引用本文:
Ji Cheng CHU, Hong Sheng GUO, Jun Biao CHANG, Kang ZHAO. Synthesis of Novel Nucleoside Analog (3R)-2,3-Dideoxy-3-(N-hydroxy-N-methylamino)-L-arabinofuranosyl Uracil[J]. Chinese Chemical Letters,
2004, 15(7): 785-786.
Citation: Ji Cheng CHU, Hong Sheng GUO, Jun Biao CHANG, Kang ZHAO. Synthesis of Novel Nucleoside Analog (3R)-2,3-Dideoxy-3-(N-hydroxy-N-methylamino)-L-arabinofuranosyl Uracil[J]. Chinese Chemical Letters, 2004, 15(7): 785-786.
Citation: Ji Cheng CHU, Hong Sheng GUO, Jun Biao CHANG, Kang ZHAO. Synthesis of Novel Nucleoside Analog (3R)-2,3-Dideoxy-3-(N-hydroxy-N-methylamino)-L-arabinofuranosyl Uracil[J]. Chinese Chemical Letters, 2004, 15(7): 785-786.
Synthesis of Novel Nucleoside Analog (3R)-2,3-Dideoxy-3-(N-hydroxy-N-methylamino)-L-arabinofuranosyl Uracil
摘要:
The synthesis of novel nucleoside analog (3R)-2,3-dideoxy-3-(N-hydroxy-N-methylamino)-L-arabinofuranosyl uracil was studied. A twelve-step synthetic route, started from L-ascorbic acid, was designed, and the final product was obtained in 20.8% yield.
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关键词:
- L-Nucleoside
- / Wittig reaction
- / Michael addition
- / uracil analog
English
Synthesis of Novel Nucleoside Analog (3R)-2,3-Dideoxy-3-(N-hydroxy-N-methylamino)-L-arabinofuranosyl Uracil
Abstract:
The synthesis of novel nucleoside analog (3R)-2,3-dideoxy-3-(N-hydroxy-N-methylamino)-L-arabinofuranosyl uracil was studied. A twelve-step synthetic route, started from L-ascorbic acid, was designed, and the final product was obtained in 20.8% yield.
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Key words:
- L-Nucleoside
- / Wittig reaction
- / Michael addition
- / uracil analog
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