A Method to Accelerate the Gelation of Disulfide-crosslinked Hydrogels

Xiaoshan Yan Xiaotong Yang Xinming Tong Yanbin Huang

Citation:  Xiaoshan Yan, Xiaotong Yang, Xinming Tong, Yanbin Huang. A Method to Accelerate the Gelation of Disulfide-crosslinked Hydrogels[J]. Chinese Journal of Polymer Science, 2015, 33(1): 118-127. doi: 10.1007/s10118-015-1567-5 shu

A Method to Accelerate the Gelation of Disulfide-crosslinked Hydrogels

  • 基金项目:

    This work was financially supported by the National Natural Science Foundation of China (No. 21004038).

摘要: A glutathione-disulfide-ended poly(ethylene glycol) (GSSG-PEG-GSSG) was designed. It is a much more efficient accelerator than glutathione disulfide (GSSG) for the gelation of an 8arm-PEG-SH polymer solution, and the gelation time can be tuned from hours to minutes at the physiological pH and temperature. A mechanism was proposed to explain the different behaviors of the GSSG and GSSG-PEG-GSSG gelation systems. Due to the ever-going thiol-disulfide exchange reaction, the thiol-disulfide hydrogels also showed interesting swelling behavior.

English

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  • 发布日期:  2015-01-05
  • 收稿日期:  2014-04-25
  • 修回日期:  2014-05-31
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