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基于单细胞RNA测序技术的皮肤学研究进展

蔺元斌 ,  吕天琦 ,  王宇辉 ,  李琳 ,  吴爱国 ,  曹张磊 ,  郑建萍

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引用本文: 蔺元斌, 吕天琦, 王宇辉, 李琳, 吴爱国, 曹张磊, 郑建萍. 基于单细胞RNA测序技术的皮肤学研究进展[J]. 分析化学, 2022, 50(7): 985-994. doi: 10.19756/j.issn.0253-3820.210722 shu
Citation:  LIN Yuan-Bin,  LYU Tian-Qi,  WANG Yu-Hui,  LI Lin,  WU Ai-Guo,  CAO Zhang-Lei,  ZHENG Jian-Ping. Research Progress of Single-cell RNA Sequencing Technology in Dermatological Applications[J]. Chinese Journal of Analytical Chemistry, 2022, 50(7): 985-994. doi: 10.19756/j.issn.0253-3820.210722 shu

基于单细胞RNA测序技术的皮肤学研究进展

  • 1.

    中国科学院宁波材料技术与工程研究所慈溪生物医学工程研究所, 宁波 315300;

  • 2.

    上海大学材料科学与工程学院, 上海 200444

    • 通讯作者: 曹张磊,E-mail:caozhanglei@nimte.ac.cn; 郑建萍,E-mail:zhengjianping@nimte.ac.cn
  • 基金项目:

    浙江省自然科学基金项目(No.LY20B050003)、宁波市3315创新团队项目(No.2019A-14-C)和宁波市科技重大专项项目(No.2016C50009)资助。

摘要: 单细胞RNA测序技术是近年发展起来的一种高通量测序技术,该技术可在单个细胞层面上研究细胞基因表达和识别细胞异质性,极大地拓宽了研究者对皮肤发育、肿瘤产生和免疫应答等皮肤生物学机制的理解。近年来,皮肤方面的单细胞RNA测序研究系统地揭示了皮肤细胞的异质性,阐明了一些皮肤病的发病机制,并确定了多种临床皮肤病潜在的新型治疗靶点,为皮肤病的诊断和治疗提供了指导。本文详细综述了单细胞RNA测序技术和该技术在皮肤学领域中的最新研究进展,并探讨了该领域未来面临的主要挑战和发展的前景。

English


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  • 收稿日期:  2021-09-13
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