纳米孔道限域的单体光电测量

引用本文: 王凌远, 王浩炜, 芦思珉, 龙亿涛. 纳米孔道限域的单体光电测量[J]. 分析化学, 2021, 49(7): 1166-1175. doi: 10.19756/j.issn.0253-3820.211041 shu

Citation: WANG Ling-Yuan, WANG Hao-Wei, LU Si-Min, LONG Yi-Tao. Single-entity Measurement Based on Electro-optical Confinement of Nanopores[J]. Chinese Journal of Analytical Chemistry, 2021, 49(7): 1166-1175. doi: 10.19756/j.issn.0253-3820.211041 shu

纳米孔道限域的单体光电测量

南京大学化学化工学院, 生命分析化学国家重点实验室, 南京 210023

通讯作者: 芦思珉,E-mail:simin_lu@nju.edu.cn; 龙亿涛,E-mail:yitaolong@nju.edu.cn

基金项目:
南京大学国家大学生创新训练计划项目（No.202010284101Z）资助。

摘要: 纳米孔道分析是一种无标记、高通量、高时空分辨的电化学测量技术，被广泛用于单分子、单颗粒和单细胞等单个体测量。孔道不仅具有纳米尺度的三维几何空间的自然结构，用于限域单个目标分析物，纳米孔道限域效应还可以增强电、电磁等物理场，使孔道本身表现出特殊的零模波导和散射等光学性质。本文简要介绍了纳米孔道电化学分析原理，对其在光电协同测量方面的应用进展进行了综述，对其发展前景进行了展望。

关键词:

English

Single-entity Measurement Based on Electro-optical Confinement of Nanopores

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China

Corresponding author: LU Si-Min, ; LONG Yi-Tao,

Received Date: 18 January 2021
Revised Date: 22 March 2021
Fund Project:
Supported by the National Training Program of Innovational for Undergraduates (No. 202010284101Z).

Abstract: Nanopores technique is a label-free, high-throughput, high-spatial-temporal resolution electrochemical measurement method for single-molecule level analysis, which is widely used for single-entity measurements such as single molecules, single particles, and single cells. Nanopores not only have adjustable three-dimensional space to confine single analytes, but also possess an ability to enhance the electrical and magnetic fields. In short, the nanopores exhibit unique sub-wavelength optical properties. In this review, we introduce the principle of nanopore electrochemical analysis, and give a perspective and detailed overview of its application in electro-optical binding measurements.

Key words:

