 Hz), 131.68, 129.50 (t, J＝3.6 Hz), 121.58, 86.57 (dd, J＝22.2, 17.6 Hz), 61.20, 33.65 (d, J＝2.2 Hz), 14.05; ¹⁹F NMR (376 MHz, Chloroform-d) δ: －87.21 (d, J＝33.7 Hz), －88.38 (d, J＝33.8 Hz); HRMS (ESI) calcd for C₁₂H₁₁BrF₂O₂Na [M+Na]⁺ 326.9808, found 326.9798.

Ethyl 3-(3-bromophenyl)-4, 4-difluorobut-3-enoate (2n): 41 mg, yield 67%, chromatography on silica gel [V(petroleum ether):V(EtOAc)＝98:2], colorless oil. ¹H NMR (400 MHz, Chloroform-d) δ: 7.49 (s, 1H), 7.41 (d, J＝7.6 Hz, 1H), 7.30~7.18 (m, 2H), 4.13 (q, J＝7.1 Hz, 2H), 3.36 (s, 2H), 1.21 (t, J＝7.1 Hz, 3H); ¹³C NMR (101 MHz, Chloroform-d) δ: 169.77 (dd, J＝4.1, 2.8 Hz), 158.44~151.70 (m), 135.18 (t, J＝4.1 Hz), 130.94 (t, J＝3.7 Hz), 130.68, 129.99, 126.57 (t, J＝3.5 Hz), 122.54, 86.48 (dd, J＝22.5, 17.6 Hz), 61.24, 33.70 (d, J＝2.4 Hz), 14.06; ¹⁹F NMR (376 MHz, Methanol-d₄) δ: －90.05 (d, J＝36.8 Hz), －91.16 (d, J＝36.3 Hz); HRMS (ESI) calcd for C₁₂H₁₁BrF₂O₂Na [M+Na]⁺ 326.9808, found 326.9811.

Ethyl 3-(benzofuran-3-yl)-4, 4-difluorobut-3-enoate (2o): 28 mg, yield 78%, chromatography on silica gel [V(petroleum ether):V(EtOAc)＝98:2], colorless oil. ¹H NMR (400 MHz, Chloroform-d) δ: 7.67 (s, 1H), 7.59 (d, J＝7.4 Hz, 1H), 7.50 (d, J＝8.0 Hz, 1H), 7.30 (dt, J＝20.8, 7.1 Hz, 2H), 4.14 (q, J＝7.1 Hz, 2H), 3.42 (s, 2H), 1.20 (t, J＝7.1 Hz, 3H); ¹³C NMR (101 MHz, Chloroform-d) δ: 169.94 (dd, J＝4.1, 2.9 Hz), 154.66 (dd, J＝292.1, 289.8 Hz), 143.32 (dd, J＝5.2, 3.2 Hz), 124.68, 122.93, 120.49 (d, J＝4.6 Hz), 113.69 (dd, J＝4.2, 3.2 Hz), 111.66, 78.63 (dd, J＝26.0, 20.9 Hz), 61.21, 33.88 (d, J＝2.9 Hz), 14.03; ¹⁹F NMR (376 MHz, Chloroform-d) δ: －84.54 (d, J＝32.1 Hz), －88.16 (d, J＝32.6 Hz); HRMS (ESI) calcd for C₁₄H₁₃F₂O₃ [M+H]⁺ 267.0833, found 267.0828.

Ethyl 4, 4-difluoro-3-(phenanthren-9-yl) but-3-enoate (2p): 59 mg, yield 90%, chromatography on silica gel [V(petroleum ether):V(EtOAc)＝98:2], colorless solid. ¹H NMR (400 MHz, Chloroform-d) δ: 8.74 (d, J＝7.8 Hz, 1H), 8.69 (d, J＝8.2 Hz, 1H), 7.98 (d, J＝7.9 Hz, 1H), 7.88 (d, J＝7.3 Hz, 1H), 7.77 (s, 1H), 7.72~7.58 (m, 4H), 4.08 (q, J＝7.1 Hz, 2H), 3.48 (s, 2H), 1.14 (t, J＝7.2 Hz, 3H); ¹³C NMR (101 MHz, Chloroform-d) δ: 170.01~169.74 (m), 157.90~151.90 (m), 131.26, 130.75, 130.36, 130.10, 129.02 (d, J＝3.8 Hz), 128.77, 127.15, 126.87 (d, J＝3.7 Hz), 126.73, 125.45, 123.16, 122.53, 85.07 (t, J＝22.4 Hz), 61.07, 35.19 (d, J＝2.5 Hz), 14.02; ¹⁹F NMR (376 MHz, Chloroform-d) δ: －86.44 (d, J＝34.8 Hz), －89.29 (d, J＝34.8 Hz); HRMS (ESI) calcd for C₂₀H₁₇F₂O₂ [M+H]⁺ 327.1196, found 327.1188.

