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基于呼出气挥发性有机物检测的肺癌筛查技术研究进展

李杨 ,  李庆运 ,  徐楚婷 ,  阮慧文 ,  赵琨 ,  花磊 ,  李海洋

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引用本文: 李杨, 李庆运, 徐楚婷, 阮慧文, 赵琨, 花磊, 李海洋. 基于呼出气挥发性有机物检测的肺癌筛查技术研究进展[J]. 分析化学, 2022, 50(2): 183-197. doi: 10.19756/j.issn.0253-3820.210617 shu
Citation:  LI Yang,  LI Qing-Yun,  XU Chu-Ting,  RUAN Hui-Wen,  ZHAO Kun,  HUA Lei,  LI Hai-Yang. Research Progress of Lung Cancer Screening Technology Based on Detection of Exhaled Volatile Organic Compounds[J]. Chinese Journal of Analytical Chemistry, 2022, 50(2): 183-197. doi: 10.19756/j.issn.0253-3820.210617 shu

基于呼出气挥发性有机物检测的肺癌筛查技术研究进展

  • 1.

    中国科学院大连化学物理研究所, 中国科学院分离分析化学重点实验室, 大连 116023;

  • 2.

    大连市呼出气诊断技术工程研究中心, 大连 116023;

  • 3.

    大连市在线谱学分析仪器重点实验室, 大连 116023;

  • 4.

    呼吸代谢研究中心, 北京 100074

    • 通讯作者: 花磊,E-mail:hli@dicp.ac.cn; 李海洋,E-mail:lhua@dicp.ac.cn
  • 基金项目:

    国家自然科学基金项目（No.22027804）、辽宁省“兴辽英才计划”项目（No.XLYC1808022）和大连市高层次人才创新支持计划项目（No.2019RQ101）资助

摘要: 肺癌已成为当前全球发病率和死亡率最高的癌症。早期肺癌的治愈率高，“早诊早治”已成为共识。呼出气检测具有非侵入性、取样方便且对人体友好的优势，通过对呼出气中特征代谢物的检测，寻找早期肺癌的疾病标志物，有望作为一种简单有效的早期肺癌筛查手段而备受关注。本文从临床常用肺癌筛查方法、呼出气组分及肺癌标志性挥发性有机物(VOCs)种类、呼出气VOCs收集方法、前处理方法以及肺癌标志性VOCs检测技术等方面，评述了基于呼出气VOCs检测的肺癌早期筛查技术的研究进展，并对其存在的问题和未来发展趋势进行了分析和展望。

English


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  • 收稿日期:  2021-07-09
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