1. [1]
  YING Y L, WANG J J, LEACH A R, JIANG Y, LONG Y T. Sci. China: Chem., 2020, 63(5): 589-618.YING Y L, WANG J J, LEACH A R, JIANG Y, LONG Y T. Sci. China: Chem., 2020, 63(5): 589-618.
2. [2]
  BAKER L A. J. Am. Chem. Soc., 2018, 140(46): 15549-15559.BAKER L A. J. Am. Chem. Soc., 2018, 140(46): 15549-15559.
3. [3]
  EDWARDS M, ROBINSON D, REN H, CHEYNE C G, TAN C S, WHITE H S. Faraday Discuss., 2018, 210: 9-28.EDWARDS M, ROBINSON D, REN H, CHEYNE C G, TAN C S, WHITE H S. Faraday Discuss., 2018, 210: 9-28.
4. [4]
  LU S M, PENG Y Y, YING Y L, LONG Y T. Anal. Chem., 2020, 92(8): 5621-5644.LU S M, PENG Y Y, YING Y L, LONG Y T. Anal. Chem., 2020, 92(8): 5621-5644.
5. [5]
  YING Y L, LONG Y T. J. Am. Chem. Soc., 2019, 141(40): 15720-15729.YING Y L, LONG Y T. J. Am. Chem. Soc., 2019, 141(40): 15720-15729.
6. [6]
  REINER J E, BALIJEPALLI A, ROBERTSON J W, CAMPELL J, SUEHLE J, KASIANOWICZ J J. Chem. Rev., 2012, 112(12): 6431-6451.REINER J E, BALIJEPALLI A, ROBERTSON J W, CAMPELL J, SUEHLE J, KASIANOWICZ J J. Chem. Rev., 2012, 112(12): 6431-6451.
7. [7]
  OSTOLAZA H, BAKAS L, GONI F. J. Membr. Biol., 1997, 158(2): 137-145.OSTOLAZA H, BAKAS L, GONI F. J. Membr. Biol., 1997, 158(2): 137-145.
8. [8]
  CAO C, LONG Y T. Acc. Chem. Res., 2018, 51(2): 331-341.CAO C, LONG Y T. Acc. Chem. Res., 2018, 51(2): 331-341.
9. [9]
  CARLSEN A T, ZAHID O K, RUZICKA J, TAYLOR E W, HALL A R. ACS Nano, 2014, 8(5): 4754-4760.CARLSEN A T, ZAHID O K, RUZICKA J, TAYLOR E W, HALL A R. ACS Nano, 2014, 8(5): 4754-4760.
10. [10]
  KOWALCZYK S W, GROSBERG A Y, RABIN Y, DEKKER C. Nanotechnology, 2011, 22(31): 315101.KOWALCZYK S W, GROSBERG A Y, RABIN Y, DEKKER C. Nanotechnology, 2011, 22(31): 315101.
11. [11]
  SHI W Q, FRIEDMAN A K, BAKER L A. Anal. Chem., 2017, 89(1): 157-188.SHI W Q, FRIEDMAN A K, BAKER L A. Anal. Chem., 2017, 89(1): 157-188.
12. [12]
  LU S M, WU X Y, LI M Y, YING Y L, LONG Y T. View, 2020, 1(4): 20200006.LU S M, WU X Y, LI M Y, YING Y L, LONG Y T. View, 2020, 1(4): 20200006.
13. [13]
  CAO C, YING Y L, HU Z L, LIAO D F, TIAN H, LONG Y T. Nat. Nanotechnol., 2016, 11(8): 713-718.CAO C, YING Y L, HU Z L, LIAO D F, TIAN H, LONG Y T. Nat. Nanotechnol., 2016, 11(8): 713-718.
14. [14]
  LI M Y, YING Y L, LONG Y T. Acta Chim. Sin., 2019, 77(10): 984-988.LI M Y, YING Y L, LONG Y T. Acta Chim. Sin., 2019, 77(10): 984-988.
15. [15]
  BRODSKY R A, MUKHINA G L, LI S, NELSON K L, CHINURAZZI P L, BUCKLEY J T, BOROWITZ M J. Am. J. Clin. Pathol., 2000, 114(3): 459-466.BRODSKY R A, MUKHINA G L, LI S, NELSON K L, CHINURAZZI P L, BUCKLEY J T, BOROWITZ M J. Am. J. Clin. Pathol., 2000, 114(3): 459-466.
