双环[1.1.0]丁烷合成策略的研究进展

卫柏同 朱荣秀 徐政虎

引用本文: 卫柏同, 朱荣秀, 徐政虎. 双环[1.1.0]丁烷合成策略的研究进展[J]. 大学化学, 2026, 41(9): 162-172. doi: 10.12461/PKU.DXHX202508027 shu
Citation:  Baitong Wei,  Rongxiu Zhu,  Zhenghu Xu. 双环[1.1.0]丁烷合成策略的研究进展[J]. University Chemistry, 2026, 41(9): 162-172. doi: 10.12461/PKU.DXHX202508027 shu

双环[1.1.0]丁烷合成策略的研究进展

    通讯作者: 朱荣秀,E-mail:rxzhu@sdu.edu.cn; 徐政虎,E-mail:xuzh@sdu.edu.cn
  • 基金项目:

    山东省自然科学基金(ZR2023MB072);山东大学教育教学改革研究项目(2023Y061,2024Z07)

摘要: 双环[1.1.0]丁烷(Bicyclo[1.1.0]butane,BCB)是碳原子最少的桥环化合物之一,具有高环张力和独特反应性,是一类构建功能化小分子的重要有机物,在药物化学、合成化学等领域引发广泛关注。本文系统梳理了BCBs的主要合成策略,按反应类型将其归纳为取代反应、插入反应和重排反应三大类,涵盖了从经典方法到最新研究的代表性案例。各类合成方法展现出构建路径的多样性与策略设计的创新性,有助于激发学生的学习兴趣与结构思维。本文旨在作为教材知识与前沿研究之间的桥梁,为有机合成课程教学与科研训练提供参考与拓展素材,并通过精选的典型案例,帮助课堂教学实现难点突破与思维训练。

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  • 发布日期:  2025-11-13
  • 收稿日期:  2025-08-05
  • 修回日期:  2025-09-30
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