引用本文:
绳则翠, 周成, 张龄之, 朱亮亮, 姜波, 陈英文, 祝社民, 沈树宝. 自组装多功能反应器固相合成依非巴特[J]. 应用化学,
2012, 29(3): 275-279.
doi:
10.3724/SP.J.1095.2012.00205
Citation: SHENG Zecui, ZHOU Cheng, ZHANG Lingzhi, ZHU Liangliang, JIANG Bo, CHEN Yingwen, ZHU Shemin, SHEN Shubao. Solid-phase Synthesis of Eptifibatide in a Multifunctional Reactor[J]. Chinese Journal of Applied Chemistry, 2012, 29(3): 275-279. doi: 10.3724/SP.J.1095.2012.00205
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Citation: SHENG Zecui, ZHOU Cheng, ZHANG Lingzhi, ZHU Liangliang, JIANG Bo, CHEN Yingwen, ZHU Shemin, SHEN Shubao. Solid-phase Synthesis of Eptifibatide in a Multifunctional Reactor[J]. Chinese Journal of Applied Chemistry, 2012, 29(3): 275-279. doi: 10.3724/SP.J.1095.2012.00205
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自组装多功能反应器固相合成依非巴特
English
Solid-phase Synthesis of Eptifibatide in a Multifunctional Reactor
Abstract:
A home-made reactor possessing functions including reaction,blending,bubbling,protecting with N2 and filtration was fabricated.The effects of the type of resin,solvent,coupling reagent and reaction time on the yield of cyclic eptifibatide were investigated.The results showed the overall yield was up to 86.6%,using Rink Amide AM resin as solid supporter,HBTU/HOBt/DIEA as the coupling reagent,DMF as the solvent and reaction 2 hours in the reactor.The purity of the product as revealed by HPLC could reach 98%.
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Key words:
- Eptifibatide
- / solid-phase synthesis reactor
- / Fmoc method
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