快速自成胶的可注射粘性热敏水凝胶的抗菌和促进伤口愈合性能分析

黄童黛 曹玉玉 江云静 翟贝贝 白荣先 吴杰 尤祥宇 孙红梅

引用本文: 黄童黛, 曹玉玉, 江云静, 翟贝贝, 白荣先, 吴杰, 尤祥宇, 孙红梅. 快速自成胶的可注射粘性热敏水凝胶的抗菌和促进伤口愈合性能分析[J]. 分析化学, 2023, 51(6): 982-993. doi: 10.19756/j.issn.0253-3820.231142 shu
Citation:  HUANG Tong-Dai,  CAO Yu-Yu,  JIANG Yun-Jing,  ZHAI Bei-Bei,  BAI Rong-Xian,  WU Jie,  YOU Xiang-Yu,  SUN Hong-Mei. Analysis of Antimicrobial and Wound-Healing Properties of Injectable and Adhesive Thermosensitive Hydrogels with Ultrafast Self-gelling[J]. Chinese Journal of Analytical Chemistry, 2023, 51(6): 982-993. doi: 10.19756/j.issn.0253-3820.231142 shu

快速自成胶的可注射粘性热敏水凝胶的抗菌和促进伤口愈合性能分析

    通讯作者: 孙红梅,E-mail:hmsunqi@163.com
  • 基金项目:

    湖北工业大学国家“111”细胞调控与分子药学中心合作项目(No.XBTK-2022007)和湖北省教育厅科研计划项目(No.B2017047)资助。

摘要: 开发具有形状适应性和良好抑菌活性的智能水凝胶对于细菌感染创面的治疗非常重要。本研究以生物相容性良好的壳聚糖(CS)、β-甘油磷酸钠(β-GP)和聚多巴胺纳米颗粒(PDA NPs)为原料,制备了具有粘附性和光热抗菌活性的可注射热敏水凝胶。通过在CS上接枝具有贻贝类活性的邻苯二酚基团,提高了水凝胶与组织的粘附性。在生理温度(37℃)下,邻苯二酚改性壳聚糖(CHI-C)、β-GP和PDA NPs经过简单搅拌混匀后,放置1.5 min即可通过氢键和席夫碱键结合形成交联网络。在水凝胶中引入具有高效光热转换能力的PDA NPs不仅赋予水凝胶优异的光热抗菌能力,而且增强了水凝胶网络的力学性能。本研究制备的CHI-C/β-GP/PDA水凝胶具有良好的生物相容性、优异的光热转化能力和极佳的抗菌效果。此水凝胶可在小鼠创面原位形成,这为不规则伤口愈合提供了良好的环境。实验结果表明,制备的智能水凝胶有望成为一种具有良好应用前景的伤口敷料,用于促进细菌感染伤口的愈合。

English


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  • 收稿日期:  2023-04-12
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