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循环肿瘤DNA检测研究新进展

陈欢 ,  韩鑫涛 ,  魏佳 ,  刘嘉男 ,  王国庆 ,  刘万建 ,  田永帅 ,  孟宪瑛 ,  王振新

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引用本文: 陈欢, 韩鑫涛, 魏佳, 刘嘉男, 王国庆, 刘万建, 田永帅, 孟宪瑛, 王振新. 循环肿瘤DNA检测研究新进展[J]. 分析化学, 2021, 49(6): 893-906. doi: 10.19756/j.issn.0253-3820.211106 shu
Citation:  CHEN Huan,  HAN Xin-Tao,  WEI Jia,  LIU Jia-Nan,  WANG Guo-Qing,  LIU Wan-Jian,  TIAN Yong-Shuai,  MENG Xian-Ying,  WANG Zhen-Xin. Recent Progress of Detection of Circulating Tumor DNA[J]. Chinese Journal of Analytical Chemistry, 2021, 49(6): 893-906. doi: 10.19756/j.issn.0253-3820.211106 shu

循环肿瘤DNA检测研究新进展

  • 1.

    青岛汉唐生物科技有限公司, 青岛 266000;

  • 2.

    中国科学院长春应用化学研究所电分析化学国家重点实验室, 长春 130022;

  • 3.

    吉林大学白求恩第一临床医院甲状腺外科, 长春 130021

    • 通讯作者: 田永帅,E-mail:tian_yongshuai@163.com; 孟宪瑛,E-mail:mengxiany@jlu.edu.cn; 王振新,E-mail:wangzx@ciac.ac.cn
  • 基金项目:

    吉林省自然科学基金（学科布局项目）（No.20200201357JC）和山东省泰山产业领军人才工程项目（No.2019TSCYCX-24）资助。

摘要: 循环肿瘤DNA （Circulating tumor DNA，ctDNA）是源自于肿瘤的一种无细胞DNA （Cell free DNA，cfDNA），可能携带与原发肿瘤相同的致癌突变和基因改变。因此，ctDNA有望作为癌症的无创监测生物标志物。研发ctDNA分析新方法可促进用于癌症诊断、预后评估、疗效监测和遗传/表观遗传异常研究的液体活检技术的发展。在过去的几十年中，基于聚合酶链反应（Polymerase chain reaction，PCR）、二代测序（Next-generation sequencing，NGS）等传统的DNA检测技术已被广泛应用于临床样本中ctDNA检测。近来，研究者针对传统DNA检测技术灵敏度较低的问题，研发了多种高性能ctDNA生物传感器用于分析癌症患者血液样本中的ctDNA，为其高灵敏检测提供了新的技术手段。本文综述了ctDNA的分析方法，尤其是近五年来ctDNA生物传感器研究的新进展，探讨了其进入实际临床应用需要解决的技术挑战，为研发癌症液体活检新方法提供了参考。

English


    1. [1]

      WILD C P, WEIDERPASS E, STEWART B W. World Cancer Report: Cancer Research for Cancer Prevention[EB/OL]. Lyon, France, 2020: International Agency for Research on Cancer, 2020: 586.

    2. [2]

      National Cancer Institute Online, https://www.cancer.gov/about-cancer/screening/screening-tests.

    3. [3]

      THOMPSON I M, PAULER D K, GOODMAN P J, TANGEN C M, LUCIA M S, PARNES H L, MINASIAN L M, FORD L G, LIPPMAN S M, CRAWFORD E D, CROWLEY J J, COLTMAN C A. N. Engl. J. Med., 2004, 350(22): 2239-2246.

    4. [4]

      LIOTTA L A, FERRARI M, PETRICOIN E. Nature, 2003, 425(6961): 905.

    5. [5]

      PETRICOIN E F, BELLUCO C, ARAUJO R P, LIOTTA L A. Nat. Rev. Cancer, 2006, 6(12): 961-967.

