引用本文:
Li Qiao, Yu Zhi Zhou, Huan Chen, Jia Qing Cao, Yue Hu Pei. One new bufadienolide biotransformed from cinobufagin by Cunninghamella elegans[J]. Chinese Chemical Letters,
2008, 19(3): 299-301.
doi:
10.1016/j.cclet.2007.12.019
Citation: Li Qiao, Yu Zhi Zhou, Huan Chen, Jia Qing Cao, Yue Hu Pei. One new bufadienolide biotransformed from cinobufagin by Cunninghamella elegans[J]. Chinese Chemical Letters, 2008, 19(3): 299-301. doi: 10.1016/j.cclet.2007.12.019
Citation: Li Qiao, Yu Zhi Zhou, Huan Chen, Jia Qing Cao, Yue Hu Pei. One new bufadienolide biotransformed from cinobufagin by Cunninghamella elegans[J]. Chinese Chemical Letters, 2008, 19(3): 299-301. doi: 10.1016/j.cclet.2007.12.019
One new bufadienolide biotransformed from cinobufagin by Cunninghamella elegans
摘要:
Cunninghamella elegans has been employed for the biotransformation of cinobufagin (1) to afford one metabolites. The structure of the transformation product has been characterized as 7β, 12β-dihydroxylcinobufagin (2). Product 2 is a new compound. In vitro cytotoxic activities of the biotransformation product and the substrate-cinobufagin have been assayed against HeLa; they all showed cytotoxic activities.
English
One new bufadienolide biotransformed from cinobufagin by Cunninghamella elegans
Abstract:
Cunninghamella elegans has been employed for the biotransformation of cinobufagin (1) to afford one metabolites. The structure of the transformation product has been characterized as 7β, 12β-dihydroxylcinobufagin (2). Product 2 is a new compound. In vitro cytotoxic activities of the biotransformation product and the substrate-cinobufagin have been assayed against HeLa; they all showed cytotoxic activities.
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Key words:
- Biotransformation
- / Cinobufagin
- / 7β,12β-Dihydroxylcinobufagin
- / Cunninghamella elegans
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