自动化与AI辅助探究磺基水杨酸的化学反应性

引用本文: 张婧轩, 姜玮豪, 张思远, 田宏业, 黄子烨, 黄林, 吴奇坤, 杨静, 蒋一彬, 汪骋. 自动化与AI辅助探究磺基水杨酸的化学反应性[J]. 大学化学, 2026, 41(1): 332-345. doi: 10.12461/PKU.DXHX202505108 shu

Citation: Jingxuan Zhang, Weihao Jiang, Siyuan Zhang, Hongye Tian, Ziye Huang, Lin Huang, Qikun Wu, Jing Yang, Yibin Jiang, Cheng Wang. Automation and AI-Assisted Investigation of the Chemical Reactivity of Sulfosalicylic Acid[J]. University Chemistry, 2026, 41(1): 332-345. doi: 10.12461/PKU.DXHX202505108 shu

自动化与AI辅助探究磺基水杨酸的化学反应性

厦门大学化学化工学院, 福建厦门 361005

通讯作者: 杨静，E-mail:j.yang@xmu.edu.cn; 汪骋，E-mail:wangchengxmu@xmu.edu.cn

基金项目:
央属高校业务科研费(20720250005)；2024 年福建省高等教育学会高等教育科学研究实验室研究专项课题(24FJSYZD003)；中外化学教育考试比较研究(FJJKKS24-07)

摘要: 随着自动化与人工智能(AI)技术在科研领域的持续迭代，化学实验教学亟需革新以适配现代化学研究范式，助力学生掌握前沿工具与方法。本实验创新性融入自动化设备与基于检索增强生成(RAG)技术构建的AI助教，既展现了化学研究的智能化发展趋势，又实现了学生数据分析能力与实验操作效率的双重提升。实验以磺基水杨酸(HO₃SC₆H₃(OH) CO₂H，用H₃R表示)为核心研究对象，聚焦两大核心目标：一是测定其二级、三级电离平衡常数(pK_a₂和pK_a₃)，二是探究其与铜离子形成配合物的组成及稳定常数。实验过程中，自动化滴定设备与pH计协同工作，精准监测滴定全程pH变化并绘制曲线，同时结合紫外-可见(UV-Vis)光谱完成表征；AI助教支持语音交互答疑，且配套的AI工具可辅助学生快速处理实验数据、精准计算电离平衡常数。针对配合物研究，实验采用等摩尔连续变化法，通过自动化平台精准配制系列比例反应溶液，系统探究配合物的组成规律及稳定性。该实验设计既确保学生扎实掌握酸碱滴定、电离平衡、配位化学等核心知识，又通过沉浸式接触自动化与AI技术，有效培养学生的创新思维与智能技术应用能力，实现了知识传授与能力培养的有机统一。

关键词:

English

Automation and AI-Assisted Investigation of the Chemical Reactivity of Sulfosalicylic Acid

College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian Province, China

Corresponding author: Jing Yang, ; Cheng Wang,

Received Date: 30 May 2025
Revised Date: 09 September 2025
Available Online: 20 November 2025

Abstract: With the growing penetration of automation and artificial intelligence (AI) technologies in scientific research, chemical laboratory education, must keep pace with the times by integrating cutting-edge technologies, enabling students to familiarize themselves with advanced tools and methodologies in modern chemical research. This experiment integrates automated equipment and an AI teaching assistant built on Retrieval-Augmented Generation (RAG) technology, showcasing the intelligent transformation trends of future chemical research while achieving a dual enhancement of students’ data analysis capabilities and experimental efficiency. Focusing on the chemical reactivity of sulfosalicylic acid (HO₃SC₆H₃(OH)CO₂H, H₃R), the study centers on two core objectives. First, determining its second and third ionization equilibrium constants (pK_a₂ and pK_a₃); second, investigating the composition and stability constants of its copper(II) complexes. Automated titration equipment works in synergy with pH meters to accurately monitor pH changes throughout the titration process for curve plotting, while ultraviolet-visible (UV-Vis) spectroscopy provides complementary characterization. The AI teaching assistant supports voice-interactive Q&A to address students’ queries, and the supporting AI tools facilitate rapid experimental data processing and accurate calculation of ionization equilibrium constants. For the investigation of complexes, the experiment adopts the method of continuous variations with equimolar ratios. A series of reaction solutions with varying molar ratios are precisely prepared via an automated platform, enabling systematic exploration of the compositional rules and stability of the complexes formed by H₃R and Cu(II). This approach not only ensures students solidly grasp core chemical knowledge, but also effectively cultivates their innovative thinking and intelligent technology application capabilities through immersive exposure to automation and AI systems, realizing the organic integration of knowledge imparting and capability development.

Key words:

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沈阳化工大学材料科学与工程学院沈阳 110142

自动化与AI辅助探究磺基水杨酸的化学反应性

通讯作者: 杨静，E-mail:j.yang@xmu.edu.cn; 汪骋，E-mail:wangchengxmu@xmu.edu.cn

English

Automation and AI-Assisted Investigation of the Chemical Reactivity of Sulfosalicylic Acid

Corresponding author: Jing Yang, ; Cheng Wang,

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

自动化与AI辅助探究磺基水杨酸的化学反应性

通讯作者: 杨静，E-mail:j.yang@xmu.edu.cn; 汪骋，E-mail:wangchengxmu@xmu.edu.cn

English

Automation and AI-Assisted Investigation of the Chemical Reactivity of Sulfosalicylic Acid

Corresponding author: Jing Yang, ; Cheng Wang,

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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通讯作者: 陈斌, bchen63@163.com

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