Abstract: The contents of Chemical Reaction Engineering courses are characterized by strong logicality, a high degree of specialization, and abstract theoretical knowledge, which presents certain challenges when integrating with ideological and political elements that cover philosophy, politics, society, and ethics. Based on the principles of OBE (Outcome-Based Education) and engineering education, as well as the requirements for first-class undergraduate curriculum construction, the teaching team deeply explores the ideological and political elements embedded in the curriculum during the process of knowledge impartation. The stories of great scientists' hard work and self-reliance in science and technology, along with the engineering case analysis and practice in real production lines, combining with the study and sharing of cutting-edge scientific literature, are incorporated into the entire process of education and teaching. This approach explores a new path of learning-thinking-practicing-reflecting to integrate ideological and political education into the curriculum. The ideological and political teaching goal can be subtly achieved, as well as the effectiveness of curriculum-based education of the course is simultaneously enhanced. The results show that the ideological and political teaching goal has increased, and the reform and practice effectively stimulate students' professional learning interests and foster their sense of mission to engage in the chemistry and chemical engineering industry in the Bay Area.