引用本文:
Guo Wei Yin, Yi Ming Li, Wei Wei, Shan Hao Jiang, Da Yuan Zhu, Wei Hong Du. Interactions of acetylcholinesterase with salvianolic acid B and rosmarinic acid from Salvia miltiorhiza water extract investigated by NMR relaxation rate[J]. Chinese Chemical Letters,
2008, 19(6): 747-751.
doi:
10.1016/j.cclet.2008.04.013
Citation: Guo Wei Yin, Yi Ming Li, Wei Wei, Shan Hao Jiang, Da Yuan Zhu, Wei Hong Du. Interactions of acetylcholinesterase with salvianolic acid B and rosmarinic acid from Salvia miltiorhiza water extract investigated by NMR relaxation rate[J]. Chinese Chemical Letters, 2008, 19(6): 747-751. doi: 10.1016/j.cclet.2008.04.013
Citation: Guo Wei Yin, Yi Ming Li, Wei Wei, Shan Hao Jiang, Da Yuan Zhu, Wei Hong Du. Interactions of acetylcholinesterase with salvianolic acid B and rosmarinic acid from Salvia miltiorhiza water extract investigated by NMR relaxation rate[J]. Chinese Chemical Letters, 2008, 19(6): 747-751. doi: 10.1016/j.cclet.2008.04.013
Interactions of acetylcholinesterase with salvianolic acid B and rosmarinic acid from Salvia miltiorhiza water extract investigated by NMR relaxation rate
摘要:
In order to understand whether the ameliorating effect on old ages memory disorder by the root of Salvia miltiorhiza is related to the acetylcholinesterase (AChE) inhibition, two main ingredients, salvianolic acid B (1) and rosmarinic acid (2), which were isolated from S. miltiorhiza water extract, were investigated in vitro byNMR relaxation rate in this work. The results showed that the proton selective relaxation rates and the molecular rotational correlation time of proton pairs for compounds 1 and 2 increased significantly by adding of AChE in mixing solution. The study reveals that the two compounds might bind to the enzyme and have AChE inhibitory effect, which could contribute to the ameliorating effect at some extent on old ages memory disorder.
English
Interactions of acetylcholinesterase with salvianolic acid B and rosmarinic acid from Salvia miltiorhiza water extract investigated by NMR relaxation rate
Abstract:
In order to understand whether the ameliorating effect on old ages memory disorder by the root of Salvia miltiorhiza is related to the acetylcholinesterase (AChE) inhibition, two main ingredients, salvianolic acid B (1) and rosmarinic acid (2), which were isolated from S. miltiorhiza water extract, were investigated in vitro byNMR relaxation rate in this work. The results showed that the proton selective relaxation rates and the molecular rotational correlation time of proton pairs for compounds 1 and 2 increased significantly by adding of AChE in mixing solution. The study reveals that the two compounds might bind to the enzyme and have AChE inhibitory effect, which could contribute to the ameliorating effect at some extent on old ages memory disorder.
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Key words:
- AChE inhibitors
- / Salvianolic acid B
- / Rosmarinic acid
- / NMR relaxation rate
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