    6. [6]

      NILSSON J, SKOG J, NORDSTRAND A, BARANOV V, MINCHEVA-NILSSON L, BREAKEFIELD X O, WIDMARK A. Br. J. Cancer, 2009, 100(10): 1603-1607.

    7. [7]

      PRENSNER J R, RUBIN M A, WEI J T, CHINNAIYAN A M. Sci. Transl. Med., 2012, 4(127): 127rv3.

    8. [8]

      CORCORAN R B, CHABNER B A. N. Engl. J. Med., 2018, 379(18): 1754-1765.

    9. [9]

      JONES A, DHANAPALA L, KANKANAMAGE R N T, KUMAR C V, RUSLING J F. Anal. Chem., 2020, 92(1): 345-362.

    10. [10]

      FARES J, FARES M Y, KHACHFE H H, SALHAB H A, FARES Y. Signal Transduction Targeted Ther., 2020, 5(1): 28.

    11. [11]

      LEON S A, SHAPIRO B, SKLAROFF D M, YAROS M J. Cancer Res., 1977, 37(3): 646-650.

    12. [12]

      SORENSON G D, PRIBISH D M, VALONE F H, MEMOLI V A, BZIK D J, YAO S L. Cancer Epidemiol. Biomarkers Prev., 1994, 3(1): 67-71.

    13. [13]

      WU X L, LI J H, GASSA A, BUCHNER D, ALAKUS H, DONG Q Z, REN N, LIU M, ODENTHAL M, STIPPEL D, BRUNS C, ZHAO Y, WAHBA R. Int. J. Biol. Sci., 2020, 16(9): 1551-1562.

    14. [14]

      SNYDER M W, KIRCHER M, HILL A J, DAZA R M, SHENDURE J. Cell, 2016, 164(1-2): 57-68.

    15. [15]

      WAN J C M, MASSIE C, GARCIA-CORBACHO J, MOULIERE F, BRENTON J D, CALDAS C, PACEY S, BAIRD R, ROSENFELD N. Nat. Rev. Cancer., 2017, 17(4): 223-238.

    16. [16]

      KELLER L, BELLOUM Y, WIKMAN H, PANTEL K. Br. J. Cancer, 2021, 124(2): 345-358.

    17. [17]

      WAN J C M, HEIDER K, GALE D, MURPHY S, FISHER E, MOULIERE F, RUIZ-VALDEPENAS A, SANTONJA A, MORRIS J, CHANDRANANDA D, MARSHALL A, GILL A B, CHAN P Y, BARKER E, YOUNG G, COOPER W N, HUDECOVA I, MARASS F, MAIR R, BRINDLE K M, STEWART G D, ABRAHAM J E, CALDAS C, RASSL D M, RINTOUL R C, ALIFRANGIS C, MIDDLETON M R, GALLAGHER F A, PARKINSON C, DURRANI A, MCDERMOTT U, SMITH C G, MASSIE C, CORRIE P G, ROSENFELD N. Sci. Transl. Med., 2020, 12(548): eaaz8084.

    18. [18]

      SCHWAEDERLE M C, PATEL S P, HUSAIN H, IKEDA M, LANMAN R B, BANKS K C, TALASAZ A, BAZHENOVA L, KURZROCK R. Clin. Cancer Res., 2017, 23(17): 5101-5111.

    19. [19]

      SNYDER A, MORRISSEY M P, HELLMANN M D. Clin. Cancer Res., 2019, 25(23): 6909-6915.

