引用本文:
Wei Huang, Ming Lv, Zhong Gao Gao. Synthesis of polyethylenimine grafted with copolymers of polyethylene glycol and polycaprolactone and its potential for siRNA delivery[J]. Chinese Chemical Letters,
2011, 22(6): 749-752.
doi:
10.1016/j.cclet.2010.12.057
Citation: Wei Huang, Ming Lv, Zhong Gao Gao. Synthesis of polyethylenimine grafted with copolymers of polyethylene glycol and polycaprolactone and its potential for siRNA delivery[J]. Chinese Chemical Letters, 2011, 22(6): 749-752. doi: 10.1016/j.cclet.2010.12.057
Citation: Wei Huang, Ming Lv, Zhong Gao Gao. Synthesis of polyethylenimine grafted with copolymers of polyethylene glycol and polycaprolactone and its potential for siRNA delivery[J]. Chinese Chemical Letters, 2011, 22(6): 749-752. doi: 10.1016/j.cclet.2010.12.057
Synthesis of polyethylenimine grafted with copolymers of polyethylene glycol and polycaprolactone and its potential for siRNA delivery
摘要:
Copolymers mPEG-PCL were prepared and grafted onto polyethylenimine(PEI)to synthesize copolymers mPEG-PCL-g-PEI with low cytotoxicity.The mPEG-PCL-g-PEI could condense siRNA to form nanoparticles with positive zeta potential.These nanoparticles could delivery siRNA into cells to effectively inhibit the expression of target gene, which suggested that mPEG-PCL-g-PEl could serve as a highly efficient vector for siRNA delivery.
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关键词:
- Copolymers
- / Nanoparticles
- / Vector
- / Synthesis
English
Synthesis of polyethylenimine grafted with copolymers of polyethylene glycol and polycaprolactone and its potential for siRNA delivery
Abstract:
Copolymers mPEG-PCL were prepared and grafted onto polyethylenimine(PEI)to synthesize copolymers mPEG-PCL-g-PEI with low cytotoxicity.The mPEG-PCL-g-PEI could condense siRNA to form nanoparticles with positive zeta potential.These nanoparticles could delivery siRNA into cells to effectively inhibit the expression of target gene, which suggested that mPEG-PCL-g-PEl could serve as a highly efficient vector for siRNA delivery.
-
Key words:
- Copolymers
- / Nanoparticles
- / Vector
- / Synthesis
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