引用本文:
Dong Chen, Xin Zhai, Qiu Hui Yuan, Jian Luo, Si Chang Xie, Ping Gong. Synthesis and in vitro anti-hepatitis B virus activity of 1H-benzimidazol-5-ol derivatives[J]. Chinese Chemical Letters,
2010, 21(11): 1326-1326.
doi:
10.1016/j.cclet.2010.05.011
Citation: Dong Chen, Xin Zhai, Qiu Hui Yuan, Jian Luo, Si Chang Xie, Ping Gong. Synthesis and in vitro anti-hepatitis B virus activity of 1H-benzimidazol-5-ol derivatives[J]. Chinese Chemical Letters, 2010, 21(11): 1326-1326. doi: 10.1016/j.cclet.2010.05.011
Citation: Dong Chen, Xin Zhai, Qiu Hui Yuan, Jian Luo, Si Chang Xie, Ping Gong. Synthesis and in vitro anti-hepatitis B virus activity of 1H-benzimidazol-5-ol derivatives[J]. Chinese Chemical Letters, 2010, 21(11): 1326-1326. doi: 10.1016/j.cclet.2010.05.011
Synthesis and in vitro anti-hepatitis B virus activity of 1H-benzimidazol-5-ol derivatives
摘要:
A series of 1H-benzimidazol-5-ol derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activity and eytotoxicity in HepG2.2.15 cells. Half of the tested compounds were found to be potent against HBsAg secretion with IC50 values less than 100 μmol/L. Compounds 14c, 14d, and 14e showed significant inhibitory activity to the viral antigen HBeAg.
English
Synthesis and in vitro anti-hepatitis B virus activity of 1H-benzimidazol-5-ol derivatives
Abstract:
A series of 1H-benzimidazol-5-ol derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activity and eytotoxicity in HepG2.2.15 cells. Half of the tested compounds were found to be potent against HBsAg secretion with IC50 values less than 100 μmol/L. Compounds 14c, 14d, and 14e showed significant inhibitory activity to the viral antigen HBeAg.
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Key words:
- 1H-benzimidazol-5-ol
- / Synthesis
- / Anti-HBV activity
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