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Synthesis, Crystal Structure and Antifungal Activity of 8-Chloro-3-((4-chlorobenzyl)-thio)[1,2,4]triazolo[4,3-a]pyridine

WANG Qiao ,  ZHAI Zhi-Wen ,  SUN Zhao-Hui ,  LIU Xing-Hai ,  TAN Cheng-Xia ,  WENG Jian-Quan

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Citation:  WANG Qiao, ZHAI Zhi-Wen, SUN Zhao-Hui, LIU Xing-Hai, TAN Cheng-Xia, WENG Jian-Quan. Synthesis, Crystal Structure and Antifungal Activity of 8-Chloro-3-((4-chlorobenzyl)-thio)[1,2,4]triazolo[4,3-a]pyridine[J]. Chinese Journal of Structural Chemistry, 2016, 35(4): 651-655. doi: 10.14102/j.cnki.0254-5861.2011-1022 shu

Synthesis, Crystal Structure and Antifungal Activity of 8-Chloro-3-((4-chlorobenzyl)-thio)[1,2,4]triazolo[4,3-a]pyridine

  • 1.

    College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China

  • 基金项目:

    This work was funded by the National Natural Science Foundation of China (No. 21002090) (No. 21002090)

    the Natural Science Foundation of Zhejiang Province (No. LY16C140007) (No. LY16C140007)

    Technology of Zhejiang Province (2014C31127, 2013C32SA700134) (2014C31127, 2013C32SA700134)

摘要: The title compound 8-chloro-3-((4-chlorobenzyl)thio)-[1,2,4]triazolo[4,3-a]pyridine was prepared from 1-chloro-4-(chloromethyl)benzene and 8-chloro-[1,2,4]triazolo[4,3-a]pyridine-3(2H)-thione in the presence of NaOH, and its structure was determined by X-ray diffraction analysis. The crystal is of triclinic system, space group P1 with a=6.8264(6), b=7.5890(4), c=13.0960(7) Å, α=93.447(4), β=98.772(6), γ=92.615(6)°, V=668.26(8) Å3, Z=2, the final R=0.035 and wR=0.09 for 2259 observed reflections with I > 2σ(I). The preliminary biological test showed that the title compound has activities against Stemphylium lycopersici (Enjoji) Yamamoto, Fusarium oxysporum. sp. cucumebrium, and Botrytis cinerea with inhibitory to be 51.19%, 62.02% and 15.56%, respectively.

English

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