引用本文:
祝正辉, 雷泽, 蒋明忠, 木晓云, 付正启, 温晓江, 朱洪友. 黄芩素A环的结构修饰[J]. 应用化学,
2010, 27(9): 1038-1041.
doi:
10.3724/SP.J.1095.2010.90715
Citation: ZHU Zheng-Hui, LEI Ze, JIANG Ming-Zhongd, MU Xiao-Yun, FU Zheng-Qi, WEN Xiao-Jiang, ZHU Hong-You. Structural Modification of the A-ring Baicalein[J]. Chinese Journal of Applied Chemistry, 2010, 27(9): 1038-1041. doi: 10.3724/SP.J.1095.2010.90715
Citation: ZHU Zheng-Hui, LEI Ze, JIANG Ming-Zhongd, MU Xiao-Yun, FU Zheng-Qi, WEN Xiao-Jiang, ZHU Hong-You. Structural Modification of the A-ring Baicalein[J]. Chinese Journal of Applied Chemistry, 2010, 27(9): 1038-1041. doi: 10.3724/SP.J.1095.2010.90715
黄芩素A环的结构修饰
English
Structural Modification of the A-ring Baicalein
Abstract:
Using baicalin,the main active component of a traditional Chinese herb Scutellaria baicalensis, and one of its derivative,6,7-diacetoxylbaicalein,as precursors,a series of C8-substituted and di or tri-O-methylated baicalein derivatives was synthesized in good yields by iodination,nitration,reductive amination and selective methoxylation or hydrolysis of 6,7-diacetoxylbaicalein.The structures of these producrs were characterized.They featured with a broad spectrum of biological activities,notably anti-oxidant.
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Key words:
- baicalin
- / diacetoxylbaicalein
- / selective methoxylation
- / structural modification
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