引用本文:
Lei Xie, Ding Qiao Yang, Shuang Qi Zhao, Huan Wang, Li Hua Liang, Ren Shi Luo. Rhodium-catalyzed asymmetric ring opening of azabenzonorbornadiene with substituted piperazine nucleophiles[J]. Chinese Chemical Letters,
2007, 18(2): 127-129.
doi:
10.1016/j.cclet.2006.12.003
Citation: Lei Xie, Ding Qiao Yang, Shuang Qi Zhao, Huan Wang, Li Hua Liang, Ren Shi Luo. Rhodium-catalyzed asymmetric ring opening of azabenzonorbornadiene with substituted piperazine nucleophiles[J]. Chinese Chemical Letters, 2007, 18(2): 127-129. doi: 10.1016/j.cclet.2006.12.003
Citation: Lei Xie, Ding Qiao Yang, Shuang Qi Zhao, Huan Wang, Li Hua Liang, Ren Shi Luo. Rhodium-catalyzed asymmetric ring opening of azabenzonorbornadiene with substituted piperazine nucleophiles[J]. Chinese Chemical Letters, 2007, 18(2): 127-129. doi: 10.1016/j.cclet.2006.12.003
Rhodium-catalyzed asymmetric ring opening of azabenzonorbornadiene with substituted piperazine nucleophiles
摘要:
We have developed an asymmetric ring opening reaction of azabenzonorbornadiene with substituted piperazine. By increasing the amount of catalyst (from 2.5 to 5%) and ligands (5 to 10%) as well as addition of ammonium iodide, the products can be obtained in high yield and the reaction time shortened dramatically, but the ee values were rather low.
English
Rhodium-catalyzed asymmetric ring opening of azabenzonorbornadiene with substituted piperazine nucleophiles
Abstract:
We have developed an asymmetric ring opening reaction of azabenzonorbornadiene with substituted piperazine. By increasing the amount of catalyst (from 2.5 to 5%) and ligands (5 to 10%) as well as addition of ammonium iodide, the products can be obtained in high yield and the reaction time shortened dramatically, but the ee values were rather low.
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Key words:
- Rhodium-catalyzed
- / Asymmetric ring opening
- / Azabenzonorbornadiene
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