Ethyl 4, 4-difluoro-3-(naphthalen-1-yl) but-3-enoate (2q): 50 mg, yield 90%, chromatography on silica gel [V(petroleum ether):V(EtOAc)＝98:2], colorless solid. ¹H NMR (400 MHz, Chloroform-d) δ: 7.94 (d, J＝8.1 Hz, 1H), 7.91~7.82 (m, 2H), 7.58~7.50 (m, 2H), 7.48 (d, J＝5.6 Hz, 2H), 4.08 (q, J＝7.1 Hz, 2H), 3.48 (s, 2H), 1.14 (d, J＝14.3 Hz, 3H); ¹³C NMR (101 MHz, Chloroform-d) δ: 171.98~167.34 (m), 154.52 (dd, J＝291.4, 288.2 Hz), 133.77, 131.35 (d, J＝2.5 Hz), 130.45 (dd, J＝4.4, 1.8 Hz), 128.72, 127.70, 128.54, (dd, J＝3.4, 1.5 Hz), 125.96, 126.43, 125.29, 124.76, 88.74~82.49 (m), 61.00, 35.37 (d, J＝2.6 Hz), 13.96; ¹⁹F NMR (376 MHz, Chloroform-d) δ: －86.65 (d, J＝34.9 Hz), －89.59 (d, J＝34.9 Hz); HRMS (ESI) calcd for C₁₆H₁₄F₂O₂Na [M+Na]⁺ 299.0860, found 299.0868.

Ethyl 4, 4-difluoro-3-(thiophen-3-yl) but-3-enoate (2r): 39 mg, yield 84%, chromatography on silica gel [V(petroleum ether):V(EtOAc)＝98:2], colorless oil. ¹H NMR (400 MHz, Chloroform-d) δ: 7.32 (dd, J＝5.2, 3.1 Hz, 1H), 7.23 (s, 1H), 7.18 (d, J＝4.9 Hz, 1H), 4.15 (q, J＝7.1 Hz, 2H), 3.38 (s, 2H), 1.23 (t, J＝7.1 Hz, 3H).¹³C NMR (101 MHz, Chloroform-d) δ: 170.33~170.06 (m), 155.04 (dd, J＝294.1, 288.4 Hz), 133.11 (dd, J＝5.4, 3.4 Hz), 126.55 (dd, J＝7.0, 2.3 Hz), 125.76, 121.91 (t, J＝5.5 Hz), 83.81 (dd, J＝23.5, 17.5 Hz), 61.17, 33.40 (d, J＝3.1 Hz), 14.05; ¹⁹F NMR (376 MHz, Chloroform-d) δ: －85.32 (d, J＝34.0 Hz), －89.32 (d, J＝34.0 Hz); HRMS (ESI) calcd for C₁₀H₁₁F₂O_2S [M+H]⁺ 233.0448, found 233.0449.

Butyl 4, 4-difluoro-3-phenylbut-3-enoate (2s): 44 mg, yield 87%, chromatography on silica gel [V(petroleum ether):V(EtOAc)＝98:2], colorless oil. ¹H NMR (400 MHz, Chloroform-d) δ: 7.35 (d, J＝5.5 Hz, 4H), 7.28 (dt, J＝4.9, 2.5 Hz, 1H), 4.07 (t, J＝6.6 Hz, 2H), 3.40 (t, J＝2.1 Hz, 2H), 1.55 (dt, J＝14.6, 6.7 Hz, 2H), 1.29 (dq, J＝14.6, 7.4 Hz, 2H), 0.89 (t, J＝7.4 Hz, 3H); ¹³C NMR (101 MHz, Chloroform-d) δ: 170.19 (dd, J＝4.1, 2.8 Hz), 154.80 (dd, J＝292.4, 289.0 Hz), 133.04 (t, J＝3.8 Hz), 128.48, 127.90~127.71 (m), 127.51, 87.23 (dd, J＝21.5, 17.7 Hz), 64.97, 33.91, 33.89 (d, J＝2.6 Hz), 30.51, 18.97, 13.58; ¹⁹F NMR (376 MHz, Methanol-d₄) δ: －91.09 (d, J＝40.1 Hz), －92.25 (d, J＝39.5 Hz); HRMS (ESI) calcd for C₁₄H₁₇F₂O₂ [M+H]⁺ 255.1196, found 255.1195.

