引用本文:
陶李明, 刘文奇, 谭倪, 周芸. 5-甲基-2,3-二苯基-1,5-苯并硫氮杂卓-4(5H)-酮的合成[J]. 应用化学,
2010, 27(4): 494-496.
doi:
10.3724/SP.J.1095.2010.90420
Citation: TAO Li-Minga, LIU Wen-Qia, TAN Nib, ZHOU Yun. Synthesis of 5-Methyl-2,3-diphenyl-1,5-benzothiazepin-4(5H)-one[J]. Chinese Journal of Applied Chemistry, 2010, 27(4): 494-496. doi: 10.3724/SP.J.1095.2010.90420
Citation: TAO Li-Minga, LIU Wen-Qia, TAN Nib, ZHOU Yun. Synthesis of 5-Methyl-2,3-diphenyl-1,5-benzothiazepin-4(5H)-one[J]. Chinese Journal of Applied Chemistry, 2010, 27(4): 494-496. doi: 10.3724/SP.J.1095.2010.90420
5-甲基-2,3-二苯基-1,5-苯并硫氮杂卓-4(5H)-酮的合成
摘要:
以2-甲硫基苯胺为原料,通过酰化、碘环化以及Suzuki交叉偶联反应,合成了5-甲基-2,3-二苯基-1,5-苯并硫氮杂卓-4(5H)-酮。分别考察了催化剂对酰化反应、溶剂对碘环化反应的影响,以及催化剂、配体、碱和温度等因素对Suzuki交叉偶联反应的影响,在最佳的反应条件下,反应总收率为68.5%,中间产物和目标产物的结构经IR、NMR和MS等测试技术得以确证。
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关键词:
- 甲基二苯基苯并硫氮杂卓-4(5H)-酮
- / 酰化反应
- / 碘环化反应
- / Suzuki交叉偶联反应
English
Synthesis of 5-Methyl-2,3-diphenyl-1,5-benzothiazepin-4(5H)-one
Abstract:
5-Methyl-2,3-diphenyl-1,5-benzothiazepin-4(5H)-one was synthesized via the acylation reaction and iodocyclization reaction and Suzuki cross-coupling reaction with 2-(methylthio)aniline as the initial material.Effects including catalysts on acylation reaction,solvents on iodocyclization and catalysts,ligand,base and reaction temperature on Suzuki cross-coupling reaction have been investigated.Under optimum conditions,the yield of the product was up to 68.5%.The chemical structures of the intermediates and target product were characterized by IR,NMR and MS spectra.
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