    20. [20]

      COHEN J D, JAVED A A, THOBURN C, WONG F, TIE J, GIBBS P, SCHMIDT C M, YIP-SCHNEIDER M T, ALLEN P J, SCHATTNER M, BRAND R E, SINGHI A D, PETERSEN G M, HONG S M, KIM S C, FALCONI M, DOGLIONI C, WEISS M J, AHUJA N, HE J, MAKARY M A, MAITRA A, HANASH S M, DAL MOLIN M, WANG Y, LI L, PTAK J, DOBBYN L, SCHAEFER J, SILLIMAN N, POPOLI M, GOGGINS M G, HRUBAN R H, WOLFGANG C L, KLEIN A P, TOMASETTI C, PAPADOPOULOS N, KINZLER K W, VOGELSTEIN B, LENNON A M. Proc. Natl. Acad. Sci. U. S. A., 2017, 114(38): 10202-10207.

    21. [21]

      WU T H, HSIUE E H, YANG J C. Cancer Treat. Rev., 2019, 78: 31-41.

    22. [22]

      LEARY R J, KINDE I, DIEHL F, SCHMIDT K, CLOUSER C, DUNCAN C, ANTIPOVA A, LEE C, MCKERNAN K, DE LA VEGA F M, KINZLER K W, VOGELSTEIN B, DIAZ L A, JR., VELCULESCU V E. Sci. Transl. Med., 2010, 2(20): 20ra14.

    23. [23]

      XU T, KANG X, YOU X, DAI L, TIAN D, YAN W, YANG Y, XIONG H, LIANG Z, ZHAO G Q, LIN S, CHEN K N, XU G. Theranostics, 2017, 7(6): 1437-1446.

    24. [24]

      ARAVANIS A M, LEE M, KLAUSNER R D. Cell, 2017, 168(4): 571-574.

    25. [25]

      PISAPIA P, MALAPELLE U, TRONCONE G. Acta Cytol., 2019, 63(6): 489-496.

    26. [26]

      ZOU Z, QI P, QING Z H, ZHENG J, YANG S, CHEN W J, YANG R H. Anal. Chem., 2017, 97: 36-49.

    27. [27]

      GORGANNEZHAD L, UMER M, ISLAM M N, NGUYEN N T, SHIDDIKY M J A. Lab Chip, 2018, 18(8): 1174-1196.

    28. [28]

      LI X, YE M, ZHANG W, TAN D, JAFFREZIC-RENAULT N, YANG X, GUO Z. Biosens. Bioelectron., 2019, 126: 596-607.

    29. [29]

      VAIDYANATHAN R, SOON R H, ZHANG P, JIANG K, LIM C T. Lab Chip, 2019, 19(1): 11-34.

    30. [30]

      SODA N, REHM B H A, SONAR P, NGUYEN N T, SHIDDIKY M J A. J. Mater. Chem. B, 2019, 7(43): 6670-6704.

    31. [31]

      PALLARES R M, THANH N T K, SU X D. Nanoscale, 2019, 11(46): 22152-22171.

    32. [32]

      CHEN X M, WANG L, LOU J T. Med. Sci. Monit., 2020, 26:e921040.

    33. [33]

      WEI J, ZHAO Z, GAO J X, WANG Y Q, MA L N, MENG X Y, WANG Z X. ACS Omega, 2020, 5(10): 5365-5371.

    34. [34]

      GUTTERY D S, PAGE K, HILLS A, WOODLEY L, MARCHESE S D, RGHEBI B, HASTINGS R K, LUO J L, PRINGLE J H, STEBBING J, COOMBES R C, ALI S, SHAW J A. Clin. Chem., 2015, 61(7): 974-982.

    35. [35]

      PAGE K, GUTTERY D S, FERNANDEZ-GARCIA D, HILLS A, HASTINGS R K, LUO J L, GODDARD K, SHAHIN V, WOODLEY-BARKER L, ROSALES B M, COOMBES R C, STEBBING J, SHAW J A. Clin. Chem., 2017, 63(2): 532-541.

    36. [36]

      HAHN A W, GILL D M, MAUGHAN B, AGARWAL A, ARJYAL L, GUPTA S, STREETER J, BAILEY E, PAL S K, AGARWAL N. Oncotarget, 2017, 8(20): 33614-33620.