16. [16]
  LI S, WU X Y, LI M Y, LIU S C, YING Y L, LONG Y T. Small Methods, 2020, 4(11): 2000014.LI S, WU X Y, LI M Y, LIU S C, YING Y L, LONG Y T. Small Methods, 2020, 4(11): 2000014.
17. [17]
  PIGUET F, OULDALI H, PASTORIZA-GALLEGO M, MANIVET P, PELTA J, OUKHALED A. Nat. Commun., 2018, 9: 966.PIGUET F, OULDALI H, PASTORIZA-GALLEGO M, MANIVET P, PELTA J, OUKHALED A. Nat. Commun., 2018, 9: 966.
18. [18]
  WANG Y Q, LI M Y, QIU H, CAO C. Anal. Chem., 2018, 90(13): 7790-7794.WANG Y Q, LI M Y, QIU H, CAO C. Anal. Chem., 2018, 90(13): 7790-7794.
19. [19]
  LI M Y, YING Y L, LI S, LONG Y T. ACS Nano, 2020, 14(10): 12571-12578.LI M Y, YING Y L, LI S, LONG Y T. ACS Nano, 2020, 14(10): 12571-12578.
20. [20]
  HU Z L, YING Y L, HUO M Z, LONG Y T. J. Chem. Educ., 2020, 97(12): 4345-4354.HU Z L, YING Y L, HUO M Z, LONG Y T. J. Chem. Educ., 2020, 97(12): 4345-4354.
21. [21]
  LI J L, STEIN D, MCMULLAN C, BRANTON D, AZIZ M J, GOLOVCHENKO J A. Nature, 2001, 412(6843): 166-169.LI J L, STEIN D, MCMULLAN C, BRANTON D, AZIZ M J, GOLOVCHENKO J A. Nature, 2001, 412(6843): 166-169.
22. [22]
  STORM A, CHEN J, LING X, HENNY Z. Nat. Mater., 2003, 2(8): 537-540.STORM A, CHEN J, LING X, HENNY Z. Nat. Mater., 2003, 2(8): 537-540.
23. [23]
  GILBOA T, ZREHEN A, GIRSAULT A, MELLER A. Sci. Rep., 2018, 8: 9765.GILBOA T, ZREHEN A, GIRSAULT A, MELLER A. Sci. Rep., 2018, 8: 9765.
24. [24]
  YANAGI I, FUJISAKI K, HAMAMURA H, TAKEDA K. J. Appl. Phys., 2017, 121(4): 045301.YANAGI I, FUJISAKI K, HAMAMURA H, TAKEDA K. J. Appl. Phys., 2017, 121(4): 045301.
25. [25]
  SHI X, LI Q, GAO R, SI W. J. Phys. Chem. Lett., 2018, 9(16): 4686-4694.SHI X, LI Q, GAO R, SI W. J. Phys. Chem. Lett., 2018, 9(16): 4686-4694.
26. [26]
  LIU S C, YING Y L, LI W H, WAN Y J. Chem. Sci., 2021, 12(9): 3282-3289.LIU S C, YING Y L, LI W H, WAN Y J. Chem. Sci., 2021, 12(9): 3282-3289.
27. [27]
  LU S M, LONG Y T. TrAC-Trends Anal. Chem., 2019, 117: 39-46.LU S M, LONG Y T. TrAC-Trends Anal. Chem., 2019, 117: 39-46.
28. [28]
  YU R J, YING Y L, GAO R, LONG Y T. Angew. Chem., Int. Ed., 2019, 58(12): 3706-3714.YU R J, YING Y L, GAO R, LONG Y T. Angew. Chem., Int. Ed., 2019, 58(12): 3706-3714.
29. [29]
  PAKHOMOV A G, GIANULIS E, VERNIER P T, SEMENOV L, XIAO S, PAKHOMOV O N. Biochim. Biophys. Acta-Biomembr., 2015, 1848(4): 958-966.PAKHOMOV A G, GIANULIS E, VERNIER P T, SEMENOV L, XIAO S, PAKHOMOV O N. Biochim. Biophys. Acta-Biomembr., 2015, 1848(4): 958-966.
30. [30]
  XUE L, YAMAZAKI H, REN R, WANUNU M, IVANOV A P, EDEL J B. Nat. Rev. Mater., 2020, 5(12): 931-951.XUE L, YAMAZAKI H, REN R, WANUNU M, IVANOV A P, EDEL J B. Nat. Rev. Mater., 2020, 5(12): 931-951.
