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Microwave-assistant Syntheses, Crystal Structures and Safener Activities of Two Substituted Phenyl Isoxazole Derivatives

Ying-Chao GAO ,  Xin-Xin SHAO ,  Ying FU

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Citation:  Ying-Chao GAO, Xin-Xin SHAO, Ying FU. Microwave-assistant Syntheses, Crystal Structures and Safener Activities of Two Substituted Phenyl Isoxazole Derivatives[J]. Chinese Journal of Structural Chemistry, 2021, 40(9): 1231-1237. doi: 10.14102/j.cnki.0254–5861.2011–3142 shu

Microwave-assistant Syntheses, Crystal Structures and Safener Activities of Two Substituted Phenyl Isoxazole Derivatives

English

  • 1. INTRODUCTION

    With the expansion of herbicides application, the safety issues have become serious, especially the excessive use of herbicides or damage to sensitive crops[1]. Herbicide safeners are regarded as a very effective way to solve these problems[2, 3]. In recent years, some safeners have been subsequently commercialized for different types of herbicides[4], such as isoxadifen-ethyl[5] and mefenpyr-diethyl[6].

    Isoxadifen-ethyl, as a new safener for sulfonylurea herbicides, was launched by Bayer Crop Science AG in 2002[7]. It effectively alleviates the phytotoxicity of nicosulfuron to maize and increases the metabolism of nicosulfuron through non-cytochrome P450-catalyzed routes[8]. Andreas gave the mechanism of exogenous detoxification induced by isoxadifen-ethyl through multiple signaling channels in plants[9]. Benoxacor, which has been commercialized by Ciba-Geigy, is widely used to protect maize and sorghum from metolachlor and increases crops resistance to herbicides[10, 11]. As an effective ingredient of chloroacetamide herbicide safener, it usually induces the hydroxylation of primisulfuron-methyl and increases glutathione (GSH) conjugation of metolachlor, metazachlor and acetochlor to achieve the detoxification effect[12-14].

    As a part of our ongoing interest in nitrogen-containing heterocyclic herbicide safeners[15-19], two novel substituted phenyl isoxazole derivatives were designed via active subunits combination with isoxadifen-ethyl and benoxacor (Fig. 1). The synthesis was carried out under microwave irradiation (Scheme 1)[20-24]. The single crystal structure was confirmed by X-ray diffraction analysis. Biological activities as safener of the target compounds were evaluated on maize in vivo.

    Figure 1

    Figure 1.  Skeleton structure of the template compound
    DownLoad: Full-Size Img PowerPoint

    Scheme 1

    Scheme 1.  Synthetic route of compounds 4a and 4b
    DownLoad: Full-Size Img PowerPoint

    2. EXPERIMENTAL

    2.1 Materials and characterization

    The chemicals involved in experiment were analytically pure and applied without purification. The melting points were obtained on a Beijing Taike point instrument (X-4) and uncorrected. IR spectra were measured on a Bruker ALPHA-T spectrometer (in KBr pallets). The NMR spectrum was collected on a Bruker AV-400 spectrometer with CDCl3 as solvent and TMS as internal standard. High-resolution mass spectrometry (HRMS) data were recorded using a Varian QFT-ESI instrument. Microwave irradiation was carried out with XH100A focused microwave. Crystallogra-phic data of the compound were measured on a Rigaku R-AXIS RAPID area-detector diffractometer.

    2.2 Preparation of benzoxazine derivatives (3)

    o-Aminophenol 1 (15 mmol), DMSO (40 mL) and K2CO3 (5 equivalents, 20 mmol) were added to 1, 2-dibromoethane 2 (22 mmol) in sequence. The reaction conditions were optimized by a preliminary test (800 W, 85 ℃, and 20 min)[25]. When the reaction was completed (monitored by TLC), the solution was cooled to room temperature and filtered. The mixture was extracted with ethyl acetate and the organic phase was dried. Then the solvent was removed by rotary evaporation. The crude product was purified on silica gel by column chromatography (V(ethyl acetate): V(petroleum ether) = 1:9) to obtain compound 3.

    The infrared spectrum analysis of intermediates 3a and 3b shows that the absorption peaks at 3383 and 3356 cm-1 are the N–H stretching vibration peak of the benzoxazine ring, which indicates that the synthesis of the intermediate is correct.

