聚丙烯酸功能化高效发光的La1-xEuxF3纳米晶合成及细胞成像

引用本文: 陈凡, 王中跃, 张艳艳, 余柯涵, 翁丽星, 韦玮. 聚丙烯酸功能化高效发光的La_1-xEu_xF₃纳米晶合成及细胞成像[J]. 物理化学学报, 2017, 33(7): 1446-1452. doi: 10.3866/PKU.WHXB201704102 shu

Citation: CHEN Fan, WANG Zhong-Yue, ZHANG Yan-Yan, YU Ke-Han, WENG Li-Xing, WEI Wei. Synthesis of Poly(acrylic acid)-Functionalized La_1-xEu_xF₃ Nanocrystals with High Photoluminescence for Cellular Imaging[J]. Acta Physico-Chimica Sinica, 2017, 33(7): 1446-1452. doi: 10.3866/PKU.WHXB201704102 shu

聚丙烯酸功能化高效发光的La_1-xEu_xF₃纳米晶合成及细胞成像

陈凡 ^1, ,
王中跃 ^1, ,
张艳艳 ^1, ,
余柯涵 ^1, ,
翁丽星 ^2, ,
韦玮 ^1,

1.
南京邮电大学光电工程学院, 南京 210023;
2.
南京邮电大学信息材料与纳米研究院, 南京 210023
基金项目:
国家重点基础研究发展计划项目（2012CB933301）和国家自然科学基金项目（51502144）资助

摘要: 采用水热合成一锅法制备了聚丙烯酸功能化单分散的La_1-xEu_xF₃纳米颗粒（La_1-xEu_xF₃@PAA NPs）。利用透射电子显微镜（TEM）、X射线衍射（XRD）、傅里叶变换红外光谱（FTIR）和光致发光光谱（PL）对样品的形貌、结构、组成和荧光性能进行表征。该纳米颗粒平均粒径为（7±3）nm，具有较好的分散性、稳定性与生物相容性。将纳米颗粒与HeLa癌细胞共同孵育，体外成像结果表明材料对HeLa癌细胞显示出低细胞毒性。用水热法制备的La_1-xEu_xF₃@PAA纳米颗粒可以作为光学荧光探针用于细胞成像，在生物医学领域表现出巨大的潜力。

关键词:

English

Synthesis of Poly(acrylic acid)-Functionalized La_1-xEu_xF₃ Nanocrystals with High Photoluminescence for Cellular Imaging

1.
School of Optoelectronic Engineering, Nanjing University of Posts and Telecommunications, Nanjing 210023, P. R. China;
2.
Institute of Advanced Materials, Nanjing University of Posts and Telecommunications, Nanjing 210023, P. R. China
Received Date: 03 January 2017
Revised Date: 03 March 2017
Available Online: 07 April 2017
Fund Project:
The project was supported by the National Basic Research Program of China (2012CB933301) and National Natural Science Foundation of China (51502144).

Abstract: Monodisperse La_1-xEu_xF₃ nanoparticles (NPs) were functionalized by poly(acrylic acid) (PAA) via a one-pot modified hydrothermal method. The morphology, crystal structure, surface groups, and luminescence properties of the as-produced La_1-xEu_xF₃@PAA NPs were characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and photoluminescence (PL) spectroscopy. The produced nanoparticles were (7±3) nm in size, water soluble, and buffer stable, with good photostability and biocompatibility. In vitro imaging revealed the low cytotoxicity of the as-synthesized NPs incubated with HeLa cancer cells. Thus, the colloidal La_1-xEu_xF₃@PAA NPs exhibit great potential for use as optical imaging probes in biological applications.

Key words:

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1.
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聚丙烯酸功能化高效发光的La_1-xEu_xF₃纳米晶合成及细胞成像

English

Synthesis of Poly(acrylic acid)-Functionalized La_1-xEu_xF₃ Nanocrystals with High Photoluminescence for Cellular Imaging

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