引用本文:
Chen Xi Zhang, Guo Jun Zheng, Fu Qiang Bi, Yu Lin Li. A simple and efficient synthesis of the valsartan[J]. Chinese Chemical Letters,
2008, 19(7): 759-761.
doi:
10.1016/j.cclet.2008.04.032
Citation: Chen Xi Zhang, Guo Jun Zheng, Fu Qiang Bi, Yu Lin Li. A simple and efficient synthesis of the valsartan[J]. Chinese Chemical Letters, 2008, 19(7): 759-761. doi: 10.1016/j.cclet.2008.04.032
Citation: Chen Xi Zhang, Guo Jun Zheng, Fu Qiang Bi, Yu Lin Li. A simple and efficient synthesis of the valsartan[J]. Chinese Chemical Letters, 2008, 19(7): 759-761. doi: 10.1016/j.cclet.2008.04.032
A simple and efficient synthesis of the valsartan
摘要:
Valsartan 1,one of the most important agents used in antihypertensive therapy today,was synthesized starting from L-valin methyl ester hydrochloride 2 through four steps in an overall yield of 60%.The key step involves the palladium-catalyzed SuzuKi coupling.This method overcomes many of the drawbacks associated with the previously reported syntheses and is more suitable for industrial production.
English
A simple and efficient synthesis of the valsartan
Abstract:
Valsartan 1,one of the most important agents used in antihypertensive therapy today,was synthesized starting from L-valin methyl ester hydrochloride 2 through four steps in an overall yield of 60%.The key step involves the palladium-catalyzed SuzuKi coupling.This method overcomes many of the drawbacks associated with the previously reported syntheses and is more suitable for industrial production.
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Key words:
- Valsartan
- / Antihypertensive
- / L-Valin methyl ester hydrochloride
- / Synthesis
- / Suzuki coupling
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