    2.3 Preparation of phenyl isoxazole benzoxazine formamide derivative (4)

    Compound 3 (0.05 mol), substituted phenyl isoxazole carbonyl chloride (0.06 mol) and anhydrous K2CO3 (5 eq., 0.38 g) were mixed in toluene (40 mL). Then, the mixture was placed in a microwave catalytic synthesizer (800 W, 40 ℃, and 25 min)[26]. After the reaction was completed, the solution was cooled to room temperature and filtered. The crude product was purified on silica gel by column chromatography (V(ethyl acetate): V(petroleum ether) = 1:6) to obtain the target compounds 4.

    3-(2΄-Chloro-6΄-fluoro-phenyl)-4-(2΄, 3΄-dihydro-1΄, 4΄-benzoxazine)-5-methyl-isoxazole formamide (4a) White crystal; m.p. 181.5~182.2 ℃; yield, 43.2%; IR (KBr, cm-1) ν: 3053~2870 (C–H), 1631 (C=O). 1H NMR (400 MHz, CDCl3, ppm) δ: 7.30~6.66 (m, 7H, Ar–H), 4.27~3.85 (m, 4H, O–CH2CH2–N), 2.58 (s, 3H, -CH3); 13C NMR (100MHz, CDCl3, ppm) δ: 172.31, 161.59, 153.92, 145.94, 134.34, 131.71, 131.62, 126.10, 125.50, 125.47, 122.34, 120.78, 117.16, 114.72, 114.50, 113.46, 66.06, 41.04, 12.45; HRMS (ESI): C19H14ClFN2O3 calculated for [M+H]+ 373.0750, found 373.0754.

    3-Phenyl-4-(6-methyl-2΄, 3΄-dihydro-1΄, 4΄-benzoxazine)-5-methyl-isoxazole formamide (4b) White crystal; m.p. 125.8~127.6 ℃; yield, 75.5%; IR (KBr, cm-1) ν: 3004~2860 (C–H), 1638 (C=O). 1H NMR (400 MHz, CDCl3, ppm) δ: 7.40~7.34 (m, 4H, Ar–H), 7.29~6.46 (m, 4H, Ar–H), 4.15~3.57 (m, 4H, O–CH2CH2–N), 2.56 (s, 3H, -CH3), 2.17 (s, 3H, -CH3), 13C NMR (100MHz, CDCl3, ppm) δ: 171.18, 160.64, 160.61, 144.24, 129.99, 129.96, 129.42, 128.86, 128.21, 127.37, 127.37, 127.01, 127.01, 123.22, 112.12, 111.76, 65.61, 20.70, 12.08, 12.08; HRMS (ESI): C20H18N2O3 calculated for [M+H]+ 337.1210, found 337.1213.

    2.4 Crystal structure determination

    Crystals (4a and 4b) suitable for X-ray analysis were obtained by the slow evaporation method with ethyl acetate as solvent at room temperature. The X-ray data were collected on a Rigaku RAXIS-RAPID diffractometer (Japan) with MoKα radiation (λ = 0.71073 Å) at 293(2) K. The structure was solved by direct methods using SHELXS-97[26] and refined with SHELXL-97[27]. The hydrogen atoms were included in calculated positions, and refined in terms of riding model (Uiso(H) = 1.5Ueq(C) for the atoms of methyl and Uiso(H) = 1.2Ueq(C) for others). Selected bond lengths and bond angles are listed in Table 1, and hydrogen bond parameters are summarized in Table 2.

