引用本文:
陈名利, 任劲松. Oxazine750对平行四股螺旋结构的识别与稳定作用[J]. 应用化学,
2010, 27(9): 1061-1064.
doi:
10.3724/SP.J.1095.2010.90853
Citation: CHEN Ming-Li, REN Jin-Song. Parallel G-quadruplex Recognition and Stabilization by Oxazine750[J]. Chinese Journal of Applied Chemistry, 2010, 27(9): 1061-1064. doi: 10.3724/SP.J.1095.2010.90853
Citation: CHEN Ming-Li, REN Jin-Song. Parallel G-quadruplex Recognition and Stabilization by Oxazine750[J]. Chinese Journal of Applied Chemistry, 2010, 27(9): 1061-1064. doi: 10.3724/SP.J.1095.2010.90853
Oxazine750对平行四股螺旋结构的识别与稳定作用
English
Parallel G-quadruplex Recognition and Stabilization by Oxazine750
Abstract:
The bindings of small molecular oxazine 750 to d[TG4T]4,d[G4T4G4]2 and c-myc sequences was characterized by means of circular dichroism,thermal denaturation,and so on. Oxazine 750 was found to bind preferentially and strongly to parallel G-quadruplex. It can effectively stabilize the parallel G-quadruplex and destabilize the antiparallel G-quadruplex. The melting temperature of d[TG4T]4 or c-myc is increased by about 11℃ or 40℃ by oxazine 750,respectively. Under the same condition,oxazine 750 decreased the melting temperature of d[G4T4G4]2 by about 8℃.
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Key words:
- G-quadruplex
- / small molecular
- / competition dialysis
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