融合吲哚单原子骨架编辑前沿的卡宾化学教学探索——化学“101计划”有机化学课程教学案例介绍

引用本文: 谭芬, 熊聪, 倪宇轩, 张之涵, 高轲, 肖文精, 陆良秋. 融合吲哚单原子骨架编辑前沿的卡宾化学教学探索——化学“101计划”有机化学课程教学案例介绍[J]. 大学化学, 2026, 41(6): 53-59. doi: 10.12461/PKU.DXHX202506066 shu

Citation: Fen Tan, Cong Xiong, Yu-Xuan Ni, Zhihan Zhang, Ke Gao, Wen-Jing Xiao, Liang-Qiu Lu. Carbene chemistry teaching integrated with cutting-edge single-atom skeletal editing of indoles: a case study in organic chemistry education under the “101 Plan”[J]. University Chemistry, 2026, 41(6): 53-59. doi: 10.12461/PKU.DXHX202506066 shu

融合吲哚单原子骨架编辑前沿的卡宾化学教学探索——化学“101计划”有机化学课程教学案例介绍

谭芬 ^1,2, ,
熊聪 ^1, ,
倪宇轩 ^1, ,
张之涵 ^1, ,
高轲 ^1, ,
肖文精 ^1, ,
陆良秋 ^{1,
,}

1.
华中师范大学化学学院, 湖北武汉 430079;
2.
湖北第二师范学院化学与生命科学学院, 湖北武汉 430205

通讯作者: 陆良秋,Email:luliangqiu@ccnu.edu.cn

基金项目:
国家重点研发计划(2023YFA1507203)；中央高校基本科研业务费(30106190336)

摘要: 面向化学“101计划”拔尖人才培养目标，本研究以卡宾中间体为核心纽带，将单原子骨架编辑前沿成果深度融入有机化学教学。通过“理论学习-文献解析-创新设计”三阶模式，引导学生运用卡宾的基础知识解析吲哚分子单原子骨架编辑的机制。本案例为“基础知识-前沿研究”融合式教学提供可复制范式，助力有机化学课程改革。

关键词:

English

Carbene chemistry teaching integrated with cutting-edge single-atom skeletal editing of indoles: a case study in organic chemistry education under the “101 Plan”

1.
College of Chemistry, Central China Normal University, Wuhan 430079, Hubei Province, China;
2.
School of Chemistry and Life Sciences, Hubei University of Education, Wuhan 430205, Hubei Province, China

Corresponding author: Liang-Qiu Lu, luliangqiu@ccnu.edu.cn

Received Date: 15 June 2025
Revised Date: 29 August 2025
Available Online: 17 March 2026

Abstract: Aligned with the talent development objectives of the Chemistry “101 Plan”, this study employs carbene intermediates as a conceptual bridge to incorporate advanced single-atom skeletal editing research into organic chemistry pedagogy. Through a three-phase instructional model encompassing “theoretical fundamentals, literature analysis, and innovative design”, students are guided to apply foundational carbene chemistry principles to examine the mechanisms of single-atom skeletal editing in indole molecules. This teaching paradigm demonstrates a replicable approach for integrating core knowledge with frontier research, contributing to the ongoing reform of organic chemistry curricula.

Key words:

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融合吲哚单原子骨架编辑前沿的卡宾化学教学探索——化学“101计划”有机化学课程教学案例介绍

通讯作者: 陆良秋,Email:luliangqiu@ccnu.edu.cn

English

Carbene chemistry teaching integrated with cutting-edge single-atom skeletal editing of indoles: a case study in organic chemistry education under the “101 Plan”

Corresponding author: Liang-Qiu Lu, luliangqiu@ccnu.edu.cn

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

融合吲哚单原子骨架编辑前沿的卡宾化学教学探索——化学“101计划”有机化学课程教学案例介绍

通讯作者: 陆良秋,Email:luliangqiu@ccnu.edu.cn

English

Carbene chemistry teaching integrated with cutting-edge single-atom skeletal editing of indoles: a case study in organic chemistry education under the “101 Plan”

Corresponding author: Liang-Qiu Lu, luliangqiu@ccnu.edu.cn

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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