Synthesis and preliminary biological evaluation of the derivatives of O⁶-benzylguanine as inactivators of O⁶-alkylguanine-DNA alkyltransferase

• Lei Zhang ^a,c, ,
• Bing Jia ^b, ,
• Chang Feng Hu ^a, ,
• Fan Wang ^b, ,
• Yu Xin Cui ^a,c,

• a The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Science, Peking University, Beijing 100083, PR China;

• b Medical Isotope Research Center, Peking University, Beijing 100083, PR China;

• c Medical and Healthy Analysis Center, Peking University, Beijing 100083, PR China

• Received Date: 25 February 2008
  
• Fund Project:

  This research was supported by research Grant from Beijing Science and Technology Program (No.00004105040311).