引用本文:
Na Zhang, Mei Li Guo, Ge Zhang, Run Ping Li. A new neuroprotective bakkenolide from the rhizome of Petasites tricholobus[J]. Chinese Chemical Letters,
2008, 19(7): 841-844.
doi:
10.1016/j.cclet.2008.04.036
Citation: Na Zhang, Mei Li Guo, Ge Zhang, Run Ping Li. A new neuroprotective bakkenolide from the rhizome of Petasites tricholobus[J]. Chinese Chemical Letters, 2008, 19(7): 841-844. doi: 10.1016/j.cclet.2008.04.036
Citation: Na Zhang, Mei Li Guo, Ge Zhang, Run Ping Li. A new neuroprotective bakkenolide from the rhizome of Petasites tricholobus[J]. Chinese Chemical Letters, 2008, 19(7): 841-844. doi: 10.1016/j.cclet.2008.04.036
A new neuroprotective bakkenolide from the rhizome of Petasites tricholobus
摘要:
A new bakkenolide-type compound, bakkenolide-Va(1), was isolated from the rhizome of Petasites tricholobus. The structure was characterized on the basis of various NMR (1H, 13C, 1H-1H COSY, HMQC, HMBC and NOESY) and mass spectrometry data. The neuroprotective activity of bakkenolide-Va was investigated in primarily cultured neurons treated by hypoxia-glucose deprivation and various types of oxidative insults.
English
A new neuroprotective bakkenolide from the rhizome of Petasites tricholobus
Abstract:
A new bakkenolide-type compound, bakkenolide-Va(1), was isolated from the rhizome of Petasites tricholobus. The structure was characterized on the basis of various NMR (1H, 13C, 1H-1H COSY, HMQC, HMBC and NOESY) and mass spectrometry data. The neuroprotective activity of bakkenolide-Va was investigated in primarily cultured neurons treated by hypoxia-glucose deprivation and various types of oxidative insults.
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Key words:
- Petasites tricholobus
- / Compositae
- / Bakkenolide-Va
- / Neuroprotection
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