纳米酶及其在生物医学检测领域的研究进展

引用本文: 尉枫, 韩晓军. 纳米酶及其在生物医学检测领域的研究进展[J]. 分析化学, 2021, 49(4): 581-592. doi: 10.19756/j.issn.0253-3820.201491 shu

Citation: WEI Feng, HAN Xiao-Jun. Nanozymes and Their Application Progress in Biomedical Detection[J]. Chinese Journal of Analytical Chemistry, 2021, 49(4): 581-592. doi: 10.19756/j.issn.0253-3820.201491 shu

纳米酶及其在生物医学检测领域的研究进展

尉枫 ,
韩晓军 ^,

城市水资源与水环境国家重点实验室, 哈尔滨工业大学化学与化工学院, 哈尔滨 150001

通讯作者: 韩晓军,E-mail:hanxiaojun@hit.edu.cn

基金项目:
国家重点研发计划项目（No.2016YFC0401104）、哈尔滨市杰出青年基金项目（No.2017RAYXJ024）和城市水资源与水环境国家重点实验室项目（No.2020DX03）资助。

摘要: 天然酶是高度特异性的生物催化剂，可通过选择性催化特定反应而达到识别和检测的目的。然而，天然酶制备成本高、易失活，限制了其实际应用。纳米酶是一类具有类酶活性的纳米材料，可通过无机材料自身的催化活性实现模拟酶的仿生催化功能，具有价格低廉、性能稳定、应用范围广泛等优点。基于纳米酶的生物医学检测具有灵敏度高、特异性强、检出限低等特点，展现出良好的发展前景。本文总结了目前主流的纳米酶材料，介绍了其在生物医学检测领域的研究进展，并展望了纳米酶在生物医学检测领域的发展方向。

关键词:

English

Nanozymes and Their Application Progress in Biomedical Detection

WEI Feng ,
HAN Xiao-Jun ^,

State Key Laboratory of Urban Water Resource and Environment, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China

Corresponding author: HAN Xiao-Jun, hanxiaojun@hit.edu.cn

Received Date: 14 August 2020
Revised Date: 01 December 2020
Fund Project:
Supported by the National Key R&D Program of China (No.2016YFC0401104), the Harbin Distinguished Young Scholars Fund (No.2017RAYXJ024), and the State Key Laboratory of Urban Water Resource and Environment (Harbin Institute of Technology) (No.2020DX03).

Abstract: As a kind of biocatalyst with high specificity, natural enzymes can be applied in recognition and detection by selective catalysis. However, the high cost and easy inactivation limit their practical applications. Nanozyme is a kind of nanomaterial which can mimic enzyme-like properties via the instinct ability, with many advantages such as low cost, stable performance and wide applications. The biomedical detection based on nanozymes with high sensitivity, excellent specificity and low limit of detection is promising. In this paper, several main types of nanozymes were summarized, followed by the introduction of their research progress in biomedical detection. The outlook of nanozymes in biomedical detection was also proposed at the end of this paper.

Key words:

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

纳米酶及其在生物医学检测领域的研究进展

通讯作者: 韩晓军,E-mail:hanxiaojun@hit.edu.cn

English

Nanozymes and Their Application Progress in Biomedical Detection

Corresponding author: HAN Xiao-Jun, hanxiaojun@hit.edu.cn

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

纳米酶及其在生物医学检测领域的研究进展

通讯作者: 韩晓军,E-mail:hanxiaojun@hit.edu.cn

English

Nanozymes and Their Application Progress in Biomedical Detection

Corresponding author: HAN Xiao-Jun, hanxiaojun@hit.edu.cn

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

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