31. [31]
  LONG Y T. Confining Electrochemistry to Nanopores. Royal Society of Chemistry, 2020.LONG Y T. Confining Electrochemistry to Nanopores. Royal Society of Chemistry, 2020.
32. [32]
  HUANG S, ROMERO-RUIZ M, CASTELL O K,BAYLEY H, WALLACE M. Nat. Nanotechnol., 2015, 10(11): 986-991.HUANG S, ROMERO-RUIZ M, CASTELL O K,BAYLEY H, WALLACE M. Nat. Nanotechnol., 2015, 10(11): 986-991.
33. [33]
  WANG Y Q, WANG Y, DU X Y, YAN S H, ZHANG P K, CHEN H Y, HUANG S. Sci. Adv., 2019, 5(9): eaar3309.WANG Y Q, WANG Y, DU X Y, YAN S H, ZHANG P K, CHEN H Y, HUANG S. Sci. Adv., 2019, 5(9): eaar3309.
34. [34]
  SONI G V, SINGER A, YU Z, SUN Y J, MYNALLY B, MELLAR A. Rev. Sci. Instrum., 2010, 81(1): 014301.SONI G V, SINGER A, YU Z, SUN Y J, MYNALLY B, MELLAR A. Rev. Sci. Instrum., 2010, 81(1): 014301.
35. [35]
  MCNALLY B, SINGER A, YU Z L, SUN Y J, WENG Z P, MELLAR A. Nano Lett., 2010, 10(6): 2237-2244.MCNALLY B, SINGER A, YU Z L, SUN Y J, WENG Z P, MELLAR A. Nano Lett., 2010, 10(6): 2237-2244.
36. [36]
  ANDERSON B N, ASSAD O N, GILBOA T, SQUIRES A. ACS Nano, 2014, 8(11): 11836-11845.ANDERSON B N, ASSAD O N, GILBOA T, SQUIRES A. ACS Nano, 2014, 8(11): 11836-11845.
37. [37]
  CHANSIN G A, MULERO R, HONG J, KIM M, DEMELLO A J, EDEL J B. Nano Lett., 2007, 7(9): 2901-2906.CHANSIN G A, MULERO R, HONG J, KIM M, DEMELLO A J, EDEL J B. Nano Lett., 2007, 7(9): 2901-2906.
38. [38]
  DI FIORI N, SQUIRES A, BAR D, GILBOA T, MOUSTAKAS T D, MELLAR A. Nat. Nanotechnol., 2013, 8(12): 946-951.DI FIORI N, SQUIRES A, BAR D, GILBOA T, MOUSTAKAS T D, MELLAR A. Nat. Nanotechnol., 2013, 8(12): 946-951.
39. [39]
  YING Y L, LI Y J, MEI J, GAO R, HU Y X. Nat. Commun., 2018, 9: 3657.YING Y L, LI Y J, MEI J, GAO R, HU Y X. Nat. Commun., 2018, 9: 3657.
40. [40]
  BETHE H A. Phys. Rev., 1944, 66(7-8): 163.BETHE H A. Phys. Rev., 1944, 66(7-8): 163.
41. [41]
  ZHU P, CRAIGHEAD H G. Annu. Rev. Biophys., 2012, 41: 269-293.ZHU P, CRAIGHEAD H G. Annu. Rev. Biophys., 2012, 41: 269-293.
42. [42]
  LEVENE M J, KORLACH J, TURNER S W, CRAIGHEAD H G, WEBB W W. Science, 2003, 299(5607): 682-686.LEVENE M J, KORLACH J, TURNER S W, CRAIGHEAD H G, WEBB W W. Science, 2003, 299(5607): 682-686.
43. [43]
  RIGNEAULT H, CAPOULADE J, DINTINGER J, WENGER J, BONOD N, POPOV E, EBBESEN T W, LENNE P. Phys. Rev. Lett., 2005, 95(11): 117401.RIGNEAULT H, CAPOULADE J, DINTINGER J, WENGER J, BONOD N, POPOV E, EBBESEN T W, LENNE P. Phys. Rev. Lett., 2005, 95(11): 117401.
44. [44]
  JADHAV V, HOOGERHEIDE D P, KORLACH J, WANUNU M. Nano Lett., 2018, 19(2): 921-929.JADHAV V, HOOGERHEIDE D P, KORLACH J, WANUNU M. Nano Lett., 2018, 19(2): 921-929.
