引用本文:
李云辉, 李海燕, 潘利华, 徐经伟, 常宇, 狄燕清, 刘文宇. 4,4'-二溴-6,6'-二(N,N-二(乙氧基羰甲基)氨甲基)-2,2'-联吡啶的合成与表征[J]. 应用化学,
2010, 27(9): 1008-1011.
doi:
10.3724/SP.J.1095.2010.90713
Citation: LI Yun-Hui, LI Hai-Yan, PAN Li-Hua, XU Jing-Wei, CHANG Yu, DI Yan-Qing, LIU Wen-Yu. Preparation and Characterization of 4,4'-Dibromo-6,6'-bis(N,N-bis(ethoxycarbonylmethyl) amino methyl)-2,2'-bipyridine[J]. Chinese Journal of Applied Chemistry, 2010, 27(9): 1008-1011. doi: 10.3724/SP.J.1095.2010.90713
Citation: LI Yun-Hui, LI Hai-Yan, PAN Li-Hua, XU Jing-Wei, CHANG Yu, DI Yan-Qing, LIU Wen-Yu. Preparation and Characterization of 4,4'-Dibromo-6,6'-bis(N,N-bis(ethoxycarbonylmethyl) amino methyl)-2,2'-bipyridine[J]. Chinese Journal of Applied Chemistry, 2010, 27(9): 1008-1011. doi: 10.3724/SP.J.1095.2010.90713
4,4'-二溴-6,6'-二(N,N-二(乙氧基羰甲基)氨甲基)-2,2'-联吡啶的合成与表征
摘要:
以4,4'-二硝基-6,6'-二甲基-2,2'-联吡啶-N,N'-二氧化物为起始原料,经过三氟乙酸酐酯化、羟甲基化、氢溴酸溴甲基化及亚氨基二乙酸二乙酯氢胺基甲基化合成了4,4'-二溴-6,6'-二(N,N-二(乙氧基羰甲基)氨甲基)-2,2'-联吡啶。通过熔点、红外光谱、核磁共振、高效液相色谱、高分辨质谱测试技术表征了该化合物的结构,为合成时间分辨荧光免疫分析新型双功能螯合剂提供了重要中间体。
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关键词:
- 固相时间分辨荧光免疫分析
- / 螯合剂
- / 中间体
- / 二溴二溴甲基联吡啶
- / 二溴二(N,N-二(乙氧基羰甲基)氨甲基)联吡啶
- / 合成
English
Preparation and Characterization of 4,4'-Dibromo-6,6'-bis(N,N-bis(ethoxycarbonylmethyl) amino methyl)-2,2'-bipyridine
Abstract:
4,4'-Dibromo-6,6'-bis (N,N-bis (ethoxycarbonylmethyl) amino methyl)-2,2'-bipyridine was prepared from 4,4'-dinitro-6,6'-dimethyl-2,2'-bipyridine N,N-dioxide by esterification with trifluoroacetic anhydride and hydroxymethylation,bromine methylation with HBr,and methylation of amino hydrogen with diethyl iminodiacetate.The structure of this product was determined by DSC,IR,1H NMR,HPLC and HRMS.The obtained product is an important intermediate for the synthesis of a bi-functional chelate,which could find applications in solid phase time resolved fluoroimmunoassay.
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