引用本文:
Ya Jun Yang, Ya Nan Yang, Jian Shuang Jiang, Zi Ming Feng, Hong Yan Liu, Xian Dao Pan, Pei Cheng Zhang. Synthesis and cytotoxic activity of heterocycle-substituted phthalimide derivatives[J]. Chinese Chemical Letters,
2010, 21(8): 902-904.
doi:
10.1016/j.cclet.2010.03.039
Citation: Ya Jun Yang, Ya Nan Yang, Jian Shuang Jiang, Zi Ming Feng, Hong Yan Liu, Xian Dao Pan, Pei Cheng Zhang. Synthesis and cytotoxic activity of heterocycle-substituted phthalimide derivatives[J]. Chinese Chemical Letters, 2010, 21(8): 902-904. doi: 10.1016/j.cclet.2010.03.039
Citation: Ya Jun Yang, Ya Nan Yang, Jian Shuang Jiang, Zi Ming Feng, Hong Yan Liu, Xian Dao Pan, Pei Cheng Zhang. Synthesis and cytotoxic activity of heterocycle-substituted phthalimide derivatives[J]. Chinese Chemical Letters, 2010, 21(8): 902-904. doi: 10.1016/j.cclet.2010.03.039
Synthesis and cytotoxic activity of heterocycle-substituted phthalimide derivatives
摘要:
A series of heterocycle-substituted phthalimide derivatives were synthesized. Structurally diverse derivatives with heterocyclic rings, including furan, imidazo [1,2-a] pyridine, 1,3,4-thiadiazine, imidazo [2,1-b] [l,3,4]thiadiazine, pyrazole, 1,2,4-triazolo [3,4-b] [1,3,4]thiadiazine, thiazole and thiazoline, were obtained by the reactions of α-bromoketone intermediate with various nucleophiles containing oxygen, nitrogen and sulfur atom. Their cytotoxic activity was also evaluated against five human cancer cell lines in vitro.
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关键词:
- Phthalimide
- / Heterocycle
- / α-Bromoketone
- / Cytotoxic activity
English
Synthesis and cytotoxic activity of heterocycle-substituted phthalimide derivatives
Abstract:
A series of heterocycle-substituted phthalimide derivatives were synthesized. Structurally diverse derivatives with heterocyclic rings, including furan, imidazo [1,2-a] pyridine, 1,3,4-thiadiazine, imidazo [2,1-b] [l,3,4]thiadiazine, pyrazole, 1,2,4-triazolo [3,4-b] [1,3,4]thiadiazine, thiazole and thiazoline, were obtained by the reactions of α-bromoketone intermediate with various nucleophiles containing oxygen, nitrogen and sulfur atom. Their cytotoxic activity was also evaluated against five human cancer cell lines in vitro.
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Key words:
- Phthalimide
- / Heterocycle
- / α-Bromoketone
- / Cytotoxic activity
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