Citation:
MENG Qing-Hua, LIU Qi-Feng, ZHANG Zun-Ting. Synthesis, Crystal Structure and Neuroprotection of a Novel Isoflavone Sulfonamide Compound[J]. Chinese Journal of Structural Chemistry,
2015, 34(9): 1446-1450.
doi:
10.14102/j.cnki.0254-5861.2011-0741
Synthesis, Crystal Structure and Neuroprotection of a Novel Isoflavone Sulfonamide Compound
摘要:
4',7-Dimethoxy-N-methylisoflavone-3'-sulfonamide (3) was synthesized by a two step synthesis method and characterized via IR and 1H NMR. Its chemical structure was determined by X-ray single-crystal diffraction. It crystallizes in monoclinic, space group C2/c with a=27.677(13), b=10.490(5) , c=13.982(7) Å, β=118.781(9)°, V=3558(3) Å3, Z=8, F(000)=1568, Dc=1.401 Mg/m3, Mr=375.39, μ=0.217 mm-1, λ=0.71073 Å, the final R=0.0436 and wR=0.0910 for 3168 observed reflections with I>2σ(I). The compound was studied subsequently for the potent neuroprotective activity, and showed effects against oxygen-glucose deprivation injury in PC12 cells in a dose-dependent manner (protection: 42.5% at 100 μg·mL−1, 35.1% at 10 μg·mL−1 and 22.5% at 1 μg·mL−1).
English
Synthesis, Crystal Structure and Neuroprotection of a Novel Isoflavone Sulfonamide Compound
Abstract:
4',7-Dimethoxy-N-methylisoflavone-3'-sulfonamide (3) was synthesized by a two step synthesis method and characterized via IR and 1H NMR. Its chemical structure was determined by X-ray single-crystal diffraction. It crystallizes in monoclinic, space group C2/c with a=27.677(13), b=10.490(5) , c=13.982(7) Å, β=118.781(9)°, V=3558(3) Å3, Z=8, F(000)=1568, Dc=1.401 Mg/m3, Mr=375.39, μ=0.217 mm-1, λ=0.71073 Å, the final R=0.0436 and wR=0.0910 for 3168 observed reflections with I>2σ(I). The compound was studied subsequently for the potent neuroprotective activity, and showed effects against oxygen-glucose deprivation injury in PC12 cells in a dose-dependent manner (protection: 42.5% at 100 μg·mL−1, 35.1% at 10 μg·mL−1 and 22.5% at 1 μg·mL−1).
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