    Table 1

    Table 1.  Selected Bond Lengths (Å) and Bond Angles (°) for the Crystals of 4a and 4b
    DownLoad: CSV
    4a 4b
    Bond Dist. Bond Dist. Bond Dist. Bond Dist.
    C(1)–C(2) 1.373(4) C(12)–N(2) 1.422(2) C(1)–C(2) 1.399(6) C(12)–N(2) 1.478(4)
    C(1)–C(6) 1.391(3) C(12)–C(13) 1.387(2) C(1)–C(6) 1.370(5) C(12)–C(13) 1.487(5)
    C(1)–F(1) 1.386(3) C(12)–C(17) 1.396(2) C(2)–C(3) 1.384(6) C(13)–O(3) 1.430(4)
    C(2)–C(3) 1.371(5) C(13)–C(14) 1.385(3) C(3)–C(4) 1.375(7) C(14)–O(3) 1.370(4)
    C(3)–C(4) 1.366(4) C(14)–C(15) 1.382(3) C(4)–C(5) 1.399(6) C(14)–C(15) 1.383(5)
    C(4)–C(5) 1.379(4) C(15)–C(16) 1.375(3) C(5)–C(6) 1.404(5) C(14)–C(19) 1.398(5)
    C(5)–C(6) 1.396(3) C(16)–C(17) 1.388(3) C(6)–C(7) 1.471(5) C(15)–C(16) 1.381(5)
    C(5)–Cl(1) 1.707(2) C(17)–O(3) 1.367(2) C(7)–N(1) 1.312(4) C(16)–C(17) 1.405(5)
    C(6)–C(7) 1.472(3) C(18)–O(3) 1.426(3) C(7)–C(8) 1.436(5) C(17)–C(18) 1.383(5)
    C(8)–O(1) 1.348(2) C(18)–C(19) 1.501(4) C(8)–C(9) 1.362(5) C(17)–C(20) 1.509(5)
    C(8)–C(9) 1.355(3) C(19)–N(2) 1.467(2) C(9)–O(1) 1.345(4) C(18)–C(19) 1.404(5)
    C(9)–C(11) 1.485(2) N(1)–O(1) 1.409(3) C(9)–C(10) 1.469(6) C(19)–N(2) 1.440(4)
    C(11)–O(2) 1.225(2) C(7)–N(1) 1.310(2) C(11)–O(2) 1.231(4) N(1)–O(1) 1.416(4)
    C(11)–N(2) 1.359(2) C(7)–N(9) 1.424(2) C(11)–N(2) 1.351(4)
    Angle (°) Angle (°) Angle (°) Angle (°)
    C(6)–C(1)–C(2) 123.3(2) O(2)–C(11)–C(9) 119.58(16) C(6)–C(1)–C(2) 121.7(4) C(18)–C(17)–C(16) 118.0(3)
    C(2)–C(1)–F(1) 117.2(2) N(2)–C(11)–C(9) 118.32(16) C(3)–C(2)–C(1) 118.6(4) C(18)–C(17)–C(20) 121.0(4)
    F(1)–C(1)–C(6) 119.49(19) C(13)–C(12)–C(17) 118.32(16) C(4)–C(3)–C(2) 120.2(4) C(16)–C(17)–C(20) 121.1(3)
    C(3)–C(2)–C(1) 118.6(2) C(13)–C(12)–N(2) 123.14(16) C(3)–C(4)–C(5) 121.5(4) C(17)–C(18)–C(19) 122.3(3)
    C(4)–C(3)–C(2) 120.8(2) C(17)–C(12)–N(2) 118.28(15) C(4)–C(5)–C(6) 118.2(4) C(14)–C(19)–C(18) 118.3(3)
    C(3)–C(4)–C(5) 119.6(3) C(14)–C(13)–C(12) 121.22(17) C(1)–C(6)–C(5) 119.7(4) C(14)–C(19)–N(2) 119.1(3)
    C(4)–C(5)–C(6) 122.0(2) C(15)–C(14)–C(13) 119.53(19) C(1)–C(6)–C(7) 112.9(3) C(18)–C(19)–N(2) 122.5(3)
    C(4)–C(5)–Cl(1) 119.2(2) C(16)–C(15)–C(14) 120.24(19) C(5)–C(6)–C(7) 118.4(3) C(7)–N(1)–O(1) 105.9(3)
    C(6)–C(5)–Cl(1) 118.80(16) C(15)–C(16)–C(17) 120.17(19) N(1)–C(7)–C(8) 111.0(3) C(11)–N(2)–C(19) 123.8(3)
    C(1)–C(6)–C(5) 115.6(2) O(3)–C(17)–C(16) 116.09(17) N(1)–C(7)–C(6) 119.5(3) C(11)–N(2)–C(12) 122.7(3)
    C(1)–C(6)–C(7) 121.83(18) O(3)–C(17)–C(12) 123.44(17) C(8)–C(7)–C(6) 129.3(3) C(19)–N(2)–C(12) 112.6(3)
    C(5)–C(6)–C(7) 122.55(17) C(16)–C(17)–C(12) 120.37(18) C(9)–C(8)–C(7) 104.3(3) C(9)–O(1)–N(1) 108.8(3)
    N(1)–C(7)–C(9) 111.37(17) O(3)–C(18)–C(19) 112.1(2) C(9)–C(8)–C(11) 128.0(3) C(14)–O(3)–C(13) 115.1(3)
    N(1)–C(7)–C(6) 120.25(16) N(2)–C(19)–C(18) 107.60(17) C(7)–C(8)–C(11) 126.4(3) N(2)–C(12)–C(13) 100.3(3)
    C(9)–C(7)–C(6) 128.37(15) C(7)–N(1)–O(1) 105.45(16) O(1)–C(9)–C(8) 109.9(3) O(3)–C(13)–C(12) 104.2(3)
    O(1)–C(8)–C(9) 109.27(18) C(11)–N(2)–C(12) 127.09(14) O(1)–C(9)–C(10) 115.6(3) O(3)–C(14)–N(2) 101.6(3)
    O(1)–C(8)–C(10) 117.62(18) C(11)–N(2)–C(19) 118.85(15) C(8)–C(9)–C(10) 134.6(3) O(3)–C(14)–C(16) 108.4(3)
    C(9)–C(8)–C(10) 133.1(2) C(12)–N(2)–C(19) 113.99(14) O(2)–C(11)–N(2) 123.3(3) N(2)–C(14)–C(16) 113.1(3)
    C(8)–C(9)–C(7) 104.71(15) C(8)–O(1)–N(1) 109.19(14) O(2)–C(11)–C(8) 118.8(3) O(3)–C(14)–C(15) 110.2(3)
    C(8)–C(9)–C(11) 125.46(17) C(17)–O(3)–C(18) 116.17(15) N(2)–C(11)–C(8) 117.9(3) N(2)–C(14)–C(15) 111.1(3)
    C(7)–C(9)–C(11) 121.56(15) N(2)–C(12)–C(13) 110.7(3) C(7)–N(1)–O(1) 104.8(2)
    O(3)–C(13)–C(12) 109.8(3) C(11)–N(2)–C(12) 126.2(3)
    O(3)–C(14)–C(15) 116.2(3) C(11)–N(2)–C(14) 122.3(2)
    O(3)–C(14)–C(19) 123.9(3) C(12)–N(2)–C(14) 110.7(3)
    C(15)–C(14)–C(19) 119.9(3) C(9)–O(1)–N(1) 109.6(2)
    C(16)–C(15)–C(14) 121.0(4) C(13)–O(3)–C(14) 107.4(3)
    C(15)–C(16)–C(17) 120.5(3)

