2,6-二(2'-咪唑啉-2'-基)吡啶合铬(Ⅲ)的合成及其与DNA的相互作用

引用本文: 张金艳, 肖小明, 蒋艳, 谭年元. 2,6-二(2'-咪唑啉-2'-基)吡啶合铬(Ⅲ)的合成及其与DNA的相互作用[J]. 应用化学, 2010, 27(9): 1032-1037. doi: 10.3724/SP.J.1095.2010.90729 shu

Citation: ZHANG Jin-Yan, XIAO Xiao-Ming, JIANG Yan, TAN Nian-Yuan. Synthesis of Chromium(Ⅲ) Complex of 2,6-Di(2'-imidazoline-2'-yl) Pyridine and Its Interaction with DNA[J]. Chinese Journal of Applied Chemistry, 2010, 27(9): 1032-1037. doi: 10.3724/SP.J.1095.2010.90729 shu

2,6-二(2'-咪唑啉-2'-基)吡啶合铬(Ⅲ)的合成及其与DNA的相互作用

a. 湖南师范大学化学化工学院, 长沙 410081;
b. 湖南工程学院化学化工学院, 湘潭
基金项目:
湖南省教育厅重点课题资助项目(08A045)

摘要: 在微波辐射和无催化剂条件下,由吡啶2,6-二甲酸与乙二胺反应合成了2,6-二(2'-咪唑啉-2'-基)吡啶(L),采用常规加热法合成其配合物[CrL₂][NO₃]₃。用核磁共振、红外光谱、元素分析、热重分析和摩尔电导率测试技术对其进行表征分析。通过紫外吸收光谱和黏度测试,分别考察了配体及配合物与DNA的键合常数及其作用方式。结果表明,配体L以氢键和沟面作用方式与DAN键合,而配合物以氢键和静电作用模式与DNA键合。密度泛函理论(DFT)计算结果较好的解释了L及[CrL₂]³⁺与DNA的相互作用模式。

关键词:

English

Synthesis of Chromium(Ⅲ) Complex of 2,6-Di(2'-imidazoline-2'-yl) Pyridine and Its Interaction with DNA

a. College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081;
b. College of Chemistry and Chemical Engineering, Hunan Institute of Engineering, Xiangtan
Received Date: 06 November 2009
Revised Date: 29 January 2010

Abstract: 2,6-Di(2'-imidazoline-2'-yl) pyridine(L) was synthesized from pyridine 2,6-dicarboxylic acid and ethylenediamine under microwave irradiation without catalyst.Its chromium complex[CrL₂] [NO₃]₃ was synthesized by the conventional method.The complex was characterized by IR spectrometry,elemental analysis,¹H NMR,TG-DSC and molar conductivity.The bindings of these two compounds to DNA were investigated by UV spectrometry and viscosity measurement.It is believed that the ligand may bind to DNA by hydrogen bonding and groove-face binding and the complex bind to DNA by hydrogen bonding and external electrostatic binding.The calculation results from density functional theory (DFT) with hybrid functional B3LYP is good agreement with the experimental phenomena.

Key words:

扫一扫看文章

计量

PDF下载量: 0
文章访问数: 232
HTML全文浏览量: 12

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

2,6-二(2'-咪唑啉-2'-基)吡啶合铬(Ⅲ)的合成及其与DNA的相互作用

English

Synthesis of Chromium(Ⅲ) Complex of 2,6-Di(2'-imidazoline-2'-yl) Pyridine and Its Interaction with DNA

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

计量

通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

2,6-二(2'-咪唑啉-2'-基)吡啶合铬(Ⅲ)的合成及其与DNA的相互作用

English

Synthesis of Chromium(Ⅲ) Complex of 2,6-Di(2'-imidazoline-2'-yl) Pyridine and Its Interaction with DNA

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

计量

文章相关

通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs