Gd2(CO3)3:Eu@SiO2@APTES磁性-荧光双功能核壳微球的制备与性能

引用本文: 吴燕利, 徐贤柱, 文佳, 肖强, 李永绣. Gd₂(CO₃)₃:Eu@SiO₂@APTES磁性-荧光双功能核壳微球的制备与性能[J]. 无机化学学报, 2015, (6): 1125-1130. doi: 10.11862/CJIC.2015.154 shu

Citation: WU Yan-Li, XU Xian-Zhu, WEN Jia, XIAO Qiang, LI Yong-Xiu. Synthesis and Properties of Paramagnetic-Fluorescent Gd₂(CO₃)₃:Eu@SiO₂@APTES Core-Shell Structured Microspheres[J]. Chinese Journal of Inorganic Chemistry, 2015, (6): 1125-1130. doi: 10.11862/CJIC.2015.154 shu

Gd₂(CO₃)₃:Eu@SiO₂@APTES磁性-荧光双功能核壳微球的制备与性能

吴燕利 ^1, ,
徐贤柱 ^2, ,
文佳 ^1, ,
肖强 ^1, ,
李永绣 ^{3,
,}

1.
1 江西科技师范大学有机功能分子研究所, 南昌 330013;
2.
2 江西师范大学生命学院, 南昌 330022;
3.
3 南昌大学化学学院, 南昌 330031

通讯作者: 肖强 wanny118@126.com,李永绣 yxli@ncu.edu.cn

基金项目:
江西省教育厅一般项目(No.GJJ14578,GJJ13216) (No.GJJ14578,GJJ13216)

江西省科技支撑项目(No.20142BBF60008)资助。 (No.20142BBF60008)

摘要: 采用尿素均相沉淀法和Stöber法制备了氨基化SiO₂修饰的Gd₂(CO₃)₃:Eu顺磁性-荧光双功能微球。用扫描电镜(SEM)、红外光谱(IR)、X-射线粉末衍射(XRD)等测试手段对微球的结构和颗粒特征进行了分析。结果表明:微球为核壳结构,其Gd₂(CO₃)₃:Eu核平均直径为150nm左右,SiO₂壳层的厚度大约为30nm,分散性良好。磁性测试显示微球拥有良好的顺磁性,荧光光谱表明,在396nm紫外光激发下,微球在613nm发射较强荧光,属于Eu³⁺的特征发射,同时微球能成功标记NCIH460肺癌细胞,MTT毒性测试表明该法制备的双功能微球在100~400μg·mL^-1的浓度范围内无毒,表明其在生物应用方面的潜在应用价值。

关键词:

顺磁性;荧光;双功能微球;核壳结构;尿素均相沉淀法

English

Synthesis and Properties of Paramagnetic-Fluorescent Gd₂(CO₃)₃:Eu@SiO₂@APTES Core-Shell Structured Microspheres

1.
1 Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang 330013, China;
2.
2 College of Life Science, Jiangxi Normal University, Nanchang 330022, China;
3.
3 College of Chemistry, Nanchang Universtiy, Nanchang 330031, China

Corresponding author: 肖强 wanny118@126.com,李永绣 yxli@ncu.edu.cn

Received Date: 03 December 2014
Fund Project:
江西省教育厅一般项目(No.GJJ14578,GJJ13216)

江西省科技支撑项目(No.20142BBF60008)资助。

Abstract: Monodisperse core-shell structured Gd₂(CO₃)₃:Eu@SiO₂@APTES microsphere was successfully prepared via the stöber method by coating a layer of silica on the surface of Gd₂(CO₃)₃:Eu microspheres which derived from a simple urea assisted coprecipitation method. Their structural, optical and magnetic properties were investigated using SEM, TEM, XRD, FTIR, PL, and MPMS. The results indicated that the microspheres with general 30 nm shell thickness and 150 nm core size has spherical morphology with smooth surface and narrow size distribution. The paramagnetic property of the synthesized Gd₂(CO₃)₃:Eu@SiO₂@APTES microspheres were confirmed with its linear hysteresis plot (M-H). The synthesized microspheres can enter into living cancer cells and emit orange-red luminescence light due to the ⁵D₀→⁷F₂ transition of the Eu³⁺ ions, and Gd₂(CO₃)₃:Eu@SiO₂@APTES microspheres showed no cell cytotoxicity or adverse affect on kidney cell growth under high dose up to 400 μg·mL^-1. Therefore, Gd₂(CO₃)₃:Eu@SiO₂@APTES microspheres provides the dual modality of optical and magnetic resonance imaging.

Key words:

paramagnetic;fluorescent;bifunctional microsphere;core-shell structure;urea assisted coprecipitation method

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Gd₂(CO₃)₃:Eu@SiO₂@APTES磁性-荧光双功能核壳微球的制备与性能

通讯作者: 肖强 wanny118@126.com,李永绣 yxli@ncu.edu.cn

English

Synthesis and Properties of Paramagnetic-Fluorescent Gd₂(CO₃)₃:Eu@SiO₂@APTES Core-Shell Structured Microspheres

Corresponding author: 肖强 wanny118@126.com,李永绣 yxli@ncu.edu.cn

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