    Table 2

    Table 2.  Hydrogen Bond Parameters in the Structures of 4a and 4b
    DownLoad: CSV
    D–H···A d(D–H) d(H···A) d(D···A) ∠DHA
    4a C(11)–H(10A)···O(2)a 0.96 2.30 1.225(2) 169
    C(10)–H(10A)···F(1)b 0.96 2.60 1.386(3) 143
    4b C(3)–H(3)···O(2)c 0.93 2.70 3.463(21) 148
    C(12)–H(12B)···N(1)d 0.97 2.65 3.4080(48) 135
    Symmetry codes: (a) x–0.5, 1.5–x, –z; (b) 1–x, 0.5+y, 0.5–z; (c) 1–x, 2–y, 2–z; (d) 1–x, 1–y, 1–z

    2.5 Biological activity assay

    The title compounds (10 mg) were completely dissolved in ethanol (2 mL), and a small amount of emulsifier was added to make the solution uniform and transparent. The solution was prepared according to the principle of gradual dilution. Maize seeds (Dongnong 259) were soaked in solution (containing compounds 25 μM) overnight, and the control was treated with water. The seeds were then induced to germinate, and sown in paper cups with seven per cup with the soil mixed with acetochlor (20 mg/kg). They were incubated in an incubator (12 h of light, 26.5 ± 1 ℃, 75% relative humidity). The root length, plant height, root fresh weight and plant fresh weight of maize were measured after 7 days[28, 29].