    37. [37]

      GAO M L, CALLARI M, BEDDOWES E, SAMMUT S J, GRZELAK M, BIGGS H, JONES L, BOUMERTIT A, LINN S C, CORTES J, OLIVEIRA M, BAIRD R, CHIN S F, CALDAS C. Genome Med., 2019, 11: 1.

    38. [38]

      WANG B L, WU S C, HUANG F, SHEN M N, JIANG H Q, YU Y Y, YU Q, YANG Y H, ZHAO Y, ZHOU Y W, PAN B S, LIU T S, GUO W. Clin. Chem. Lab. Med., 2019, 57(10): 1501-1510.

    39. [39]

      WANG Y, TIAN P W, WANG W Y, WANG K, ZHANG Z, CHEN B J, HE Y Q, LI L, LIU H, CHUAI S N, LI W M. Oncotarget, 2016, 7(40): 65208-65217.

    40. [40]

      JANKU F, ZHANG S, WATERS J, LIU L, HUANG H J, SUBBIAH V, HONG D S, KARP D D, FU S Q, CAI X Y, RAMZANALI N M, MADWANI K, CABRILO G, ANDREWS D L, ZHAO Y, JAVLE M, KOPETZ E S, LUTHRA R, KIM H J, GNERRE S, SATYA R V, CHUANG H Y, KRUGLYAK K M, TOUNG J, ZHAO C, SHEN R, HEYMACH J V, MERIC-BERNSTAM F, MILLS G B, FAN J B, SALATHIA N S. Clin. Cancer Res., 2017, 23(18): 5648-5656.

    41. [41]

      SUN P, CHEN C, XIA Y, WANG Y, LIU P P, BI X W, SHAO Y W, OU Q X, WU X, YANG H, NIE M, ZHANG X W, LI Z M, JIANG W Q. J. Cancer, 2019, 10(2): 323-331.

    42. [42]

      LIN K K, HARRELL M I, OZA A M, OAKNIN A, RAY-COQUARD I, TINKER A V, HELMAN E, RADKE M R, SAY C, VO L T, MANN E, ISAACSON J D, MALONEY L, O'MALLEY D M, CHAMBERS S K, KAUFMANN S H, SCOTT C L, KONECNY G E, COLEMAN R L, SUN J X, GIORDANO H, BRENTON J D, HARDING T C, MCNEISH I A, SWISHER E M. Cancer Discovery, 2019, 9(2): 210-219.

    43. [43]

      YANG S R, MOONEY K L, LIBIRAN P, JONES C D, JOSHI R, LAU H D, STEHR H, BERRY G J, ZEHNDER J L, LONG S R, KONG C S, KUNDER C A. Cancer Cytopathol., 2020, 128(1): 43-56.

    44. [44]

      WANG J Y, HSIEH J S, CHANG M Y, HUANG T J, CHEN F M, CHENG T L, ALEXANDERSEN K, HUANG Y S, TZOU W S, LIN S R. World J. Surg., 2004, 28(7): 721-726.

    45. [45]

      NAKAMURA T, SUEOKA-ARAGANE N, IWANAGA K, SATO A, KOMIYA K, KOBAYASHI N, HAYASHI S, HOSOMI T, HIRAI M, SUEOKA E, KIMURA S. J. Thorac. Oncol., 2012, 7(9): 1369-1381.

    46. [46]

      ULIVI P, MERCATALI L, CASONI G L, SCARPI E, BUCCHI L, SILVESTRINI R, SANNA S, MONTEVERDE M, AMADORI D, POLETTI V, ZOLI W. PLoS One, 2013, 8(2): e57401.

    47. [47]

      ZHAO X, HAN R B, ZHAO J, WANG J, YANG F, ZHONG W, ZHANG L, LI L Y, WANG M Z. Respiration, 2013, 85(2): 119-125.

