纳米金辅助介质阻挡放电离子化质谱分析法在兽药饲料快检中的应用

引用本文: 赵鹏, 刘云, 洪欢欢, 闻路红, 史振志, 张新荣, 张四纯, 李学军. 纳米金辅助介质阻挡放电离子化质谱分析法在兽药饲料快检中的应用[J]. 分析化学, 2018, 46(7): 1089-1094. doi: 10.11895/j.issn.0253-3820.181099 shu

Citation: ZHAO Peng, LIU Yun, HONG Huan-Huan, WEN Lu-Hong, SHI Zhen-Zhi, ZHANG Xin-Rong, ZHANG Si-Chun, LI Xue-Jun. Fast Analysis of Veterinary Drugs in Feed Using Gold Nanoparticles-assisted Dielectric Barrier Discharge Ion Source-Mass Spectrometry[J]. Chinese Journal of Analytical Chemistry, 2018, 46(7): 1089-1094. doi: 10.11895/j.issn.0253-3820.181099 shu

纳米金辅助介质阻挡放电离子化质谱分析法在兽药饲料快检中的应用

赵鹏 ^1, ,
刘云 ^1, ,
洪欢欢 ^1, ,
闻路红 ^1, ,
史振志 ^1, ,
张新荣 ^2, ,
张四纯 ^2, ,
李学军 ^3,

1.
宁波大学高等技术研究院, 宁波 315000;
2.
清华大学化学系, 北京 100084;
3.
营口出入境检验检疫局, 营口 115004
基金项目:
本文系国家重大科学仪器设备开发专项项目（No.2016YFF0100300）、国家自然科学基金项目（No.51605231），宁波市自然科学基金项目（No.2016A610055）、宁波市科技局/自然科学基金项目（No.2017A610164）和宁波大学王宽诚幸福基金项目资助

摘要: 介质阻挡放电离子化质谱分析法具有无需复杂样品前处理、分析速度快等优点，可实现样品原位、高效检测，成为质谱分析领域的热点技术。本研究提出了一种基于纳米金辅助纸基进样方式的介质阻挡放电离子源-质谱（DBDI-MS）联用技术，实现了氟甲喹、二甲氧苄啶、替硝唑、地美硝唑共4种兽药的快速检测。结果表明，在氦气流量为2.5 L/min、离子源温度为200℃等最优实验条件下，4种兽药检测信号强度均比无纳米金辅助时提高了8~31倍。4种兽药样品在各自的浓度范围内有较好的线性关系，相关系数（r）为0.952~0.996，且在饲料基质中的加标回收率为79.4%~96.5%。本方法能快速检测兽药饲料，具有灵敏度高、检测费用低、实用性好等优点，所得结果基本满足农业部限定标准要求，适合现场检测，在饲料质量控制方面具有较好的应用前景。

关键词:

English

Fast Analysis of Veterinary Drugs in Feed Using Gold Nanoparticles-assisted Dielectric Barrier Discharge Ion Source-Mass Spectrometry

1.
The Research Institute of Advanced Technologies, Ningbo University, Ningbo 315211, China;
2.
Department of Chemistry, Tsinghua University, Beijing 100084, China;
3.
Yingkou Entry-Exit Inspection and Quarantine Bureau, Yingkou 115004, China
Received Date: 05 February 2018
Revised Date: 16 May 2018
Fund Project:
This work was supported by the National Key Scientific Instrument and Equipment Development Project (No. 2016YFF0100300), the National Natural Science Foundation of China (No.51605231), the Ningbo Municipal Natural Science Foundation (No. 2016A610055), the Ningbo Municipal Natural Science Foundation (No. 2017A610164) and the K.C. Wong Magna Fund in Ningbo University, China.

Abstract: Dielectric barrier discharge ion source-mass spectrometry (DBDI-MS) can achieve in-situ and efficient detection of samples without tedious pretreatment, and has become a popular analytical method. To improve the detection sensitivity, a novel mass spectrometric method based on gold nanoparticles (AuNPs)-assisted paper-based injection mode and DBDI-MS technology was developed for the fast determination of four veterinary drugs. The detection signal strength was improved by 8-31 times compared to the veterinary drugs which were tested without AuNPs-assisted paper based injection. Under the optimal conditions, the experimental data of four veterinary drugs showed a good linear relationship between the signal and the concentration in the respective range, with correlation coefficient (r) of 0.951-0.996. Moreover, the recoveries were between 79.4% and 96.5% at three spiked levels. This method has many distinct advantages, such as low detected limitation, low cost and high efficiency, and is also very suitable for fast on-site detecting, showing great potential in feed quality control.