    3. RESULTS AND DISCUSSION

    The molecular structures of compounds 4a and 4b with atom-numbering are shown in Fig. 2. The crystal structure of 4a crystallizes in orthorhombic space group P21, and 4b in triclinic space group P$ \overline 1 $.

    Figure 2

    Figure 2.  Molecular diagram of compounds 4a and 4b, showing 30% probability ellipsoids
    DownLoad: Full-Size Img PowerPoint

    Both of the crystal structures composed three parts: a benzoxazine skeleton (A), an isoxazole ring (B) and a benzene ring (C). For compound 4a, the molecule is not coplanar. The dihedral angles between the benzoxazine skeleton (A), the isoxazole ring (B) and the benzene ring (C) are 60.66° (A/B), 18.57° (A/C), 61.08° (B/C). Obviously, there is π-π conjunctive effect between the isoxazole ring (B) and C(11)=O(2), which causes C(9)–C(11) (1.485(2) Å) shorter than the typical C–C bond (1.54 Å)[30]. And the bond C(11)–N(2) in 1.359(2) Å is shorter than the typical C−N (1.42 Å), indicating a p-π conjunction effect between N(2) and C(11)=O(2). The bond distance of C(12)–N(2) is 1.422(2) Å, similar to the typical C–N bond length, so there is no p-π conjunction effect between the benzene and N(2). There are similar crystal data for 4b. The dihedral angles between the benzoxazine skeleton (A), isoxazole ring (B) and benzene ring (C) are 89.65° (A/B), 88.48° (A/C) and 28.00° (B/C), indicating rings B and C are almost perpendicular to the plane of A. The distances between A and C are 4.1334(6) Å for 4a and 6.5455(18) Å for 4b, longer than the typical π-π conjunction effect distance.

    Hydrogen-bond interactions played a significant role in the crystal packing of 4a and 4b. Compound 4a formed crystal packing via hydrogen bonds C(10)–H(10A)···F(1) and C(11)–H(10A)···O(2), and the crystal packing of 4b was via the C(3)–H(3)···O(2) and C(12)–H(10B)···N(1) hydrogen bonds, as shown in Fig. 3. The presence of hydrogen bonds caused the target compounds to arrange in an ordered manner and form stable single crystal structures with high symmetry and regularity.

    Figure 3

    Figure 3.  Molecular packing diagram of 4a and 4b. Hydrogen bonds are described as dashed lines
    DownLoad: Full-Size Img PowerPoint

    4. BIOLOGICAL ACTIVITIES

    The safener activity of the title compounds was tested with benoxacor selected as the control and acetochlor as the herbicide[31-33]. The recovery rate of various growth indicators of maize was evaluated after being treated with 20 mg/kg acetochlor in soil (Fig. 4). Compounds 4a and 4b showed detoxification effect on maize and could restore the maize growth to some extent. The root fresh weight recovery rates of 4a, 4b and benoxacor are 70.6%, 37.0% and 115.5%, respectively. The root length recovery rate of compound 4a is 72.7%, however, that of 4b is much lower, with the value to be only 37.3%. Compound 4a has much better activity than 4b, possibly caused by the halogen substituents (R2 = Cl, R3 = F) on the phenyl in 4a. Halogen substitution usually enhances the bioactivity of compounds. Both title compounds show good safener activity, although they are not as active as benoxacor, indicating that the skeleton bears certain safener activity, and a new safener scaffold will be obtained with further structure modification.

    Figure 4

    Figure 4.  Safener effects of 4a and 4b against the ACT-induced injury
    DownLoad: Full-Size Img PowerPoint

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  • Figure 1  Skeleton structure of the template compound

    下载: 全尺寸图片 幻灯片

    Scheme 1  Synthetic route of compounds 4a and 4b

    下载: 全尺寸图片 幻灯片

    Figure 2  Molecular diagram of compounds 4a and 4b, showing 30% probability ellipsoids

    下载: 全尺寸图片 幻灯片

    Figure 3  Molecular packing diagram of 4a and 4b. Hydrogen bonds are described as dashed lines

    下载: 全尺寸图片 幻灯片

    Figure 4  Safener effects of 4a and 4b against the ACT-induced injury

    下载: 全尺寸图片 幻灯片

    Table 1.  Selected Bond Lengths (Å) and Bond Angles (°) for the Crystals of 4a and 4b