Tert-butyl 4, 4-difluoro-3-phenylbut-3-enoate (2t): 26 mg, yield 52%, chromatography on silica gel [V(petroleum ether):V(EtOAc)＝98:2], colorless oil. ¹H NMR (400 MHz, Chloroform-d) δ: 7.38~7.28 (m, 4H), 7.34~7.25 (m, 1H), 3.34 (t, J＝2.3 Hz, 2H), 1.39 (s, 9H); ¹³C NMR (101 MHz, Chloroform-d) δ: 169.31 (dd, J＝4.0, 2.8 Hz), 154.71 (dd, J＝292.1, 288.7 Hz), 133.26 (t, J＝3.9 Hz), 128.40, 127.87 (t, J＝3.5 Hz), 127.40, 87.63 (dd, J＝21.6, 17.3 Hz), 81.27, 35.09 (d, J＝2.5 Hz), 27.85; ¹⁹F NMR (376 MHz, Methanol-d₄) δ: －91.07 (d, J＝40.2 Hz), －92.41 (d, J＝39.6 Hz); HRMS (ESI) calcd for C₁₄H₁₇F₂O₂ [M+H]⁺ 255.1196, found 255.1198.

Allyl 4, 4-difluoro-3-phenylbut-3-enoate (2u): 32 mg, yield 68%, chromatography on silica gel [V(petroleum ether):V(EtOAc)＝98:2], colorless oil. ¹H NMR (400 MHz, Chloroform-d) δ: 7.35 (d, J＝5.7 Hz, 4H), 7.30~7.27 (m, 1H), 5.85 (ddt, J＝16.6, 11.0, 5.7 Hz, 1H), 5.29~5.13 (m, 2H), 4.57 (d, J＝5.5 Hz, 2H), 3.44 (s, 2H); ¹³C NMR (101 MHz, Chloroform-d) δ: 169.93~169.66 (m), 154.86 (dd, J＝292.5, 289.3 Hz), 132.95 (t, J＝3.8 Hz), 131.73, 128.52, 127.86 (t, J＝3.5 Hz), 127.59, 118.37, 87.08 (dd, J＝21.4, 18.0 Hz), 65.68, 33.83 (d, J＝2.6 Hz); ¹⁹F NMR (376 MHz, Chloroform-d) δ: －86.44 (d, J＝34.8 Hz), －89.29 (d, J＝34.7 Hz); HRMS (ESI) calcd for C₁₃H₁₃F₂O₂ [M+H]⁺ 239.0883, found 239.0880.

2, 2, 2-Trifluoroethyl 4, 4-difluoro-3-phenylbut-3-enoate (2v): 23 mg, yield 42%, chromatography on silica gel [V(petroleum ether):V(EtOAc)＝98:2], colorless oil. ¹H NMR (400 MHz, Chloroform-d) δ: 7.41~7.27 (m, 5H), 4.45 (q, J＝8.4 Hz, 2H), 3.52 (t, J＝2.1 Hz, 2H); ¹³C NMR (101 MHz, Chloroform-d) δ: 168.65 (dd, J＝4.3, 2.9 Hz), 158.17~151.73 (m), 132.56~132.28 (m), 128.65, 128.10~127.55 (m), 122.70 (q, J＝277.1 Hz), 86.48 (dd, J＝21.2, 18.9 Hz), 60.76 (q, J＝36.9 Hz), 33.35 (d, J＝2.6 Hz); ¹⁹F NMR (376 MHz, Chloroform-d) δ: －70.30, －87.50 (d, J＝34.5 Hz), －88.58 (d, J＝34.6 Hz); HRMS (ESI) calcd for C₁₂H₁₀F₅O₂ [M+H]⁺ 281.0601, found 281.0606.