Key words:

Dielectric barrier discharge ion source-mass spectrometry
/ Paper-based injection
/ Gold nanoparticles
/ Veterinary drug

1. [1]
  ZHAO Chun-Bao, PENG Da-Peng, TAO Yan-Fei, CHEN Dong-Mei, YUAN Zong-Hui. Journal of Agricultural Science and Technology, 2008, 10(S2):69-75 赵春保, 彭大鹏, 陶燕飞, 陈冬梅, 袁宗辉. 中国农业科技导报, 2008, 10(S2):69-75
2. [2]
  YANG Bing-Yi, ZHAI Hai-Yun, CHEN Gui-Xian, LUO Na, MO Jin-Yuan. Journal of Analytical Science, 2009, 25(6):657-660 杨冰仪, 翟海云, 陈桂贤, 罗娜, 莫金垣. 分析科学学报, 2009, 25(6):657-660
3. [3]
  CHENG Lin-Li, ZHANG Su-Xia, SHEN Jian-Zhong, WANG Zhan-Hui, LI Yan-Shen, FENG Pei-Sheng. Chinese J. Anal. Chem., 2009, 37(5):718-720 程林丽, 张素霞, 沈建忠, 王战辉, 李彦伸, 冯培生. 分析化学, 2009, 37(5):718-720
4. [4]
  LIN Xiao-Li, LI Ning, HUO Feng, DONG Yan-Feng, PENG Wei. Journal of Instrumental Analysis, 2016, 35(3):322-326 林小莉, 李宁, 霍峰, 董艳峰, 彭玮. 分析测试学报, 2016, 35(3):322-326
5. [5]
  SUO De-Cheng, ZHAO Gen-Long, LI Lan, SU Xiao-Ou. Chinese J. Anal. Chem., 2010, 38(7):1023-1026 索德成, 赵根龙, 李兰, 苏晓鸥. 分析化学, 2010, 38(7):1023-1026
6. [6]
  NING Lu-Sheng, XU Ming, GUO Cheng-An, ZHAO Peng, WEN Lu-Hong, ZHANG Xin-Rong. Chinese J. Anal. Chem., 2016, 44(2):252-257 宁录胜, 徐明, 郭成安, 赵鹏, 闻路红, 张新荣. 分析化学, 2016, 44(2):252-257
7. [7]
  Na N, Zhang C, Zhao M, Zhang S, Yang C, Fang X. J. Mass Spectrom., 2007, 42(8):1079-1085
8. [8]
  Na N, Zhao M, Zhang S, Yang C, Zhang X. J. Mass Spectrom., 2007, 18(10):1859-1862
9. [9]
  Gong X, Xiong X, Peng Y, Yang C, Zhang S, Fang X. Talanta, 2011, 85(5):2458-2462
10. [10]
  Huang G, Xu W, Visbal-Onufrak M A, Ouyang Z, Cooks R G. Analyst, 2010, 135(4):705
11. [11]
  HONG Huan-Huan, ZHAO Peng, NING Lu-Sheng, WEN Lu-Hong, XU Tie-Feng. Chinese J. Anal. Chem., 2017, 45(10):1529-1534 洪欢欢, 赵鹏, 宁录胜, 闻路红, 徐铁峰. 分析化学, 2017, 45(10):1529-1534
12. [12]
  Glavan A C, Christodouleas D C, Mosadegh B, Yu H D, Smith B S, Lessing J. Anal. Chem., 2014, 86(24):11999-12007
13. [13]
  Martinez A W, Phillips S T, Whitesides G M, Carrilho E, Chem A. Anal. Chem., 2010, 82(1):3-10
14. [14]
  Scida K, Cunningham JC, Renault C, Richards I, Crooks R M. Anal. Chem., 2014, 86(13):6501-6507
15. [15]
  Li X,Ballerini D R, Shen W. Biomicrofluidics, 2012, 6(1):011301-13
16. [16]
  Liu H, Crooks R M. J. Am. Chem. Soc., 2011, 133(44):17564-17566
17. [17]
  Kim J Y, Yeo M K. Mol. Cell. Toxicol., 2016, 12(1):101-109
18. [18]
  Bai Y, Feng F, Zhao L, Wang C, Wang H, Tian M. Biosens. Bioelectron., 2013, 47(47C):265-270
19. [19]
  WANG Hong-Ya, YIN Bin-Cheng, YE Bang-Ce. Chinese J. Anal. Chem., 2017, 45 (12):2018-2025 王红亚, 尹斌成, 叶邦策. 分析化学, 2017, 45 (12):2018-2025
20. [20]
  Darbha G K, Ray A, Ray P C. ACS Nano, 2007, 1(3):208-214
21. [21]
  Yun C S, Javier A, Jennings T. J. Am. Chem. Soc., 2005, 127(9):3115-3119
22. [22]
  Gao M X, Zou H Y, Li Y F. Anal. Chem., 2017, 89(3):1808-1814
23. [23]
  Cody R B, Laramee J A, Nilles J M, Durst H D. Anal. Chem., 2005, 77(8):2297-2302
24. [24]
  Ministey of Agriculture. No. 2349, Determination of Sulfonamides and Quinolones in Feeds-Liquid Chromatography Tandem Mass Spectrometry. Bulletion of Ministry of Agriculture of the People's Republic of China 饲料中磺胺类和喹诺酮类药物的测定液相色谱-串联质谱法. 中华人民共和国国家标准. 农业部2349号公告-5-2015和-6-2015

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沈阳化工大学材料科学与工程学院沈阳 110142

纳米金辅助介质阻挡放电离子化质谱分析法在兽药饲料快检中的应用

English

Fast Analysis of Veterinary Drugs in Feed Using Gold Nanoparticles-assisted Dielectric Barrier Discharge Ion Source-Mass Spectrometry

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中国化学会秘书处

纳米金辅助介质阻挡放电离子化质谱分析法在兽药饲料快检中的应用

English

Fast Analysis of Veterinary Drugs in Feed Using Gold Nanoparticles-assisted Dielectric Barrier Discharge Ion Source-Mass Spectrometry

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

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CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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