    4a 4b
    Bond Dist. Bond Dist. Bond Dist. Bond Dist.
    C(1)–C(2) 1.373(4) C(12)–N(2) 1.422(2) C(1)–C(2) 1.399(6) C(12)–N(2) 1.478(4)
    C(1)–C(6) 1.391(3) C(12)–C(13) 1.387(2) C(1)–C(6) 1.370(5) C(12)–C(13) 1.487(5)
    C(1)–F(1) 1.386(3) C(12)–C(17) 1.396(2) C(2)–C(3) 1.384(6) C(13)–O(3) 1.430(4)
    C(2)–C(3) 1.371(5) C(13)–C(14) 1.385(3) C(3)–C(4) 1.375(7) C(14)–O(3) 1.370(4)
    C(3)–C(4) 1.366(4) C(14)–C(15) 1.382(3) C(4)–C(5) 1.399(6) C(14)–C(15) 1.383(5)
    C(4)–C(5) 1.379(4) C(15)–C(16) 1.375(3) C(5)–C(6) 1.404(5) C(14)–C(19) 1.398(5)
    C(5)–C(6) 1.396(3) C(16)–C(17) 1.388(3) C(6)–C(7) 1.471(5) C(15)–C(16) 1.381(5)
    C(5)–Cl(1) 1.707(2) C(17)–O(3) 1.367(2) C(7)–N(1) 1.312(4) C(16)–C(17) 1.405(5)
    C(6)–C(7) 1.472(3) C(18)–O(3) 1.426(3) C(7)–C(8) 1.436(5) C(17)–C(18) 1.383(5)
    C(8)–O(1) 1.348(2) C(18)–C(19) 1.501(4) C(8)–C(9) 1.362(5) C(17)–C(20) 1.509(5)
    C(8)–C(9) 1.355(3) C(19)–N(2) 1.467(2) C(9)–O(1) 1.345(4) C(18)–C(19) 1.404(5)
    C(9)–C(11) 1.485(2) N(1)–O(1) 1.409(3) C(9)–C(10) 1.469(6) C(19)–N(2) 1.440(4)
    C(11)–O(2) 1.225(2) C(7)–N(1) 1.310(2) C(11)–O(2) 1.231(4) N(1)–O(1) 1.416(4)
    C(11)–N(2) 1.359(2) C(7)–N(9) 1.424(2) C(11)–N(2) 1.351(4)
    Angle (°) Angle (°) Angle (°) Angle (°)
    C(6)–C(1)–C(2) 123.3(2) O(2)–C(11)–C(9) 119.58(16) C(6)–C(1)–C(2) 121.7(4) C(18)–C(17)–C(16) 118.0(3)
    C(2)–C(1)–F(1) 117.2(2) N(2)–C(11)–C(9) 118.32(16) C(3)–C(2)–C(1) 118.6(4) C(18)–C(17)–C(20) 121.0(4)
    F(1)–C(1)–C(6) 119.49(19) C(13)–C(12)–C(17) 118.32(16) C(4)–C(3)–C(2) 120.2(4) C(16)–C(17)–C(20) 121.1(3)
    C(3)–C(2)–C(1) 118.6(2) C(13)–C(12)–N(2) 123.14(16) C(3)–C(4)–C(5) 121.5(4) C(17)–C(18)–C(19) 122.3(3)
    C(4)–C(3)–C(2) 120.8(2) C(17)–C(12)–N(2) 118.28(15) C(4)–C(5)–C(6) 118.2(4) C(14)–C(19)–C(18) 118.3(3)
    C(3)–C(4)–C(5) 119.6(3) C(14)–C(13)–C(12) 121.22(17) C(1)–C(6)–C(5) 119.7(4) C(14)–C(19)–N(2) 119.1(3)
    C(4)–C(5)–C(6) 122.0(2) C(15)–C(14)–C(13) 119.53(19) C(1)–C(6)–C(7) 112.9(3) C(18)–C(19)–N(2) 122.5(3)
    C(4)–C(5)–Cl(1) 119.2(2) C(16)–C(15)–C(14) 120.24(19) C(5)–C(6)–C(7) 118.4(3) C(7)–N(1)–O(1) 105.9(3)
    C(6)–C(5)–Cl(1) 118.80(16) C(15)–C(16)–C(17) 120.17(19) N(1)–C(7)–C(8) 111.0(3) C(11)–N(2)–C(19) 123.8(3)