N-Benzyl-4, 4-difluoro-3-phenylbut-3-enamide (2w): 46 mg, yield 81%, chromatography on silica gel [V(petroleum ether):V(EtOAc)＝98:2], colorless oil. ¹H NMR (400 MHz, Chloroform-d) δ: 7.28 (d, J＝4.4 Hz, 4H), 7.27~7.20 (m, 1H), 7.21~7.13 (m, 3H), 7.01~6.93 (m, 2H), 5.83 (s, 1H), 4.31 (d, J＝5.7 Hz, 2H), 3.31 (t, J＝2.2 Hz, 2H); ¹³C NMR (101 MHz, Chloroform-d) δ: 168.87~168.61 (m), 154.79 (dd, J＝294.5, 289.4 Hz), 132.44 (t, J＝3.8 Hz), 128.74, 128.60, 127.88~127.66 (m), 127.41, 126.18 (d, J＝3.2 Hz), 87.71 (dd, J＝21.1, 15.9 Hz), 43.62, 35.70 (d, J＝1.9 Hz); ¹⁹F NMR (376 MHz, Chloroform-d) δ: －86.70 (d, J＝33.5 Hz), －87.41 (d, J＝33.8 Hz); HRMS (ESI) calcd for C₁₇H₁₆F₂NO [M+H]⁺ 288.1200, found 288.1192.

Supporting Information The preparation and characterization of substrate 1a~1w. ¹H NMR and 1³C NMR spectra for all pure products 2a~2w, the CV and SWV experiments. The Supporting Information is available free of charge via the Internet at http://sioc-journal.cn/.

Dedicated to the 40th anniversary of Chinese Journal of Organic Chemistry.

