案例牵引，前沿融入，思维建立——化学生物学视角下的生命过程教学设计

引用本文: 何薇薇, 刘聪, 许代超, 王婧, 孙敏. 案例牵引，前沿融入，思维建立——化学生物学视角下的生命过程教学设计[J]. 大学化学, 2026, 41(6): 64-71. doi: 10.12461/PKU.DXHX202508048 shu

Citation: Weiwei He, Cong Liu, Daichao Xu, Jing Wang, Min Sun. Case-driven, frontier-integrated, and mindset-building: instructional design for life processes from a chemical biology perspective[J]. University Chemistry, 2026, 41(6): 64-71. doi: 10.12461/PKU.DXHX202508048 shu

案例牵引，前沿融入，思维建立——化学生物学视角下的生命过程教学设计

何薇薇 ^{1,
,} ,
刘聪 ^2, ,
许代超 ^2, ,
王婧 ^3, ,
孙敏 ^1,

1.
华东理工大学药学院, 生物反应器工程全国重点实验室, 上海市新药设计重点实验室, 上海 200237;
2.
中国科学院上海有机化学研究所, 生物与化学交叉研究中心, 上海 200032;
3.
中国科学院上海有机化学研究所, 生命过程小分子调控全国重点实验室, 上海 200032

通讯作者: 何薇薇,Email:heweiwei@ecust.edu.cn

基金项目:
国家自然科学基金(22477026)

摘要: 传统遗传学基于中心法则揭示了蛋白质功能的基本框架，但许多复杂的生命调控过程并不完全由基因序列决定，中心法则难以全面阐释其机制。化学生物学通过小分子直接结合并调控生物大分子功能，提供了解码生命过程的全新研究范式。本文以“101计划”《化学生物学》教材第14章“生命过程的化学调控”为例，设计了一种以“细胞膜-细胞质-细胞核”为主线，由外向内的空间层级的教学框架，通过典型案例，系统展示化学生物学如何以“现象→机制→转化”为逻辑链条解码复杂生命过程。通过案例分析与拓展讨论，学生不仅夯实了核心知识点，还能建立从靶点识别到机制解析、从功能调控到疾病干预的化学生物学思维。

关键词:

English

Case-driven, frontier-integrated, and mindset-building: instructional design for life processes from a chemical biology perspective

Weiwei He ^{1,
,} ,
Cong Liu ^2, ,
Daichao Xu ^2, ,
Jing Wang ^3, ,
Min Sun ^1,

1.
State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China;
2.
Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China;
3.
State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

Corresponding author: Weiwei He, heweiwei@ecust.edu.cn

Received Date: 15 August 2025
Revised Date: 09 October 2025
Available Online: 02 April 2026

Abstract: Traditional genetics, based on the central dogma, has established the fundamental framework of protein function. However, numerous complex regulatory processes in living systems cannot be fully explained by genetic sequences alone, as the central dogma has limitations in elucidating their underlying mechanisms. Chemical biology provides a transformative research paradigm by employing small molecules to directly interact with and modulate biomacromolecules, thereby decoding intricate life processes. Using Chapter 14 (“Chemical Regulation of Life Processes”) from the “101 Plan” Chemical Biology textbook as an example, this study proposes an instructional framework structured along a spatial hierarchy from the extracellular to intracellular level (“cell membrane → cytoplasm → nucleus”). Through representative case studies, the framework systematically demonstrates how chemical biology deciphers complex biological processes following the logical progression of “phenomenon → mechanism → translation”. Case analyses and extended discussions enable students to not only consolidate core knowledge but also develop chemical biology thinking that spans target identification, mechanistic investigation, functional modulation, and therapeutic intervention.

Key words:

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

案例牵引，前沿融入，思维建立——化学生物学视角下的生命过程教学设计

通讯作者: 何薇薇,Email:heweiwei@ecust.edu.cn

English

Case-driven, frontier-integrated, and mindset-building: instructional design for life processes from a chemical biology perspective

Corresponding author: Weiwei He, heweiwei@ecust.edu.cn

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

案例牵引，前沿融入，思维建立——化学生物学视角下的生命过程教学设计

通讯作者: 何薇薇,Email:heweiwei@ecust.edu.cn

English

Case-driven, frontier-integrated, and mindset-building: instructional design for life processes from a chemical biology perspective

Corresponding author: Weiwei He, heweiwei@ecust.edu.cn

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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