    48. [48]

      STADLER J, EDER J, PRATSCHER B, BRANDT S, SCHNELLER D, MULLEGGER R, VOGL C, TRAUTINGER F, BREM G, BURGSTALLER J P. PLoS One, 2015, 10(11): e0142273.

    49. [49]

      FREIDIN M B, FREYDINA D V, LEUNG M, MONTERO FERNANDEZ A, NICHOLSON A G, LIM E. Clin. Chem., 2015, 61(10): 1299-1304.

    50. [50]

      NIE K, JIA Y, ZHANG X. Tumour Biol., 2015, 36(1): 7-19.

    51. [51]

      WANG X,GAO Y, WANG B, ZHANG Z, LIANG C, FENG H, GUO Y, DA J, MO M, ZHANG M, DING F, CHEN Z, LI H, LIU D. Arch. Pathol. Lab. Med., 2017, 141(7): 978-984.

    52. [52]

      XIANG Z, WAN R, ZOU B, QI X, HUANG Q, KUMAR S, PITMAN J L, ZHOU G, SONG Q. Anal. Bioanal. Chem., 2018, 410(26): 6751-6759.

    53. [53]

      EMAUS M N, VARONA M, ANDERSON J L. Anal. Chim. Acta, 2019, 1068: 1-10.

    54. [54]

      ZHANG S, CHEN Z, HUANG C, DING C, LI C, CHEN J, ZHAO J, MIAO L. Analyst, 2019, 144(5): 1718-1724.

    55. [55]

      CAMPOS C D M, GAMAGE S S T, JACKSON J M, WITEK M A, PARK D S, MURPHY M C, GODWIN A K, SOPER S A. Lab Chip, 2018, 18(22): 3459-3470.

    56. [56]

      CHEN N, ZHANG W, TANG X, MING Z, XIAO X. Analyst, 2020, 145(4): 1355-1361.

    57. [57]

      TANG Y, ZOU B, WANG R, LUO N, QI X, ZHOU G, SONG Q. Anal. Methods, 2020, 12(26): 3344-3350.

    58. [58]

      BOTEZATU I V, KONDRATOVA V N, SHELEPOV V P, MAZURENKO N N, TSYGANOVA I V, SUSOVA O Y, LICHTENSTEIN A V. Anal. Biochem., 2020, 590: 113517.

    59. [59]

      PINHEIRO L B, COLEMAN V A, HINDSON C M, HERRMANN J, HINDSON B J, BHAT S, EMSLIE K R. Anal. Chem., 2012, 84(2): 1003-1011.

    60. [60]

      HUGGETT J F, WHALE A. Clin. Chem., 2013, 59(12): 1691-1693.

    61. [61]

      DE MELO-SILVA A J, LUCENA J P, HUENEBURG T. Cell. Biol. Int., 2020, 44(3): 735-743.

    62. [62]

      BRYCHTA N, KRAHN T, VON AHSEN O. Clin. Chem., 2016, 62(11): 1482-1491.

    63. [63]

      JACKSON J B, CHOI D S, LUKETICH J D, PENNATHUR A, STAHLBERG A, GODFREY T E. J. Mol. Diagn., 2016, 18(2): 235-243.

    64. [64]

      YANG K, LI J, ZHAO J, REN P, WANG Z, WEI B, DONG B, SUN R, WANG X, GROEN H J M, MA J, GUO Y. Anal. Chem., 2018, 90(19): 11203-11209.

    65. [65]

      CABEL L, DECRAENE C, BIECHE I, PIERGA J Y, BENNAMOUN M, FUKS D, FERRAZ J M, LEFEVRE M, BAULANDE S, BERNARD V, VACHER S, MARIANI P, PROUDHON C, BIDARD F C, LOUVET C. Cancers, 2019, 11(3): 396.

