引用本文:
Shan Zhen He, Xue Ming Li, Jia Dai, Ming Yan. Synthesis of antidepressant duloxetine via asymmetric transfer hydrogenation[J]. Chinese Chemical Letters,
2008, 19(1): 23-25.
doi:
10.1016/j.cclet.2007.10.046
Citation: Shan Zhen He, Xue Ming Li, Jia Dai, Ming Yan. Synthesis of antidepressant duloxetine via asymmetric transfer hydrogenation[J]. Chinese Chemical Letters, 2008, 19(1): 23-25. doi: 10.1016/j.cclet.2007.10.046
Citation: Shan Zhen He, Xue Ming Li, Jia Dai, Ming Yan. Synthesis of antidepressant duloxetine via asymmetric transfer hydrogenation[J]. Chinese Chemical Letters, 2008, 19(1): 23-25. doi: 10.1016/j.cclet.2007.10.046
Synthesis of antidepressant duloxetine via asymmetric transfer hydrogenation
摘要:
Antidepressant duloxetine (1) was prepared via asymmetric transfer hydrogenation of 3-(dimethylamino)-1-(thiophen-2-yl)propan-1-one (3). The Ru(Ⅱ), Rh(Ⅲ) and Ir(Ⅲ) complexes of several chiral ligands were examined as the catalyst and (S,S)-N-tosyl-1,2-diphenyl ethylenediamine (TsDPEN)-Ru(Ⅱ) complex was found to provide good yield and excellent enantios-electivity.
English
Synthesis of antidepressant duloxetine via asymmetric transfer hydrogenation
Abstract:
Antidepressant duloxetine (1) was prepared via asymmetric transfer hydrogenation of 3-(dimethylamino)-1-(thiophen-2-yl)propan-1-one (3). The Ru(Ⅱ), Rh(Ⅲ) and Ir(Ⅲ) complexes of several chiral ligands were examined as the catalyst and (S,S)-N-tosyl-1,2-diphenyl ethylenediamine (TsDPEN)-Ru(Ⅱ) complex was found to provide good yield and excellent enantios-electivity.
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Key words:
- Duloxetine
- / Synthesis
- / Asymmetric transfer hydrogenation
- / TsDPEN-Ru(Ⅱ) complex
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