引用本文:
Shahnaz Rostamizadeh, Somaye Ghamkhar. A mild and facile method for one pot synthesis of 2,5-di-substituted 1,3,4-oxadiazoles at room temperature[J]. Chinese Chemical Letters,
2008, 19(6): 639-642.
doi:
10.1016/j.cclet.2008.03.027
Citation: Shahnaz Rostamizadeh, Somaye Ghamkhar. A mild and facile method for one pot synthesis of 2,5-di-substituted 1,3,4-oxadiazoles at room temperature[J]. Chinese Chemical Letters, 2008, 19(6): 639-642. doi: 10.1016/j.cclet.2008.03.027
Citation: Shahnaz Rostamizadeh, Somaye Ghamkhar. A mild and facile method for one pot synthesis of 2,5-di-substituted 1,3,4-oxadiazoles at room temperature[J]. Chinese Chemical Letters, 2008, 19(6): 639-642. doi: 10.1016/j.cclet.2008.03.027
A mild and facile method for one pot synthesis of 2,5-di-substituted 1,3,4-oxadiazoles at room temperature
摘要:
2,5-Di-substituted 1,3,4-oxadiazoles 3a-n have been synthesized as a one pot procedure from the reaction of acid hydrazide 1, acyl halides 2 and phosphorus pentoxide in acetonitrile at room temperature. High yield, short reaction time (10-15 min), mild condition, and easy work-up are advantages of this methodology.
English
A mild and facile method for one pot synthesis of 2,5-di-substituted 1,3,4-oxadiazoles at room temperature
Abstract:
2,5-Di-substituted 1,3,4-oxadiazoles 3a-n have been synthesized as a one pot procedure from the reaction of acid hydrazide 1, acyl halides 2 and phosphorus pentoxide in acetonitrile at room temperature. High yield, short reaction time (10-15 min), mild condition, and easy work-up are advantages of this methodology.
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Key words:
- 1,3,4-Oxadiazole
- / Acid hydrazide
- / Acyl halide
- / Phosphorus pentoxide
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