1. [1]
  (a) McDonald, I. A.; Lacoste, J. M.; Bey, P.; Palfreyman, M. G.; Zreika, M. J. Med. Chem. 1985, 28, 186.
  (b) Sayre, L. M. WO2007005737A2. 2007.
2. [2]
  Okada, H.; Morita, M.; Ueda, T.; Takeo, H.; Kominami, H.; Kiriyama, K.; Nakamoto, K.; Yoshida, Y. WO2004052872A1, 2004.
3. [3]
  Koley, S.; Altman, R. A. Isr. J. Chem. 2020, 60, 313.
4. [4]
  (a) Gao, B.; Zhao, Y.; Ni, C.; Hu, J. Org. Lett. 2014, 16, 102.
  (b) Gao, B.; Zhao, Y.; Hu, J. Angew. Chem., Int. Ed. 2015, 54, 638.
5. [5]
  (a) Tian, P.; Feng, C.; Loh, T.-P. Nat. Commun. 2015, 6, 7472.
  (b) Tian, P.; Wang, C.-Q.; Cai, S.-H.; Song, S.; Ye, L.; Feng, C.; Loh, T.-P. J. Am. Chem. Soc. 2016, 138, 15869.
  (c) Cai, S.-H.; Ye, L.; Wang, D.-X.; Wang, Y.-Q.; Lai, L.-J.; Zhu, C.; Feng, C.; Loh, T.-P. Chem. Commun. 2017, 53, 8731.
  (d) Tang, H.-J.; Lin, L.-Z.; Feng, C.; Loh, T.-P. Angew. Chem., Int. Ed. 2017, 56, 9872.
  (e) Zhu, C.; Song, S.; Zhou, L.; Wang, D.-X.; Feng, C.; Loh, T.-P. Chem. Commun. 2017, 53, 9482.
  (f) Tang, H.-J.; Zhang, Y.-F.; Jiang, Y.-W.; Feng, C. Org. Lett. 2018, 20, 5190.
  (g) Zhou, L.; Zhu, C.; Loh, T.-P.; Feng, C. Chem. Commun. 2018, 54, 5618.
  (h) Liu, H.; Ge, L.; Wang, D.-X.; Chen, N.; Feng, C. Angew. Chem., Int. Ed. 2019, 58, 3918.
  (i) Zhou, L.; Zhu, C.; Bi, P.; Feng, C. Chem. Sci. 2019, 10, 1144.
  (j) Zhu, C.; Zhang, Y.-F.; Liu, Z.-Y.; Zhou, L.; Liu, H.; Feng, C. Chem. Sci. 2019, 10, 6721.
  (k) Cao, Z.-C.; Liu, J.-C.; Chu, Y.-Q.; Zhao, F.-M.; Zhu, Y.-H.; She, Y.-B. Chin. J. Org. Chem. 2019, 39, 2499(in Chinese).
  (曹志成, 刘建超, 褚有群, 赵峰鸣, 朱英红, 佘远斌, 有机化学2019, 39, 2499.)
  (l) Du, H.-W.; Sun, J.; Gao, Q.-S.; Wang, J.-Y.; Wang, H.; Xu, Z.; Zhou, M.-D. Org. Lett. 2020, 22, 1542.
6. [6]
  Zubkov, M. O.; Kosobokov, M. D.; Levin, V. V.; Kokorekin, V. A.; Korlyukov, A. A.; Hu, J.; Dilman, A. D. Chem. Sci. 2020, 11, 737. https://pubs.rsc.org/en/content/articlelanding/2019/sc/c9sc04643g#!divAbstract
7. [7]
  Liu, C.; Zhu, C.; Cai, Y.; Yang, Z.; Zeng, H.; Chen, F.; Jiang, H. Chem.-Eur. J. 2020, 26, 1953.
8. [8]
  Chelucci, G. Chem. Rev. 2012, 112, 1344. https://pubmed.ncbi.nlm.nih.gov/22085400/
9. [9]
  Nihei, T.; Iwai, N.; Matsuda, T.; Kitazume, T. J. Org. Chem. 2005, 70, 5912. https://www.researchgate.net/publication/312260011_Pharmacokineticpharmacodynamic_analysis_of_a_novel_anti-hyperuricemic_compound_derived_from_oxidized_porcine_hemin
10. [10]
  Cao, C.-R.; Ou, S.; Jiang, M.; Liu, J.-T. Tetrahedron Lett. 2017, 58, 482. doi: 10.1002/ejoc.201301021#support-information-section
11. [11]
  Wang, S.; Cheng, B.-Y.; Sršen, M.; König, B. J. Am. Chem. Soc. 2020, 142, 7524.
12. [12]
  于蛟, 林锦鸿, 肖吉昌, 有机化学, 2019, 39, 265. https://www.zhangqiaokeyan.com/academic-journal-cn_chinese-journal-organic-chemistry_thesis/0201271521750.htmlYu, J.; Lin, J.-H.; Xiao, J.-C. Chin. J. Org. Chem. 2019, 39, 265(in Chinese). https://www.zhangqiaokeyan.com/academic-journal-cn_chinese-journal-organic-chemistry_thesis/0201271521750.html
13. [13]
  Guo, S.; Yang, P.; Zhou, J. Chem. Commun. 2015, 51, 12115.
14. [14]
  (a) Chen, J.; Lv, S.; Tian, S. ChemSusChem 2019, 12, 115.
  (b) Gandeepan, P.; Kaplaneris, N.; Santoro, S.; Vaccaro, L.; Ackermann, L. ACS Sustainable Chem. Eng. 2019, 7, 8023.
  (c) Mei, H.; Yin, Z.; Liu, J.; Sun, H.; Han, J. Chin. J. Chem. 2019, 37, 292.
  (d) Meyer, T. H.; Finger, L. H.; Gandeepan, P.; Ackermann, L. Trends Chem. 2019, 1, 63.
  (e) Qiu, Y.; Struwe, J.; Ackermann, L. Synlett 2019, 30, 1164.
  (f) Song, C.; Liu, K.; Dong, X.; Chiang, C.-W.; Lei, A. Synlett 2019, 30, 1149.
  (g) Wang, H.; Gao, X.; Lv, Z.; Abdelilah, T.; Lei, A. Chem. Rev. 2019, 119, 6769.
  (h) Xiong, P.; Xu, H.-C. Acc. Chem. Res. 2019, 52, 3339.
  (i) Ye, Z.; Zhang, F. Chin. J. Chem. 2019, 37, 513.
  (j) Yuan, Y.; Lei, A. Acc. Chem. Res. 2019, 52, 3309.
  (k) Zhang, H.-Y.; Tang, R.-P.; Shi, X.-L.; Jie, L.; Wu, J.-W. Chin. J. Org. Chem. 2019, 39, 1837(in Chinese).
  (张怀远, 唐蓉萍, 石星丽, 颉林, 伍家卫, 有机化学, 2019, 39, 1837.)
  (l) Ackermann, L. Acc. Chem. Res. 2020, 53, 84.
  (m) Jiao, K.-J.; Xing, Y.-K.; Yang, Q.-L.; Qiu, H.; Mei, T.-S. Acc. Chem. Res. 2020, 53, 300.
  (n) Li, M.; Hong, J.; Xiao, W.; Yang, Y.; Qiu, D.; Mo, F. ChemSusChem 2020, 13, 1661.
  (o) Rockl, J. L.; Pollok, D.; Franke, R.; Waldvogel, S. R. Acc. Chem. Res. 2020, 53, 45.
  (p) Wang, P.; Gao, X. L.; Huang, P. F.; Lei, A. W. ChemCatChem 2020, 12, 27.
  (q) Wang, X.-Y.; Xu, X.-T.; Wang, Z.-H.; Fang, P.; Mei. T.-S. Chin. J. Org. Chem. 2020, 40, 3738(in Chinese).
  (王向阳, 徐学涛, 王振华, 方萍, 梅天胜, 有机化学, 2020, 40, 3738.)
15. [15]
  Peters, D. G.; McGuire, C. M.; Pasciak, E. M.; Peverly, A. A.; Strawsine, L. M.; Wagoner, E. R.; Barnes, J. T. Rev. Soc. Quim. Mex. 2017, 58, 287.
16. [16]
  Huang, H.; Lambert, T. H. Angew. Chem., Int. Ed. 2020, 59, 658.
17. [17]
  (a) Uneyama, K.; Kato, T. Tetrahedron Lett. 1998, 39, 587.
  (b) Uneyama, K.; Maeda, K.; Kato, T.; Katagiri, T. Tetrahedron Lett. 1998, 39, 3741.
  (c) Uneyama, K.; Mizutani, G. Chem. Commun. 1999, 613.
  (d) Uneyama, K.; Mizutani, G.; Maeda, K.; Kato, T. J. Org. Chem. 1999, 64, 6717.
18. [18]
  (a) Liu, X.; Liu, R.; Qiu, J.; Cheng, X.; Li, G. Angew. Chem., Int. Ed., 2020, 59, 13962.
  (b) Li, J.; He, L.; Liu, X.; Cheng, X.; Li, G. Angew. Chem., Int. Ed. 2019, 58, 1759.