    66. [66]

      PRATT E D, COWAN R W, MANNING S L, QIAO E, CAMERON H, SCHRADLE K, SIMEONE D M, ZHEN D B. Anal. Chem., 2019, 91(12): 7516-7523.

    67. [67]

      YIN K, ZENG X, LIU W, XUE Y, LI X, WANG W, SONG Y, ZHU Z, YANG C. Anal. Chem., 2019, 91(9): 6003-6011.

    68. [68]

      LI J, QIU Y, ZHANG Z, LI C, LI S, ZHANG W, GUO Z, YAO J, ZHOU L. Analyst, 2020, 145(8): 3116-3124.

    69. [69]

      GENG Z, LI S, ZHU L, CHENG Z, JIN M, LIU B, GUO Y, LIU P. Anal. Chem., 2020, 92(10): 7240-7248.

    70. [70]

      KIM C J, PARK J, SUNKARA V, KIM T H, LEE Y, LEE K, KIM M H, CHO Y K. Lab Chip, 2018, 18(9): 1320-1329.

    71. [71]

      DU Y, DONG S. Anal. Chem., 2017, 89(1): 189-215.

    72. [72]

      WANG Z, YU R, ZENG H, WANG X, LUO S, LI W, LUO X, YANG T. Microchim. Acta, 2019, 186(7): 405.

    73. [73]

      BARTOSIK M, JIRAKOVA L. Curr. Opin. Electrochem., 2019, 14: 96-103.

    74. [74]

      CHU Y L, CAI B, MA Y, ZHAO M G, YE Z Z, HUANG J Y. RSC Adv., 2016, 6(27): 22673-22678.

    75. [75]

      CHEN F, WANG X Y, CAO X W, ZHAO Y X. Anal. Chem., 2017, 89(19): 10468-10473.

    76. [76]

      WANG X, CHEN F, ZHANG D, ZHAO Y, WEI J, WANG L, SONG S, FAN C, ZHAO Y. Chem. Sci., 2017, 8(7): 4764-4770.

    77. [77]

      WANG H F, MA R N, SUN F, JIA L P, ZHANG W, SHANG L, XUE Q W, JIA W L, WANG H S. Biosens. Bioelectron., 2018, 122: 224-230.

    78. [78]

      YANG J M, YIN X S, ZHANG W. Anal. Methods, 2019, 11(2): 157-162.

    79. [79]

      LIU Y, FAN Z J, ZHOU Y, LIN J Y, YANG Y, YAN L, LI Y L, JIANG L, YANG F, HU Q Y, YU J, CHEN L Y, LIAO Y H. Sens. Actuators, B, 2019, 301: 127088.

    80. [80]

      RAHMAN M, CUI D X, ZHOU S K, ZHANG A, CHEN D. Anal. Methods, 2020, 12(4): 440-447.

    81. [81]

      WANG X, WU J, MAO W, HE X, RUAN L, ZHU J, SHU P, ZHANG Z, JIANG B, ZHANG X. Analyst, 2020, 145(13): 4671-4679.

    82. [82]

      KOO K M, DEY S, TRAU M. ACS Sens., 2018, 3(12): 2597-2603.

    83. [83]

      KOO K M, TRAU M. ACS Sens., 2020, 5(10): 3217-3225.

    84. [84]

      DAS J, IVANOV I, MONTERMINI L, RAK J, SARGENT E H, KELLEY S O. Nat. Chem., 2015, 7(7): 569-575.

    85. [85]

      DAS J, IVANOV I, SARGENT E H, KELLEY S O. J. Am. Chem. Soc., 2016, 138(34): 11009-11016.

    86. [86]

      DAS J, IVANOV I, SAFAEI T S, SARGENT E H, KELLEY S O. Angew. Chem., Int. Ed., 2018, 57(14): 3711-3716.

    87. [87]

      DAS J, KELLEY S O. Angew. Chem., Int. Ed., 2020, 59(7): 2554-2564.

