基础与前沿有机结合在有机合成教学中的应用—

引用本文: 马登科. 基础与前沿有机结合在有机合成教学中的应用——以不对称Meinwald重排反应为例[J]. 大学化学, 2026, 41(4): 67-74. doi: 10.12461/PKU.DXHX202502112 shu

Citation: Dengke Ma. Application of Integrating Fundamental Knowledge and Cutting-Edge Developments in the Teaching of Organic Synthesis: Taking the Asymmetric Meinwald Rearrangement as an Example[J]. University Chemistry, 2026, 41(4): 67-74. doi: 10.12461/PKU.DXHX202502112 shu

基础与前沿有机结合在有机合成教学中的应用——以不对称Meinwald重排反应为例

马登科 ^,

首都医科大学药学院, 北京 100069

通讯作者: 马登科,E-mail:madk@ccmu.edu.cn

基金项目:
国家自然科学基金(22201187)

摘要: 有机合成课程是高校化学相关专业的一门重要的专业基础课，具有很强的实用性。然而有机合成课程知识点、反应繁多，学生理解、记忆和应用通常面临困难。为了解决这一问题，本文设计了一种基础与前沿相结合的教学模式，具体以不对称Meinwald重排反应为例，通过该重排反应的介绍、发展、机理与不对称转化，以及在天然产物合成中的应用讲述，有机地将课本上讲述的一些基础知识和概念，以及氧化还原反应、重排反应等部分的内容串联起来，帮助学生理清知识脉络，对于所学内容有了更为具体和深刻的认识，强化了理解和记忆。同时融入课程思政，培养学生的科研兴趣和探索精神，包括实验室安全和环境保护意识等，为培养具有坚定政治信念、高尚思想品德和扎实专业能力的高素质人才贡献力量。

关键词:

English

Application of Integrating Fundamental Knowledge and Cutting-Edge Developments in the Teaching of Organic Synthesis: Taking the Asymmetric Meinwald Rearrangement as an Example

Dengke Ma ^,

School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China

Corresponding author: Dengke Ma, madk@ccmu.edu.cn

Received Date: 24 February 2025
Accepted Date: 07 April 2025
Available Online: 31 July 2025

Abstract: Organic synthesis serves as a pivotal foundational course for chemistry-related disciplines in higher education, characterized by its strong practical orientation. However, students frequently encounter challenges in comprehending, retaining, and applying the extensive array of knowledge points and reactions inherent in this subject. To address these pedagogical difficulties, this study proposes an innovative teaching model that effectively integrates fundamental principles with cutting-edge developments, using the asymmetric Meinwald rearrangement as a representative case. Through systematic exploration of this reaction's historical development, mechanistic insights, asymmetric transformations, and applications in natural product synthesis, the model establishes meaningful connections within textbook-based fundamental concepts and key reaction types, including oxidation-reduction and rearrangement processes. This integrative approach facilitates students' comprehension of knowledge frameworks, enabling them to develop more concrete and profound understanding of the subject matter, thereby enhancing both conceptual grasp and retention. Furthermore, the incorporation of ideological and political education elements fosters students' scientific curiosity and spirit of exploration, while simultaneously cultivating essential awareness of laboratory safety and environmental protection. This comprehensive pedagogical strategy contributes significantly to the development of high-caliber professionals equipped with steadfast political convictions, exemplary moral character, and robust professional competencies.

Key words:

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沈阳化工大学材料科学与工程学院沈阳 110142

基础与前沿有机结合在有机合成教学中的应用——以不对称Meinwald重排反应为例

通讯作者: 马登科,E-mail:madk@ccmu.edu.cn

English

Application of Integrating Fundamental Knowledge and Cutting-Edge Developments in the Teaching of Organic Synthesis: Taking the Asymmetric Meinwald Rearrangement as an Example

Corresponding author: Dengke Ma, madk@ccmu.edu.cn

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

基础与前沿有机结合在有机合成教学中的应用——以不对称Meinwald重排反应为例

通讯作者: 马登科,E-mail:madk@ccmu.edu.cn

English

Application of Integrating Fundamental Knowledge and Cutting-Edge Developments in the Teaching of Organic Synthesis: Taking the Asymmetric Meinwald Rearrangement as an Example

Corresponding author: Dengke Ma, madk@ccmu.edu.cn

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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通讯作者: 陈斌, bchen63@163.com

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