引用本文:
Jie Sun, c, Wei Xian Ding, Ke Yun Zhang, Yong Zou. Efficient synthesis and biological evaluation of 4-arylcoumarin derivatives[J]. Chinese Chemical Letters,
2011, 22(6): 677-670.
doi:
10.1016/j.cclet.2010.12.017
Citation: Jie Sun, c, Wei Xian Ding, Ke Yun Zhang, Yong Zou. Efficient synthesis and biological evaluation of 4-arylcoumarin derivatives[J]. Chinese Chemical Letters, 2011, 22(6): 677-670. doi: 10.1016/j.cclet.2010.12.017
Citation: Jie Sun, c, Wei Xian Ding, Ke Yun Zhang, Yong Zou. Efficient synthesis and biological evaluation of 4-arylcoumarin derivatives[J]. Chinese Chemical Letters, 2011, 22(6): 677-670. doi: 10.1016/j.cclet.2010.12.017
Efficient synthesis and biological evaluation of 4-arylcoumarin derivatives
摘要:
Two bioactive natural 4-arylcoumarins, 5,7,4'-trimethoxy-4-phenylcoumarin(1a), 5,7-dimethoxy-4-phenylcoumarin(1b)and five closely related derivatives 1c-g were synthesized.In vitro evaluation with a catechol subunit for antioxidant and antimicrobial activity, these compounds using standard methods showed that compounds 1d, 1f displayed promise radical scavenging activity and 1f was found to be the most active one against Bacillus dysenteriae.
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关键词:
- 4-Arylcoumarin
- / Synthesis
- / Antimicrobial
- / Antioxidant
English
Efficient synthesis and biological evaluation of 4-arylcoumarin derivatives
Abstract:
Two bioactive natural 4-arylcoumarins, 5,7,4'-trimethoxy-4-phenylcoumarin(1a), 5,7-dimethoxy-4-phenylcoumarin(1b)and five closely related derivatives 1c-g were synthesized.In vitro evaluation with a catechol subunit for antioxidant and antimicrobial activity, these compounds using standard methods showed that compounds 1d, 1f displayed promise radical scavenging activity and 1f was found to be the most active one against Bacillus dysenteriae.
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Key words:
- 4-Arylcoumarin
- / Synthesis
- / Antimicrobial
- / Antioxidant
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