引用本文:
Li Tian, Jie Song, Jing Wang, Bin Liu. Synthesis and bioactivity of N-cyclopropanecarboxyl-N'-pyridin-2-yl thiourea derivatives and related fused ring compounds[J]. Chinese Chemical Letters,
2009, 20(3): 288-291.
doi:
10.1016/j.cclet.2008.11.027
Citation: Li Tian, Jie Song, Jing Wang, Bin Liu. Synthesis and bioactivity of N-cyclopropanecarboxyl-N'-pyridin-2-yl thiourea derivatives and related fused ring compounds[J]. Chinese Chemical Letters, 2009, 20(3): 288-291. doi: 10.1016/j.cclet.2008.11.027
Citation: Li Tian, Jie Song, Jing Wang, Bin Liu. Synthesis and bioactivity of N-cyclopropanecarboxyl-N'-pyridin-2-yl thiourea derivatives and related fused ring compounds[J]. Chinese Chemical Letters, 2009, 20(3): 288-291. doi: 10.1016/j.cclet.2008.11.027
Synthesis and bioactivity of N-cyclopropanecarboxyl-N'-pyridin-2-yl thiourea derivatives and related fused ring compounds
摘要:
Cyclopropanecarboxylic acid or 2,2-dimethyl cyclopropanecarboxylic acid was used as a leading compound for its biological activity. Six new N-(substituted) cyclopropanecarboxyl-N'-pyridin-2-yl thioureas were prepared. Compound 5 was obtained by oxidizing cyclization of compound 4 in the presence of bromine in chloroform solution. The structures of 4 and 5 were confirmed by 1H NMR and elemental analysis. The preliminary biological tests indicate that compound 4b and 4e have excellent herbicidal activity, and compound 4c and 4f have excellent fungicidal activity.
English
Synthesis and bioactivity of N-cyclopropanecarboxyl-N'-pyridin-2-yl thiourea derivatives and related fused ring compounds
Abstract:
Cyclopropanecarboxylic acid or 2,2-dimethyl cyclopropanecarboxylic acid was used as a leading compound for its biological activity. Six new N-(substituted) cyclopropanecarboxyl-N'-pyridin-2-yl thioureas were prepared. Compound 5 was obtained by oxidizing cyclization of compound 4 in the presence of bromine in chloroform solution. The structures of 4 and 5 were confirmed by 1H NMR and elemental analysis. The preliminary biological tests indicate that compound 4b and 4e have excellent herbicidal activity, and compound 4c and 4f have excellent fungicidal activity.
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Key words:
- Cyclopropanecarboxylic acid
- / Heterocycle
- / Thiourea
- / Biological activity
- / Pyridine
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