引用本文:
Xueting Hu, Lijia Zhao, Tingting Liao, Cheng-Peng Li. Crystalline porous organic frameworks: Emerging platforms for enzyme immobilization in biomedical applications[J]. Chinese Journal of Structural Chemistry,
2026, 45(2): 100793.
doi:
10.1016/j.cjsc.2025.100793
Citation: Xueting Hu, Lijia Zhao, Tingting Liao, Cheng-Peng Li. Crystalline porous organic frameworks: Emerging platforms for enzyme immobilization in biomedical applications[J]. Chinese Journal of Structural Chemistry, 2026, 45(2): 100793. doi: 10.1016/j.cjsc.2025.100793
Citation: Xueting Hu, Lijia Zhao, Tingting Liao, Cheng-Peng Li. Crystalline porous organic frameworks: Emerging platforms for enzyme immobilization in biomedical applications[J]. Chinese Journal of Structural Chemistry, 2026, 45(2): 100793. doi: 10.1016/j.cjsc.2025.100793
Crystalline porous organic frameworks: Emerging platforms for enzyme immobilization in biomedical applications
摘要:
Crystalline porous organic frameworks (CPOFs), with their highly ordered pores and tunable organic structures, have shown immense promise as platforms for enzyme immobilization. However, research on enzyme@CPOF composites, particularly for biomedical applications, is still in its early stages and lacks comprehensive and systematic review. This article provides a thorough overview of recent advances in the rational design, synthesis, and application of enzyme@CPOF biocomposites. Emphasis is placed on immobilization strategies and the structure-performance relationships revealed through molecular-level investigations. Furthermore, we highlight emerging applications in biocatalysis and biomedical engineering, and discuss persistent challenges and future directions to advance CPOFs as versatile, high-performance substrates for enzyme immobilization.
English
Crystalline porous organic frameworks: Emerging platforms for enzyme immobilization in biomedical applications
Abstract:
Crystalline porous organic frameworks (CPOFs), with their highly ordered pores and tunable organic structures, have shown immense promise as platforms for enzyme immobilization. However, research on enzyme@CPOF composites, particularly for biomedical applications, is still in its early stages and lacks comprehensive and systematic review. This article provides a thorough overview of recent advances in the rational design, synthesis, and application of enzyme@CPOF biocomposites. Emphasis is placed on immobilization strategies and the structure-performance relationships revealed through molecular-level investigations. Furthermore, we highlight emerging applications in biocatalysis and biomedical engineering, and discuss persistent challenges and future directions to advance CPOFs as versatile, high-performance substrates for enzyme immobilization.
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