45. [45]
  LARKIN J, HENLEY R Y, JADHAV V, KORLACH J, WANUNU M. Nat. Nanotechnol., 2017, 12(12): 1169-1175.LARKIN J, HENLEY R Y, JADHAV V, KORLACH J, WANUNU M. Nat. Nanotechnol., 2017, 12(12): 1169-1175.
46. [46]
  LARKIN J, FOQUET M, TURNER S W, KORLACH J. Nano Lett., 2014, 14(10): 6023-6029.LARKIN J, FOQUET M, TURNER S W, KORLACH J. Nano Lett., 2014, 14(10): 6023-6029.
47. [47]
  KLUGHAMMER N, DEKKER C. Nanotechnology, 2021, 32(18): 14.KLUGHAMMER N, DEKKER C. Nanotechnology, 2021, 32(18): 14.
48. [48]
  NICOLI F, VERSCHUEREN D, KLEIN M, DEKKER C. Nano Lett., 2014, 14(12): 6917-6925.NICOLI F, VERSCHUEREN D, KLEIN M, DEKKER C. Nano Lett., 2014, 14(12): 6917-6925.
49. [49]
  SHI X, GAO R, YING Y L, SI W, CHEN Y F, LONG Y T. ACS Sens., 2016, 1(9): 1086-1090.SHI X, GAO R, YING Y L, SI W, CHEN Y F, LONG Y T. ACS Sens., 2016, 1(9): 1086-1090.
50. [50]
  ZHANG L, LI Y, LI D W, JING C, CHEN X Y, LV M, HUANG Q, LONG Y T, WILNER I. Angew. Chem., Int. Ed., 2011, 123(30): 6921-6924.ZHANG L, LI Y, LI D W, JING C, CHEN X Y, LV M, HUANG Q, LONG Y T, WILNER I. Angew. Chem., Int. Ed., 2011, 123(30): 6921-6924.
51. [51]
  EBBESEN T W, LEZEC H J, GHAEMI H, THIO TM WOLFF P A. Nature, 1998, 391(6668): 667-669.EBBESEN T W, LEZEC H J, GHAEMI H, THIO TM WOLFF P A. Nature, 1998, 391(6668): 667-669.
52. [52]
  JONSSON M P, DEKKER C. Nano Lett., 2013, 13(3): 1029-1033.JONSSON M P, DEKKER C. Nano Lett., 2013, 13(3): 1029-1033.
53. [53]
  SHI X, VERSCHUEREN D, PUD S, DEKKER C. Small, 2018, 14(18): 1703307.SHI X, VERSCHUEREN D, PUD S, DEKKER C. Small, 2018, 14(18): 1703307.
54. [54]
  SHI X, VERSCHUEREN D V, DEKKER C. Nano Lett., 2018, 18(12): 8003-8010.SHI X, VERSCHUEREN D V, DEKKER C. Nano Lett., 2018, 18(12): 8003-8010.
55. [55]
  VERSCHUEREN D, SHI X, DEKKER C. Small Methods, 2019, 3(5): 1800465.VERSCHUEREN D, SHI X, DEKKER C. Small Methods, 2019, 3(5): 1800465.
56. [56]
  BELKIN M, CHAO S H, JONSSON M P, DEKKER C, AKSIMENTIEV A. ACS Nano, 2015, 9(11): 10598-10611.BELKIN M, CHAO S H, JONSSON M P, DEKKER C, AKSIMENTIEV A. ACS Nano, 2015, 9(11): 10598-10611.
57. [57]
  PUD S, VERSCHUEREN D, VUKOVIC N, PLESA C, JOSSON M P, DEKKER C. Nano Lett., 2015, 15(10): 7112-7117.PUD S, VERSCHUEREN D, VUKOVIC N, PLESA C, JOSSON M P, DEKKER C. Nano Lett., 2015, 15(10): 7112-7117.
58. [58]
  CRICK C R, ALBELLA P, NG B, ROSCHUK T, EDEL J B. Nano Lett., 2015, 15(1): 553-559.CRICK C R, ALBELLA P, NG B, ROSCHUK T, EDEL J B. Nano Lett., 2015, 15(1): 553-559.
59. [59]