    88. [88]

      DEKALIUK M, QIU X, TROALEN F, BUSSON P, HILDEBRANDT N. ACS Sens., 2019, 4(10): 2786-2793.

    89. [89]

      ANAZAWA T, MATSUNAGA H, YAMAMOTO S, INABA R. Lab Chip, 2020, 20(6): 1083-1091.

    90. [90]

      ZHOU W T, WANG L, LIU C, TENG Q Y, WANG Z Y, DAI Z H. Chem. Sci., 2020, 11(14): 3745-3751.

    91. [91]

      LIU G X, MA X Y, TANG Y G, MIAO P. Analyst, 2020, 145(4): 1174-1178.

    92. [92]

      UHD J, MIOTKE L, JI H P, DUNAEVA M, PRUIJN G J M, JORGENSEN C D, KRISTOFFERSEN E L, BIRKEDAL V, YDE C W, NIELSEN F C, HANSEN J, ASTAKHOVA K. Analyst, 2020, 145(17): 5836-5844.

    93. [93]

      CHEN C H, HE R X, ZHANG Z T, CHEN Y. Analyst, 2020, 145(23): 7603-7608.

    94. [94]

      VARONA M, EITZMANN D R, PAGARIYA D, ANAND R K, ANDERSON J L. Anal. Chem., 2020, 92(4): 3346-3353.

    95. [95]

      WEE E J H, WANG Y L, TSAO S C H, TRAU M. Theranostics, 2016, 6(10): 1506-1513.

    96. [96]

      ZHOU Q, ZHENG J, QING Z, ZHENG M, YANG J, YANG S, YING L, YANG R. Anal. Chem., 2016, 88(9): 4759-4765.

    97. [97]

      LIN D, GONG T, HONG Z Y, QIU S, PAN J, TSENG C Y, FENG S, CHEN R, KONG K V. Anal. Chem., 2018, 90(12): 7139-7147.

    98. [98]

      ZHANG J, DONG Y, ZHU W, XIE D, ZHAO Y, YANG D, LI M. ACS Appl. Mater. Interfaces, 2019, 11(20): 18145-18152.

    99. [99]

      MACDONALD D, SMITH E, FAULDS K, GRAHAM D. Analyst, 2020, 145(5): 1871-1877.

    100. [100]

      ZHOU W, GAO X, LIU D, CHEN X. Chem. Rev., 2015, 115(19): 10575-10636.

    101. [101]

      SYEDMORADI L, DANESHPOUR M, ALVANDIPOUR M, GOMEZ F A, HAJGHASSEM H, OMIDFAR K. Biosens. Bioelectron., 2017, 87: 373-387.

    102. [102]

      TANG L, LI J. ACS Sens., 2017, 2(7): 857-875.

    103. [103]

      WU Y, ZHOU Y, LENG Y, LAI W, HUANG X, XIONG Y. Biosens. Bioelectron., 2020, 157: 112168.

    104. [104]

      NGUYEN A H, SIM S J. Biosens. Bioelectron., 2015, 67: 443-449.

    105. [105]

      SINA A A, CARRASCOSA L G, LIANG Z, GREWAL Y S, WARDIANA A, SHIDDIKY M J A, GARDINER R A, SAMARATUNGA H, GANDHI M K, SCOTT R J, KORBIE D, TRAU M. Nat. Commun., 2018, 9(1): 4915.

    106. [106]

      TADIMETY A, ZHANG Y, KREADY K M, PALINSKI T J, TSONGALIS G J, ZHANG J X J. Biosens. Bioelectron., 2019, 130: 236-244.

    107. [107]

      UDAYAN G, MARSELLA A, VALENTINI P. Nanoscale, 2020, 12(5): 2973-2979.

    108. [108]

      WANG Y S, KONG S L, SU X D. RSC Adv., 2020, 10(3): 1476-1483.

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  • 收稿日期:  2021-02-04
  • 修回日期:  2021-03-31
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