经典Hofmann消除反应的机理探究

程宏宇 王瑞瑶 孙兴文

引用本文: 程宏宇, 王瑞瑶, 孙兴文. 经典Hofmann消除反应的机理探究[J]. 大学化学, 2025, 40(12): 187-191. doi: 10.12461/PKU.DXHX202510104 shu
Citation:  Hongyu Cheng,  Ruiyao Wang,  Xingwen Sun. Mechanistic Study of the Classic Hofmann Elimination Reaction[J]. University Chemistry, 2025, 40(12): 187-191. doi: 10.12461/PKU.DXHX202510104 shu

经典Hofmann消除反应的机理探究

    通讯作者: 孙兴文,E-mail:sunxingwen@fudan.edu.cn
  • 基金项目:

    复旦大学本科教学研究与改革实践项目(FD2022A102);上海市东方英才计划(教师项目)(JS2024005)

摘要: 对本科教学中涉及的开链季铵碱和环状季铵碱的消除机理进行了分析;对于环状季铵碱,当有两种反式共平面的β-H时,倾向于消除取代基较多的碳上的氢,得到扎伊采夫取向的烯烃为主要的产物,该结论也通过计算化学的手段得到佐证。该论文对Hofmann消除的本科教学是个丰富和支撑。

English

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  • 发布日期:  2025-12-05
  • 收稿日期:  2025-10-29
  • 修回日期:  2025-12-03
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