  FREEDMAN K J, CRICK C R, ALBELLA P, BARIK A, IVANOV A P, MAIER S A, OH S H, EDEL J B. ACS Photonics, 2016, 3(6): 1036-1044.FREEDMAN K J, CRICK C R, ALBELLA P, BARIK A, IVANOV A P, MAIER S A, OH S H, EDEL J B. ACS Photonics, 2016, 3(6): 1036-1044.
60. [60]
  CAO J, LIU H L, YANG J M, LI Z Q, YANG D R, JI L N, WANG K, XIA X H. ACS Sens., 2020, 5(7): 2198-2204.CAO J, LIU H L, YANG J M, LI Z Q, YANG D R, JI L N, WANG K, XIA X H. ACS Sens., 2020, 5(7): 2198-2204.
61. [61]
  YING Y L, LI Z Y, HU Z L, ZHANG J J, MENG F N, CAO C, LONG Y T, TIAN H. Chem, 2018, 4(8): 1893-1901.YING Y L, LI Z Y, HU Z L, ZHANG J J, MENG F N, CAO C, LONG Y T, TIAN H. Chem, 2018, 4(8): 1893-1901.
62. [62]
  HU Z L, LI Z Y, YING Y L, ZHANG J J, CAO C, LONG Y T, TIAN H. Anal. Chem., 2018, 90(7): 4268-4272.HU Z L, LI Z Y, YING Y L, ZHANG J J, CAO C, LONG Y T, TIAN H. Anal. Chem., 2018, 90(7): 4268-4272.
63. [63]
  YING Y L, ZHANG J J, MENG F N, CAO C, YAO X Y, WILLNER I, TIAN H, LONG Y T. Sci. Rep., 2013, 3: 1662.YING Y L, ZHANG J J, MENG F N, CAO C, YAO X Y, WILLNER I, TIAN H, LONG Y T. Sci. Rep., 2013, 3: 1662.
64. [64]
  LI P, XIE G H, KONG X Y, ZHANG Z, XIAO K, WEN L P, JIANG L. Angew. Chem., Int. Ed., 2016, 55(50): 15637-15641.LI P, XIE G H, KONG X Y, ZHANG Z, XIAO K, WEN L P, JIANG L. Angew. Chem., Int. Ed., 2016, 55(50): 15637-15641.
65. [65]
  ZHANG X, ZHANG J J, YING Y L, TIAN H, LONG Y T. Chem. Sci., 2014, 5(7): 2642-2646.ZHANG X, ZHANG J J, YING Y L, TIAN H, LONG Y T. Chem. Sci., 2014, 5(7): 2642-2646.
66. [66]
  QIN L X, LI Y, LI D W, JING C, CHEN B Q, MA W, HEYMAN A, SHOSEYOV O, WILLNER I, TIAN H, LONG Y T. Angew. Chem., Int. Ed., 2012, 124(1): 144-148.QIN L X, LI Y, LI D W, JING C, CHEN B Q, MA W, HEYMAN A, SHOSEYOV O, WILLNER I, TIAN H, LONG Y T. Angew. Chem., Int. Ed., 2012, 124(1): 144-148.
67. [67]
  LIU G L, LEE L P. Appl. Phys. Lett., 2005, 87(7): 074101.LIU G L, LEE L P. Appl. Phys. Lett., 2005, 87(7): 074101.

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1.
沈阳化工大学材料科学与工程学院沈阳 110142

纳米孔道限域的单体光电测量

通讯作者: 芦思珉,E-mail:simin_lu@nju.edu.cn; 龙亿涛,E-mail:yitaolong@nju.edu.cn

English

Single-entity Measurement Based on Electro-optical Confinement of Nanopores

Corresponding author: LU Si-Min, ; LONG Yi-Tao,

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

纳米孔道限域的单体光电测量

通讯作者: 芦思珉,E-mail:simin_lu@nju.edu.cn; 龙亿涛,E-mail:yitaolong@nju.edu.cn

English

Single-entity Measurement Based on Electro-optical Confinement of Nanopores

Corresponding author: LU Si-Min, ; LONG Yi-Tao,

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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通讯作者: 陈斌, bchen63@163.com

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