    C(1)–C(6)–C(5) 115.6(2) O(3)–C(17)–C(16) 116.09(17) N(1)–C(7)–C(6) 119.5(3) C(11)–N(2)–C(12) 122.7(3)
    C(1)–C(6)–C(7) 121.83(18) O(3)–C(17)–C(12) 123.44(17) C(8)–C(7)–C(6) 129.3(3) C(19)–N(2)–C(12) 112.6(3)
    C(5)–C(6)–C(7) 122.55(17) C(16)–C(17)–C(12) 120.37(18) C(9)–C(8)–C(7) 104.3(3) C(9)–O(1)–N(1) 108.8(3)
    N(1)–C(7)–C(9) 111.37(17) O(3)–C(18)–C(19) 112.1(2) C(9)–C(8)–C(11) 128.0(3) C(14)–O(3)–C(13) 115.1(3)
    N(1)–C(7)–C(6) 120.25(16) N(2)–C(19)–C(18) 107.60(17) C(7)–C(8)–C(11) 126.4(3) N(2)–C(12)–C(13) 100.3(3)
    C(9)–C(7)–C(6) 128.37(15) C(7)–N(1)–O(1) 105.45(16) O(1)–C(9)–C(8) 109.9(3) O(3)–C(13)–C(12) 104.2(3)
    O(1)–C(8)–C(9) 109.27(18) C(11)–N(2)–C(12) 127.09(14) O(1)–C(9)–C(10) 115.6(3) O(3)–C(14)–N(2) 101.6(3)
    O(1)–C(8)–C(10) 117.62(18) C(11)–N(2)–C(19) 118.85(15) C(8)–C(9)–C(10) 134.6(3) O(3)–C(14)–C(16) 108.4(3)
    C(9)–C(8)–C(10) 133.1(2) C(12)–N(2)–C(19) 113.99(14) O(2)–C(11)–N(2) 123.3(3) N(2)–C(14)–C(16) 113.1(3)
    C(8)–C(9)–C(7) 104.71(15) C(8)–O(1)–N(1) 109.19(14) O(2)–C(11)–C(8) 118.8(3) O(3)–C(14)–C(15) 110.2(3)
    C(8)–C(9)–C(11) 125.46(17) C(17)–O(3)–C(18) 116.17(15) N(2)–C(11)–C(8) 117.9(3) N(2)–C(14)–C(15) 111.1(3)
    C(7)–C(9)–C(11) 121.56(15) N(2)–C(12)–C(13) 110.7(3) C(7)–N(1)–O(1) 104.8(2)
    O(3)–C(13)–C(12) 109.8(3) C(11)–N(2)–C(12) 126.2(3)
    O(3)–C(14)–C(15) 116.2(3) C(11)–N(2)–C(14) 122.3(2)
    O(3)–C(14)–C(19) 123.9(3) C(12)–N(2)–C(14) 110.7(3)
    C(15)–C(14)–C(19) 119.9(3) C(9)–O(1)–N(1) 109.6(2)
    C(16)–C(15)–C(14) 121.0(4) C(13)–O(3)–C(14) 107.4(3)
    C(15)–C(16)–C(17) 120.5(3)
    下载: 导出CSV

    Table 2.  Hydrogen Bond Parameters in the Structures of 4a and 4b

    D–H···A d(D–H) d(H···A) d(D···A) ∠DHA
    4a C(11)–H(10A)···O(2)a 0.96 2.30 1.225(2) 169
    C(10)–H(10A)···F(1)b 0.96 2.60 1.386(3) 143
    4b C(3)–H(3)···O(2)c 0.93 2.70 3.463(21) 148
    C(12)–H(12B)···N(1)d 0.97 2.65 3.4080(48) 135
    Symmetry codes: (a) x–0.5, 1.5–x, –z; (b) 1–x, 0.5+y, 0.5–z; (c) 1–x, 2–y, 2–z; (d) 1–x, 1–y, 1–z
    下载: 导出CSV
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  • 发布日期:  2021-09-22
  • 收稿日期:  2021-02-22
  • 接受日期:  2021-04-14
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