Effects of PEG Molecular Weight on Its Interaction with Albumin

Jing-jing Lai Huai-yu Yan Yan Liu Yanbin Huang

Citation:  Jing-jing Lai, Huai-yu Yan, Yan Liu, Yanbin Huang. Effects of PEG Molecular Weight on Its Interaction with Albumin[J]. Chinese Journal of Polymer Science, 2015, 33(10): 1373-1379. doi: 10.1007/s10118-015-1687-y shu

Effects of PEG Molecular Weight on Its Interaction with Albumin

    通讯作者: Yanbin Huang,
  • 基金项目:

    This work was financially supported by the National Natural Science Foundation of China (No. 21434008).

摘要: The fluorescence property of bovine serum albumin was investigated in the presence of PEGs of different molecular weights. Based on our results, we propose that PEGs of different molecular weights bind to albumin in the pH 7.4 aqueous solution, but only when the polymer size is larger than the protein size, one polymer chain may bind to multiple proteins and cause the proteins to aggregate.

English


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  • 发布日期:  2015-10-05
  • 收稿日期:  2015-03-16
  • 修回日期:  2015-04-07
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