Research progress on piperidine-containing compounds as agrochemicals

Citation: Wei Sun, Anjing Liao, Li Lei, Xu Tang, Ya Wang, Jian Wu. Research progress on piperidine-containing compounds as agrochemicals[J]. Chinese Chemical Letters, 2025, 36(1): 109855. doi: 10.1016/j.cclet.2024.109855 shu

Research progress on piperidine-containing compounds as agrochemicals

English

Research progress on piperidine-containing compounds as agrochemicals

State Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China
^* Corresponding author.
E-mail address: jwu6@gzu.edu.cn (J. Wu).
Received Date: 09 January 2024
Accepted Date: 02 April 2024
Revised Date: 26 March 2024
Available Online: 15 January 2025

Abstract: Piperidine is a crucial pharmacophore and a special scaffold in the realm of drug discovery. Its flexibility increases the molecule's capability to bind to the receptor. The piperidine-containing compounds are distinguished by their remarkable activity, and are increasingly becoming a vital category of pesticides. In this review, the research progress of piperidines in the discovery of pesticides was updated according to their active characteristics. The structure-activity relationships (SARs), and mechanisms of action of piperidine-containing compounds were also discussed. This article is meant to enable readers to quickly understand piperidines, while providing ideas for creating piperidines with novel structures and unique mechanisms of action.

Key words:

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Figure 1 Structures of piperidine-containing commercial drugs.

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Figure 2 (A) Thiazolylpiperidine compounds (1–14) with antifungal (antibacterial) activity. (B) The binding modes of oxathiapiprolin and compound 14 to pcOSBP. This panel was reproduced with permission [70]. Copyright 2019, Elsevier.

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Figure 3 Thiazolylpiperidine compounds (15–32) with antifungal (antibacterial) activity.

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Figure 4 Piperidine compounds (46–62) with insecticidal activity.

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Figure 5 Piperidine compounds (63–72) with insecticidal activity.

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Figure 6 Piperidine compounds (73–85) with insecticidal activity.

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Figure 7 Piperidine compounds (86–92) with herbicidal activity.

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Figure 8 Piperidine compounds (93–96) with plant growth regulating activity and antiviral activity.

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