Scheme 1 Applications and syntheses of gem-difluoroalkenes

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Figure 1 Electrochemistry analyses of 1a

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Scheme 2 Plausible reaction pathway of electrochemical defluorinative hydrogenation

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Table 1. Reaction optimization of electrochemical hydrodefluorination reaction^a


Entry	Variation from standard condition	Yield^b/%
1	None	78 (66^c)
2	No voltage	0
3	No NH₃	0
4	LiClO₄ instead of ⁿBu₄NBF₄	62
5	LiBF₄ instead of ⁿBu₄NBF₄	54
6	nBu₄NPF₆ instead of ⁿBu₄NBF₄	67
7	nBu₄NClO₄ instead of ⁿBu₄NBF₄	71
8	DMSO as solvent	48
9	MeOH as solvent	32
10	DMF as solvent	76
11	Constant current is 55, 111, 167, 222 mA/g^d	23, 47, 66, 42
12	Constant voltage is 2.8, 3.0, 3.4, 3.6 V	49, 59, 68, 28
13	Graphite rod instead of graphite felt	14
14	Platinum sheet as cathode graphite felt as anode trace	Trace
^a Standard condition: 1a (0.2 mmol), ⁿBu₄NBF₄ (0.3 equiv.), CH₃CN (5 mL), graphite felt anode and cathode, undivided cell, 3.2 V cell voltage, r.t., NH₃ atmosphere, 5 h. ^b Yields determined by ¹H NMR with dichloromethane as the internal standard. ^c Isolated yield. ^d As graphite felt is the complex of fibre, the mA/g is more suitable to describe the constant current condition.

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Table 2. Scope of substrates^a

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以氨气为氢源的电化学烯丙位氢化脱氟反应研究

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