Camphor-derived thioureas: Synthesis and application in asymmetric Kabachnik-Fields reaction

Pogula Sreekanth Reddy Motakatla Venkata Krishna Reddy Peddiahgari Vasu Govardhana Reddy

引用本文: Pogula Sreekanth Reddy,  Motakatla Venkata Krishna Reddy,  Peddiahgari Vasu Govardhana Reddy. Camphor-derived thioureas: Synthesis and application in asymmetric Kabachnik-Fields reaction[J]. Chinese Chemical Letters, 2016, 27(6): 943-947. doi: 10.1016/j.cclet.2016.01.046 shu
Citation:  Pogula Sreekanth Reddy,  Motakatla Venkata Krishna Reddy,  Peddiahgari Vasu Govardhana Reddy. Camphor-derived thioureas: Synthesis and application in asymmetric Kabachnik-Fields reaction[J]. Chinese Chemical Letters, 2016, 27(6): 943-947. doi: 10.1016/j.cclet.2016.01.046 shu

Camphor-derived thioureas: Synthesis and application in asymmetric Kabachnik-Fields reaction

  • 基金项目:

    This project was supported by the Department of Science and Technology (DST), New Delhi, India (No. SR/FT/CS-013/2010) and is gratefully acknowledged.

摘要: A series of camphor-derived thiourea organocatalysts 3a-f were designed and synthesized from (1R,3S)-camphoric acid 1 and applied to the one-pot three-component Kabachnik-Fields reaction. Catalyst 3c was found to be an efficient organocatalyst for the reaction of 2-cyclopropylpyrimidin-4-carbaldehyde 4, various amines 5, and diphenylphosphite 6 to yield the corresponding enantioselective a-aminophosphonates 7a-e in 74%-82% yields and 14%-35% ee.

English

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  • 收稿日期:  2015-11-02
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