引用本文:
Yong Fu Huang, Li Qiao, A.Li Lv, Yue Hu Pei, Li Tian. Eremophilane sesquiterenes from the marine fungus Penicillium sp. BL27-2[J]. Chinese Chemical Letters,
2008, 19(5): 562-564.
doi:
10.1016/j.cclet.2008.03.018
Citation: Yong Fu Huang, Li Qiao, A.Li Lv, Yue Hu Pei, Li Tian. Eremophilane sesquiterenes from the marine fungus Penicillium sp. BL27-2[J]. Chinese Chemical Letters, 2008, 19(5): 562-564. doi: 10.1016/j.cclet.2008.03.018
Citation: Yong Fu Huang, Li Qiao, A.Li Lv, Yue Hu Pei, Li Tian. Eremophilane sesquiterenes from the marine fungus Penicillium sp. BL27-2[J]. Chinese Chemical Letters, 2008, 19(5): 562-564. doi: 10.1016/j.cclet.2008.03.018
Eremophilane sesquiterenes from the marine fungus Penicillium sp. BL27-2
摘要:
Six eremophilane sesquiterpenes were obtained from a marine fungus Penicillium sp. BL27-2. Their structures were elucidatedas 3-acetyl-9, 7 (11)-dien-7ot-hydroxy-8-oxoeremophilane (1), 3-acetyl-13-deoxyphomenone (2), Sporogen-AO 1 (3), 7-hydro-xypetasol (4), 8α-hydroxy-13-deo-xyphomenone (5) and 6-dehydropetasol (6) based on detailed NMR analysis. 1 was a newcompound and 2 was obtained as a new natural compound. These compounds were assayed for their cytotoxic activity on P388,A549, HL60, BEL7402 and K562 cell lines by the MTT method. The assay results suggested the epoxide tings in eremophilanemolecules were essential for their activity, and acetylation could enhance their activity.
English
Eremophilane sesquiterenes from the marine fungus Penicillium sp. BL27-2
Abstract:
Six eremophilane sesquiterpenes were obtained from a marine fungus Penicillium sp. BL27-2. Their structures were elucidatedas 3-acetyl-9, 7 (11)-dien-7ot-hydroxy-8-oxoeremophilane (1), 3-acetyl-13-deoxyphomenone (2), Sporogen-AO 1 (3), 7-hydro-xypetasol (4), 8α-hydroxy-13-deo-xyphomenone (5) and 6-dehydropetasol (6) based on detailed NMR analysis. 1 was a newcompound and 2 was obtained as a new natural compound. These compounds were assayed for their cytotoxic activity on P388,A549, HL60, BEL7402 and K562 cell lines by the MTT method. The assay results suggested the epoxide tings in eremophilanemolecules were essential for their activity, and acetylation could enhance their activity.
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Key words:
- Marine fungus
- / Eremophilane sesquiterpenes
- / NMR analysis
- / Cytotoxic activity
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